Abstract: Processes and intermediates for preparing fluoroketolide compounds are described herein.

Abstract: Neat 4-azidobutylamine and sails of 4-azidobutylamine and processes for producing the same are described herein. Amines represent a large class of organic compounds containing a basic nitrogen atom having a lone pair of electrons and one or more substituent groups. Many amines are used as precursors and feedstocks in a wide variety of industries such as textiles, agriculture, plastics, and pharmaceuticals. One such amine is 4-azidobutylamine, N3-(CH2)4NH2, an amine of butane that also includes an azide.

Abstract: Provided is an HIV fusion inhibitor peptide having an amino acid sequence of any one of SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, or SEQ ID NO:15; and provided is a pharmaceutical composition comprising a HIV fusion inhibitor peptide and one or more of a pharmaceutically acceptable carrier and macromolecular carrier, and uses and methods of treatment provided by these compositions.

Abstract: Provided is an HIV fusion inhibitor peptide having an amino acid sequence of any one of SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, or SEQ ID NO:15; and provided is a pharmaceutical composition comprising a HIV fusion inhibitor peptide and one or more of a pharmaceutically acceptable carrier and macromolecular carrier, and uses and methods of treatment provided by these compositions.

Abstract: Provided herein are methods for synthesis of peptides. In particular, provided herein are methods of synthesis for therapeutic antiviral peptides.

Abstract: Provided is an HIV fusion inhibitor peptide having an amino acid sequence of any one of SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, or SEQ ID NO:15; and provided is a pharmaceutical composition comprising a HIV fusion inhibitor peptide and one or more of a pharmaceutically acceptable carrier and macromolecular carrier, and uses and methods of treatment provided by these compositions.

Abstract: Provided is an HIV fusion inhibitor peptide having an amino acid sequence of any one of SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, or SEQ ID NO:15; and provided is a pharmaceutical composition comprising a HIV fusion inhibitor peptide and one or more of a pharmaceutically acceptable carrier and macromolecular carrier, and uses and methods of treatment provided by these compositions.

Abstract: A system is disclosed for applying a graphics-imprinted skin to a substrate of expanded polyolefin foam. The system is used to create bodyboards and other foam devices with durable graphic images. The skin is made of a plurality of thin-film polyethylene layers adhesively bonded together. The outermost layer is a sheet of nonopaque (i.e., clear) polyethylene with graphic images imprinted on one side. The images are printed in reverse pattern and viewed through the polyethylene sheet from the other side. The nonopaque sheet is then adhesively bonded to an opaque backing sheet along the graphic-imprinted surface. The result is a flexible laminated skin material with visible graphics on one side. The skin material is then thermolaminated to the foam substrate with the graphics facing outwardly. A method of continuous fabrication is also disclosed.

Abstract: A generally trapezoidal fin (22) is pivotally fastened to a casing which can receive the entire fin, permitting total retraction of the fin. The casing is formed with at least one notch (42) for selectively positioning the fin relative to the casing. In a preferred embodiment, the fin is operated by a lever member (26) which has a knob (50) at its distal end for use in positioning the fin (22) from above.

Abstract: A floating, reclining lounge (10) including a mechanism to permit it to be easily adjusted in the aquatic environment without the need for manually applied lifting force. In one embodiment, the mechanism includes a slotted bracket (30) with resilient sockets which enable the seat of the lounge to be moved and secured in select positions of adjustment. In another embodiment, the mechanism include a slotted bracket (100) having a rack (110) and pinion (108) to facilitate such adjustment.

Abstract: Normally hydrophobic, polyethylene hollow fibers having contiguous microporosity are prepared by extruding a heated solution of a polyethylene and an ester from a hollow fiber spinnerette, simultaneously cooling and drawing the forming fibers to a ratio of up to 40 to 1, drawing the gelled fibers to an overall ratio of from about 1.5/1 to 800/1 and then removing the ester. The maximum pore radius ranges up to about 50A, and the fibers have gas permeabilities approaching 10.sup.-2 cc (STP) per cm.sup.2 per second per cm. Hg. transmembrane pressure differential. A significant increase in permeability over polyethylene hollow fibers made according to the teachings of the prior art is achieved.

Abstract: Normally hydrophobic, polyethylene hollow fibers having contiguous microporosity are prepared by extruding a heated solution of a polyethylene and an ester from a hollow fiber spinnerette, simultaneously cooling and drawing the forming fibers to a ratio of up to 40 to 1, drawing the gelled fibers to an overall ratio of from about 1.5/1 to 800/1 and then removing the ester. The maximum pore radius ranges up to about 50A, and the fibers have gas permeabilities approaching 10.sup.-.sup.2 cc (STP) per cm.sup.2 per second per cm. Hg. transmembrane pressure differential. A significant increase in permeability over polyethylene hollow fibers made according to the teachings of the prior art is achieved.