Patents by Inventor Stephen E. Feinberg
Stephen E. Feinberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230383228Abstract: An apparatus (e.g., for cell culture for in vitro growth of tissues and/or organs) includes a base, a plate on the base, and a removable barrier component on the plate. The removable barrier component is configured to at least partially define a first region. The removable barrier component includes a bottom surface and a top surface. The bottom surface configured to be in contact with the plate. The top surface is opposite the bottom surface. The press is configured to engage the top surface of the removable barrier component to apply a predetermined pressure to the removable barrier component. The removable barrier component is between the press and the plate. A joint between the plate and the removable barrier component may be substantially impermeable to live cells. The apparatus may further include a removable cover that engages the base to enclose the plate, the removable barrier component, and the press.Type: ApplicationFiled: May 26, 2023Publication date: November 30, 2023Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Stephen E. FEINBERG, James Brian WASHINGTON, Roger W. MULDER, Allen SAMUELS, Cynthia L. MARCELO
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Patent number: 11793644Abstract: Provided are biocompatible and implantable scaffolds for treating a tissue defect, such as a bone gap. The scaffolds can have a modular design comprising a tissue scaffold rack designed to accommodate one or more modules. Also provided are methods for fabrication and use of such scaffolds.Type: GrantFiled: October 28, 2019Date of Patent: October 24, 2023Assignee: DePuy Synthes Products, Inc.Inventors: Scott J. Hollister, Stephen E. Feinberg, William L. Murphy, Leenaporn Jongpaiboonkit, James R. Adox, Francesco Migneco
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Publication number: 20220168469Abstract: The present disclosure provides, in various aspects, a method of forming a prefabricated innervated pre-vascularized pre-laminated (PIPP) flap having a stoma or lumen. The method includes providing a cell construct including skin cells and/or mucosa cells. The method further includes forming an integrated in vivo composite at a donor site by grafting the cell construct onto a muscle. The method further includes stabilizing the composite on an obturator component. The method further includes developing a microvascular system in the composite by retaining it in vivo at the donor site for a predetermined period of time. The method further includes removing the obturator component from the stoma or lumen. In certain aspects, the present disclosure also provides a method of restoring a defect including damaged or surgically removed soft tissue using a PIPP flap. In certain aspect, the present disclosure also provides an obturator component for maintaining the stoma or lumen.Type: ApplicationFiled: December 2, 2021Publication date: June 2, 2022Inventors: Stephen E. FEINBERG, Shiuhyang KUO, James Brian WASHINGTON
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Publication number: 20200281725Abstract: Provided are biocompatible and implantable scaffolds for treating a tissue defect, such as a bone gap. The scaffolds can have a modular design comprising a tissue scaffold rack designed to accommodate one or more modules. Also provided are methods for fabrication and use of such scaffolds.Type: ApplicationFiled: May 26, 2020Publication date: September 10, 2020Inventors: Scott J. Hollister, Stephen E. Feinberg, William L. Murphy, Leenaporn Jongpaiboonkit, James R. Adox, Francesco Migneco
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Publication number: 20200121462Abstract: Provided are biocompatible and implantable scaffolds for treating a tissue defect, such as a bone gap. The scaffolds can have a modular design comprising a tissue scaffold rack designed to accommodate one or more modules. Also provided are methods for fabrication and use of such scaffolds.Type: ApplicationFiled: October 28, 2019Publication date: April 23, 2020Inventors: Scott J. Hollister, Stephen E. Feinberg, William L. Murphy, Leenaporn Jongpaiboonkit, James R. Adox, Francesco Migneco
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Patent number: 10500053Abstract: Provided are biocompatible and implantable scaffolds for treating a tissue defect, such as a bone gap. The scaffolds can have a modular design comprising a tissue scaffold rack designed to accommodate one or more modules. Also provided are methods for fabrication and use of such scaffolds.Type: GrantFiled: March 26, 2018Date of Patent: December 10, 2019Assignee: DePuy Synthes Products, Inc.Inventors: Scott J. Hollister, Stephen E. Feinberg, William L. Murphy, Leenaporn Jongpaiboonkit, James R. Adox, Francesco Migneco
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Publication number: 20190000628Abstract: Provided are biocompatible and implantable scaffolds for treating a tissue defect, such as a bone gap. The scaffolds can have a modular design comprising a tissue scaffold rack designed to accommodate one or more modules. Also provided are methods for fabrication and use of such scaffolds.Type: ApplicationFiled: March 26, 2018Publication date: January 3, 2019Inventors: Scott J. Hollister, Stephen E. Feinberg, William L. Murphy, Leenaporn Jongpaiboonkit, James R. Adox, Francesco Migneco
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Patent number: 9943410Abstract: Provided are biocompatible and implantable scaffolds for treating a tissue defect, such as a bone gap. The scaffolds can have a modular design comprising a tissue scaffold rack designed to accommodate one or more modules. Also provided are methods for fabrication and use of such scaffolds.Type: GrantFiled: February 28, 2012Date of Patent: April 17, 2018Assignee: DePuy Synthes Products, Inc.Inventors: Scott J. Hollister, Stephen E. Feinberg, William L. Murphy, Leenaporn Jongpaiboonkit, James R. Adox, Francesco Migneco
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Patent number: 8835169Abstract: In accordance with some preferred embodiments, without limitation, the present invention comprises compositions, methods and systems for preparation of stem-cell enriched cell populations from sources of biological materials by sorting cell types in relation to size.Type: GrantFiled: October 24, 2005Date of Patent: September 16, 2014Assignee: The Regents of the University of MichiganInventors: Stephen E. Feinberg, Kenji Izumi, Cynthia L. Marcelo, Yasushi Fujimori
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Patent number: 8478422Abstract: The present invention is generally directed to a method for regulating cellular and tissue physiology, a device for practicing the method, and a process for fabricating the device. In general the process comprises the steps of providing at least one patterned electrode, providing a least one cell, placing the at least one electrode in electrical communication with the at least one cell, and applying a voltage to the electrode thereby delivering an effective amount of a patterned electric field or current thus regulating the physiology and/or growth of the at least one cell.Type: GrantFiled: September 21, 2006Date of Patent: July 2, 2013Assignees: The Ohio State University, The Regents of the University of MichiganInventors: Arthur J. Epstein, Stephen E. Feinberg, Derek J. Hansford, Yanyin Yang
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Publication number: 20120330423Abstract: Methods for the engineering and preparation of intervertebral disc repair scaffolds and articulating joint repair scaffolds are disclosed. The methodology utilizes either magnetic resonance images or combined magnetic resonance and computed tomography images as a template for creating either the intervertebral scaffold or the joint repair scaffold (e.g., osteochondral scaffold) with fixation to the underlying bone. The disc scaffold design may include an outer annulus that may contain desired structures and a central nucleus pulposus region that could either contain a designed microstructure or a contained hydrogel. The osteochondral scaffold may include a bone compartment interface with a cartilage compartment. The bone compartment may interface with a cutout portion of the bone through fixation components. Different microstructure designs may be created for the bone and cartilage compartment to represent desired mechanical and mass transport properties.Type: ApplicationFiled: August 27, 2012Publication date: December 27, 2012Inventors: Chia-Ying Lin, Frank LaMarca, Stephen E. Feinberg, William L. Murphy, James R. Adox, Scott J. Hollister
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Publication number: 20120271418Abstract: Provided are biocompatible and implantable scaffolds for treating a tissue defect, such as a bone gap. The scaffolds can have a modular design comprising a tissue scaffold rack designed to accommodate one or more modules. Also provided are methods for fabrication and use of such scaffolds.Type: ApplicationFiled: February 28, 2012Publication date: October 25, 2012Applicant: TISSUE REGENERATION SYSTEMS, INC.Inventors: Scott J. Hollister, Stephen E. Feinberg, William L. Murphy, Leenaporn Jongpaiboonkit, James R. Adox, Francesco Migneco
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Patent number: 8275594Abstract: Methods for the engineering and preparation of intervertebral disc repair scaffolds and articulating joint repair scaffolds are disclosed. The methodology utilizes either magnetic resonance images or combined magnetic resonance and computed tomography images as a template for creating either the intervertebral scaffold or the joint repair scaffold (e.g., osteochondral scaffold) with fixation to the underlying bone. The disc scaffold design may include an outer annulus that may contain desired structures and a central nucleus pulposus region that could either contain a designed microstructure or a contained hydrogel. The osteochondral scaffold may include a bone compartment interface with a cartilage compartment. The bone compartment may interface with a cutout portion of the bone through fixation components. Different microstructure designs may be created for the bone and cartilage compartment to represent desired mechanical and mass transport properties.Type: GrantFiled: October 29, 2007Date of Patent: September 25, 2012Assignees: The Regents of the University of Michigan, Wisconsin Alumni Research FoundationInventors: Chia-Ying Lin, Frank LaMarca, Stephen E. Feinberg, William L. Murphy, James R. Adox, Scott J. Hollister
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Patent number: 7887829Abstract: The present invention discloses a composite made of a layer of epithelial cells cultured together with a dermal matrix in a culture medium, which is free of BPE. The dermal matrix is a substantially non-immunogenic human dermis. Also disclosed is an enhanced composite where a biological agent has been introduced into the epithelial cells. The invention also comprises methods of making and implanting both the composite and the enhanced composite in an animal. A method of treating disease or injury through the use of the disclosed composites is also part of the present invention.Type: GrantFiled: October 28, 2002Date of Patent: February 15, 2011Assignee: The Regents of the University of MichiganInventors: Stephen E. Feinberg, Cynthia L. Marcelo, Blake J. Roessler
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Publication number: 20100160999Abstract: The present invention is generally directed to a method for regulating cellular and tissue physiology, a device for practicing the method, and a process for fabricating the device. In general the process comprises the steps of providing at least one patterned electrode, providing a least one cell, placing the at least one electrode in electrical communication with the at least one cell, and applying a voltage to the electrode thereby delivering an effective amount of a patterned electric field or current thus regulating the physiology and/or growth of the at least one cell.Type: ApplicationFiled: September 21, 2006Publication date: June 24, 2010Inventors: Arthur J Epstein, Stephen E. Feinberg, Derek J. Hansford, Yanyin Yang
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Publication number: 20090192514Abstract: An osteogenesis distraction device for securement to separate bone segments in the body of a patient and operative to generate new bone between said bone segments by the gradual application of a distraction force, the device comprising attachment members securable to separate bone segments and moveable in relation to each other to generate a distraction force, a power source for powering relative movement of the attachment members, and wherein the entire device, including the attachment members and power source, is dimensioned for implantation entirely subdermally in the body of a patient.Type: ApplicationFiled: October 9, 2008Publication date: July 30, 2009Inventors: Stephen E. Feinberg, Ann Marie Sastry, Myoungdo Chung
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Publication number: 20080195211Abstract: Methods for the engineering and preparation of intervertebral disc repair scaffolds and articulating joint repair scaffolds are disclosed. The methodology utilizes either magnetic resonance images or combined magnetic resonance and computed tomography images as a template for creating either the intervertebral scaffold or the joint repair scaffold (e.g., osteochondral scaffold) with fixation to the underlying bone. The disc scaffold design may include an outer annulus that may contain desired structures and a central nucleus pulposus region that could either contain a designed microstructure or a contained hydrogel. The osteochondral scaffold may include a bone compartment interface with a cartilage compartment. The bone compartment may interface with a cutout portion of the bone through fixation components. Different microstructure designs may be created for the bone and cartilage compartment to represent desired mechanical and mass transport properties.Type: ApplicationFiled: October 29, 2007Publication date: August 14, 2008Inventors: Chia-Ying Lin, Frank LaMarca, Stephen E. Feinberg, William L. Murphy, James R. Adox, Scott J. Hollister