Abstract: The present disclosure provides antagonist fusion polypeptides (e.g., with extended half-life, improved antagonist activity) comprising (i) a serum albumin binding polypeptide; (ii) a polypeptide hormone analog capable of antagonizing its receptor activation; and (iii) a linker, as well as various related technologies including, methods of producing and using such fusion polypeptides.

Abstract: Techniques are provided for feature toggle management with application behavior point-in-time restoration using event sourcing. One method comprises maintaining feature toggle events for features of an application, wherein each feature toggle event comprises an indication of an event time of the respective feature toggle event for a given feature; receiving a request to execute the application with feature toggle settings associated with an indicated point-in-time; and initiating an execution of the application with the feature toggle settings associated with the indicated point-in-time by processing the feature toggle events having an event time up to the indicated point-in-time. Event sourcing techniques may be employed to store the plurality of feature toggle events for the plurality of features in an event repository.

Abstract: Techniques are provided for feature toggle management with application behavior point-in-time restoration using event sourcing. One method comprises maintaining feature toggle events for features of an application, wherein each feature toggle event comprises an indication of an event time of the respective feature toggle event for a given feature; receiving a request to execute the application with feature toggle settings associated with an indicated point-in-time; and initiating an execution of the application with the feature toggle settings associated with the indicated point-in-time by processing the feature toggle events having an event time up to the indicated point-in-time. Event sourcing techniques may be employed to store the plurality of feature toggle events for the plurality of features in an event repository.

Abstract: This invention relates to oil lubricated helium compressor units for use in cryogenic refrigeration systems, operating on the Gifford McMahon (GM) or Brayton cycle. The objective of this invention is to provide redundancy by having a water cooled compressor manifolded to an air cooled compressor and sensors to detect faults so that an expander can be kept running if there is a failure in either the water or air supply.

Abstract: A system and method for reducing execution errors make by a software service are disclosed. The service has several features whose execution paths are switched on or off by corresponding feature toggles, i.e. flags in a configuration database. The performance, and especially error generation, of each feature is monitored automatically and an instantaneous error rate is produced. When the error rate exceeds a given threshold error rate for a particular feature, the corresponding toggle is disabled in the configuration database and the service is triggered to restart using the updated toggles, thereby disabling the problematic feature. The system and method also determine whether the error rate increased due to a transient error condition, such as a data link drop or a secondary service restart, and re-enable the toggle when the error condition has passed.

Abstract: This invention relates to oil lubricated helium compressor units for use in cryogenic refrigeration systems, operating on the Gifford McMahon (GM) or Brayton cycle. The objective of this invention is to provide redundancy by having a water cooled compressor manifolded to an air cooled compressor and sensors to detect faults so that an expander can be kept running if there is a failure in either the water or air supply.

Abstract: A system and method for reducing execution errors make by a software service are disclosed. The service has several features whose execution paths are switched on or off by corresponding feature toggles, i.e. flags in a configuration database. The performance, and especially error generation, of each feature is monitored automatically and an instantaneous error rate is produced. When the error rate exceeds a given threshold error rate for a particular feature, the corresponding toggle is disabled in the configuration database and the service is triggered to restart using the updated toggles, thereby disabling the problematic feature. The system and method also determine whether the error rate increased due to a transient error condition, such as a data link drop or a secondary service restart, and re-enable the toggle when the error condition has passed.

Abstract: A collapsible three-legged platform is provided. The three legs are attached at a central pivot point such that the platform can collapse. The legs can be adapted to support a variety of objects.

Abstract: An auto-injector assembly comprises a medicament container defining a substantially cylindrical chamber containing a liquid medicament. A proximal end of the chamber is closed by a piston and a distal end of the chamber is closed by a seal spanning an opening. A biasing means, such as a spring, is coupled to the piston and acts to bias the piston towards the seal, thereby pressurizing the liquid medicament. The assembly also comprises a hypodermic needle and a removable needle cap for maintaining the hypodermic needle in sterile conditions until use. A means for establishes fluid communication between the chamber and the hypodermic needle such that the pressurized liquid medicament is automatically delivered through the hypodermic needle when communication has been established.

Abstract: A collapsible three-legged platform is provided. The three legs are attached at a central pivot point such that the platform can collapse. The legs can be adapted to support a variety of objects.

Abstract: A collapsible three-legged platform is provided. The three legs are attached at a central pivot point such that the platform can collapse flat. The legs can be adapted to support a variety of objects.

Abstract: A collapsible three-legged platform is provided. The three legs are attached at a central pivot point such that the platform can collapse flat. The legs can be adapted to support a variety of objects.

Abstract: This invention relates to oil lubricated helium compressor units for use in cryogenic refrigeration systems, operating on the Gifford McMahon (GM) or Brayton cycle. The objective of this invention is to provide redundancy by having a water cooled compressor manifolded to an air cooled compressor and sensors to detect faults so that an expander can be kept running if there is a failure in either the water or air supply.

Abstract: An injector assembly comprises a collapsible container for containing a liquid medicament (15); and pressurising means (21, 101) arranged to apply a first force to the collapsible container to continuously pressurise the liquid medicament 15 during storage of the liquid medicament 15. The pressurising means (21, 101) is actuatable to apply a second force, which is greater than the first force, to the collapsible container.

Abstract: This invention provides a means to start an oil lubricated air cooled helium compressor at ambient air temperatures in the range from ?30° C. to 0° C. by heating the oil in the sump and opening one or more by-pass valves that allows oil to flow to the oil injection port of the compressor without passing through all of the after-cooler.

Abstract: An expansion engine operating on a Brayton cycle which is part of a system for producing refrigeration at cryogenic temperatures that includes a compressor, a counter-flow heat exchanger, and a load that may be remote, which is cooled by gas circulating from the engine. The engine has a piston in a cylinder which has nearly the same pressure above and below the piston while it is moving. Low pressure on a piston drive stem provides a force imbalance to move the piston towards the warm end.

Abstract: An auto-injector for delivering a liquid medicament comprises: a collapsible container for containing the liquid medicament (26); an openable closure; and an elongate indication member (21) located at least partially within the rigid outer container (22) and arranged to move longitudinally towards the distal end of the collapsible container when the openable closure is opened, in which longitudinal movement of the elongate indication member (21) produces visual, and/or audio and/or tactile feedback relating to injection progress to a user of the auto-injector.

Abstract: A needle safety shield assembly for an injector comprises: a needle shield (231) for shielding a needle of the injector; and a shield locking means comprising a track (233, 236) adapted to engage with a runner (224), the track comprising at least one unidirectional barrier (232, 237) through which the runner can pass; in which movement of the needle shield to expose the needle for use and to subsequently re-shield the needle causes movement of the runner (224) along the track (233, 236) through the at least one unidirectional barrier (232, 237) and into a locked position in which further movement of the runner and needle shield is prevented.

Abstract: A hand-held pre-filled syringe assembly comprises a syringe barrel, a piston slidably located within the syringe barrel, biasing means coupled to the piston and acting to bias the piston within the syringe barrel, a hypodermic needle, and an openable closure having an inlet and an outlet disposed between the syringe barrel and the hypodermic needle. The inlet of the openable closure is removably coupled to a nozzle of the syringe barrel by a first coupling and the outlet of the openable closure is coupled to a proximal end of the hypodermic needle by a second coupling. The openable closure defines a through-channel extending between the inlet and the outlet that is closed by a normally-closed valve. The syringe assembly contains a liquid medicament retained within the syringe barrel under pressure applied by the piston such that the liquid medicament is delivered through the hypodermic needle when the normally-closed valve is opened.