Patents by Inventor Stephen E. Karpiak

Stephen E. Karpiak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-acylated 5-hydroxytryptophan amide derivatives
    Patent number: 4658038
    Abstract: Analgesia-effecting 5-hydroxytryptophan derivatives are disclosed of the formulae: ##STR1## wherein R is selected from the group consisting of C.sub.2 -C.sub.16 alkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.2 -C.sub.16 alkenyl, C.sub.2 -C.sub.16 alkynyl, aryl containing up to 14 carbon atoms, and arylalkyl containing up to 20 carbon atoms;R.sup.2 and R.sup.2a are each H or R, as defined above;R.sup.3 and R.sup.3a are each H or alkyl containing from 1 to 4 carbons;R.sup.4 and R.sup.4a are each H or alkyl containing from 1 to 4 carbons;and their non-toxic, pharmacologically acceptable acid addition salts.
    Type: Grant
    Filed: November 13, 1984
    Date of Patent: April 14, 1987
    Assignees: Research Foundation for Mental Hygiene, Inc., Yeda Research and Development Co. Ltd.
    Inventors: Hadassah Tamir, Stephen E. Karpiak, Meir Wilchek
  • N-hexanoyl to n-heptadecanoyl 5-hydroxy tryptophan-5-hydroxytryptophanamides and use as analgesics
    Patent number: 4482567
    Abstract: Analgesia-effecting 5-hydroxytryptophan derivatives are disclosed of the formulae: ##STR1## wherein R is selected from the group consisting of C.sub.2 -C.sub.16 alkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.2 -C.sub.16 alkenyl, C.sub.2 -C.sub.16 alkynyl, aryl containing up to 14 carbon atoms, and arylalkyl containing up to 20 carbon atoms;R.sup.1 and R.sup.1a are each H or methyl;R.sup.2 and R.sup.2a are each H or R, as defined above;R.sup.3 and R.sup.3a are each H or alkyl containing from 1 to 4 carbons;R.sup.4 and R.sup.4a are each H or alkyl containing from 1 to 4 carbons;and their non-toxic, pharmacologically acceptable acid addition salts.
    Type: Grant
    Filed: October 7, 1982
    Date of Patent: November 13, 1984
    Assignees: Research Foundation for Mental Hygiene, Inc., Yeda Research and Development Co. Ltd.
    Inventors: Hadassah Tamir, Stephen E. Karpiak, Meir Wilchek