Abstract: The present invention relates to the field of medicine, specifically the field of bacterial infection and treatment thereof.

Abstract: Techniques are provided for feature toggle management with application behavior point-in-time restoration using event sourcing. One method comprises maintaining feature toggle events for features of an application, wherein each feature toggle event comprises an indication of an event time of the respective feature toggle event for a given feature; receiving a request to execute the application with feature toggle settings associated with an indicated point-in-time; and initiating an execution of the application with the feature toggle settings associated with the indicated point-in-time by processing the feature toggle events having an event time up to the indicated point-in-time. Event sourcing techniques may be employed to store the plurality of feature toggle events for the plurality of features in an event repository.

Abstract: The present invention is an auto-injector for the administration and self-administration of drugs by subcutaneous, intramuscular or intra-dermal injection and for drug solutions or suspensions. The auto-injector may comprise three modules for ease of assembly, the modules principally including a standard cartridge module with stopper and septum, a power source and indicator module that pushes against the cartridge stopper pressurizing contents, an injection progress indicator and a needle shuttle comprising of two needles, one needle being the injection needle and one needle being the septum needle. A needle guard ensures that the needle is always covered thus hiding the needle before and after the injection and that prevents needle stick injurie.

Abstract: Techniques are provided for feature toggle management with application behavior point-in-time restoration using event sourcing. One method comprises maintaining feature toggle events for features of an application, wherein each feature toggle event comprises an indication of an event time of the respective feature toggle event for a given feature; receiving a request to execute the application with feature toggle settings associated with an indicated point-in-time; and initiating an execution of the application with the feature toggle settings associated with the indicated point-in-time by processing the feature toggle events having an event time up to the indicated point-in-time. Event sourcing techniques may be employed to store the plurality of feature toggle events for the plurality of features in an event repository.

Abstract: A system and method for reducing execution errors make by a software service are disclosed. The service has several features whose execution paths are switched on or off by corresponding feature toggles, i.e. flags in a configuration database. The performance, and especially error generation, of each feature is monitored automatically and an instantaneous error rate is produced. When the error rate exceeds a given threshold error rate for a particular feature, the corresponding toggle is disabled in the configuration database and the service is triggered to restart using the updated toggles, thereby disabling the problematic feature. The system and method also determine whether the error rate increased due to a transient error condition, such as a data link drop or a secondary service restart, and re-enable the toggle when the error condition has passed.

Abstract: A system and method for reducing execution errors make by a software service are disclosed. The service has several features whose execution paths are switched on or off by corresponding feature toggles, i.e. flags in a configuration database. The performance, and especially error generation, of each feature is monitored automatically and an instantaneous error rate is produced. When the error rate exceeds a given threshold error rate for a particular feature, the corresponding toggle is disabled in the configuration database and the service is triggered to restart using the updated toggles, thereby disabling the problematic feature. The system and method also determine whether the error rate increased due to a transient error condition, such as a data link drop or a secondary service restart, and re-enable the toggle when the error condition has passed.

Abstract: An auto-injector assembly comprises a medicament container defining a substantially cylindrical chamber containing a liquid medicament. A proximal end of the chamber is closed by a piston and a distal end of the chamber is closed by a seal spanning an opening. A biasing means, such as a spring, is coupled to the piston and acts to bias the piston towards the seal, thereby pressurizing the liquid medicament. The assembly also comprises a hypodermic needle and a removable needle cap for maintaining the hypodermic needle in sterile conditions until use. A means for establishes fluid communication between the chamber and the hypodermic needle such that the pressurized liquid medicament is automatically delivered through the hypodermic needle when communication has been established.

Abstract: An injector assembly comprises a collapsible container for containing a liquid medicament (15); and pressurising means (21, 101) arranged to apply a first force to the collapsible container to continuously pressurise the liquid medicament 15 during storage of the liquid medicament 15. The pressurising means (21, 101) is actuatable to apply a second force, which is greater than the first force, to the collapsible container.

Abstract: A needle safety shield assembly for an injector comprises: a needle shield (231) for shielding a needle of the injector; and a shield locking means comprising a track (233, 236) adapted to engage with a runner (224), the track comprising at least one unidirectional barrier (232, 237) through which the runner can pass; in which movement of the needle shield to expose the needle for use and to subsequently re-shield the needle causes movement of the runner (224) along the track (233, 236) through the at least one unidirectional barrier (232, 237) and into a locked position in which further movement of the runner and needle shield is prevented.

Abstract: An auto-injector for delivering a liquid medicament comprises: a collapsible container for containing the liquid medicament (26); an openable closure; and an elongate indication member (21) located at least partially within the rigid outer container (22) and arranged to move longitudinally towards the distal end of the collapsible container when the openable closure is opened, in which longitudinal movement of the elongate indication member (21) produces visual, and/or audio and/or tactile feedback relating to injection progress to a user of the auto-injector.

Abstract: A hand-held pre-filled syringe assembly comprises a syringe barrel, a piston slidably located within the syringe barrel, biasing means coupled to the piston and acting to bias the piston within the syringe barrel, a hypodermic needle, and an openable closure having an inlet and an outlet disposed between the syringe barrel and the hypodermic needle. The inlet of the openable closure is removably coupled to a nozzle of the syringe barrel by a first coupling and the outlet of the openable closure is coupled to a proximal end of the hypodermic needle by a second coupling. The openable closure defines a through-channel extending between the inlet and the outlet that is closed by a normally-closed valve. The syringe assembly contains a liquid medicament retained within the syringe barrel under pressure applied by the piston such that the liquid medicament is delivered through the hypodermic needle when the normally-closed valve is opened.

Abstract: An auto-injector assembly comprises a medicament container defining a substantially cylindrical chamber containing a liquid medicament. A proximal end of the chamber is closed by a piston and a distal end of the chamber is closed by a seal spanning an opening. A biasing means, such as a spring, is coupled to the piston and acts to bias the piston towards the seal, thereby pressurising the liquid medicament. The assembly also comprises a hypodermic needle and a removable needle cap for maintaining the hypodermic needle in sterile conditions until use. A means for establishes fluid communication between the chamber and the hypodermic needle such that the pressurised liquid medicament is automatically delivered through the hypodermic needle when communication has been established.

Abstract: A dry powder inhaler (1) is to be made available, with which a particle size and particle size distribution preferred for inhalation are to be achieved and by means of which as high a line particle fraction as possible is to be realized. This is achieved by means of a dry powder inhaler (1 ) that is characterized in that provided in the inhaler (1) is a nozzle (10) through which the aerosol (9) flows before leaving the inhaler (1).

Abstract: The present invention relates to a propellant-gas-free apparatus for the dispensing of liquids, a container cartridge suitable for this for storing the liquid and the ensemble comprising both. The invention comprises a device for the exertion of pressure and for accommodating a container cartridge and a container cartridge in which the dispensing facility is integrated.

Abstract: The present invention relates to a propellant-gas-free apparatus for the dispensing of liquids, a container cartridge suitable for this for storing the liquid and the ensemble comprising both. The invention comprises a device for the exertion of pressure and for accommodating a container cartridge and a container cartridge in which the dispensing facility is integrated.

Abstract: The invention relates to a nozzle system for a delivery device for liquids, wherein the nozzle system comprises a nozzle and a device which fixes the nozzle in the delivery device. The delivery device, an atomizer, has a liquid reservoir from which a liquid is forced through the nozzle under pressure. The nozzle fixing means may itself be secured by a second fixing, e.g., in the form of a check nut, or the fixing may itself be a check nut. According to the invention the fixing means on the nozzle outlet side has a specific geometry which minimizes the proportion of dispensed liquid deposited on the fixing means. Preferably, the present invention is part of a propellant-free device for nebulizing pharmaceutical liquids.

Abstract: An electrophysiological sensor, weak electrical signal conditioning circuit and method for controlling the circuit as provided. The sensor includes rigid filiform conducting nanostructures connected to a conducting substrate and operable to penetrate an organic tissue. The circuit includes an instrumentation amplifier with an input connected to a first electrode in contact with a first area of a medium, and a second input; a voltage generating device connected to an electrode in contact with a second area of the medium for applying a continuous reference signal to it; a compensator, electrically insulated from the device, for compensating the direct current offsets of a weak electrical signal received by the first electrode, generating a signal with a reference voltage with a value which can be modified by a control system, and supplying it to the second input. A method is also provided for controlling the circuit.

Abstract: An atomizer, a reservoir and a method are proposed for the delivery and in particular, the atomization of a formulation, particularly a powder. A pump and a spring are arranged inside the annular reservoir, the pump and the spring being moveable radially and in a sliding manner. The pump is actuated by the spring to put air under pressure for discharging powder from the reservoir. The reservoir comprises receptacles or cavities, each of which has an insert with a respective dose of the formulation. The receptacles are constructed as separate parts and/or arranged on a common or annular carrier and/or are sealed separately and/or on its outer circumferential periphery. The spring is tensioned and the air is sucked into the pump. Then, the next receptacle and a connecting element are aligned relative to each other. Finally, the aligned receptacle is pierced by the connecting element for supplying the air.

Abstract: A dispensing device, a storage device and a method for dispensing powder in which powder is dispensed through a duct with a flat cross section to de-agglomerate the powder and to generate a spray with fine particle size. A storage chamber for the powder may be closed by a bursting element which is burst by pressurized gas for discharging the powder, the gas pressure reaching or exceeding a peak value before the bursting element bursts so that the powder is dispensed at a lower gas pressure. The powder may be forced through the duct by a gas pressure of less than 300 kPa to de-agglomerate the powder and/or to generate the spray. The storage device can have multiple storage chambers and associated ducts or nozzles, so that each dose of powder can be dispensed through a separate duct or nozzle.