Abstract: Embodiments of the present disclosure provide materials and methods relating to cell and tissue culture testing systems. Certain embodiments of the present disclosure relate to in vitro testing systems that are useful for performing experiments to investigate the potential for various factors to reduce bioburden, reduce the manifestations of infection, and to promote wound healing in cultured cells and tissues. In some embodiments, the present disclosure provides means for investigating biological mechanisms underlying wound healing, including the ability of pressurized gas to reduce the manifestations of infection by reducing bioburden.

Abstract: A system and method of generating screensavers. In one embodiment, a client may upload a plurality of images to a screensaver server. The server creates a screensaver application program using the uploaded images. In one embodiment, the screensaver application program compresses the uploaded images. The screensaver transmits the generated screensaver program to the user for installation on the user's computer.

Abstract: The present invention relates to improved diagnostic agents for Magnetic Resonance Imaging and optical imaging. In particular, this invention relates to MRI and optical imaging agents that allow for the sensitive detection of a specific bioactivity within a tissue. These agents are prodrug contrast agents which are bioactivated in vivo in the presence of the specific bioactivity. This invention also relates to pharmaceutical compositions comprising these agents and to methods of using the agents and compositions comprising the agents.

Abstract: The present invention relates to a contrast-enhanced diagnostic imaging method for monitoring the efficacy of interventional therapies. The contrast agents useful in this method comprise an image-enhancing moiety (IEM) and a state-dependent tissue binding moiety (SDTBM). These contrast agents exhibit state-dependent binding to one or more components of a targeted tissue or tissue component and provide a detectable change in the signal characteristics of the agent once bound to the targeted tissue. As a result, these agents exhibit a binding affinity for, and thus image contrast of, the targeted tissue which changes as the tissue-state changes during therapy.