Abstract: A method comprising: receiving, over a network, wager information for a plurality of wager items, from a plurality of players, the wager item being a selection from some of several choices, then choosing at random a winning selection from the several choices, then continuing similar wager items for a plurality of rounds, and then awarding a prize to those players who, over all of the rounds, have selected at least a certain number of winning selections. The method further includes recording by player each player's selection for each round, aggregating data for the completed selection order of each player after all the rounds, this data being the path chosen by the player, and the selection order being the selection chosen after a given prior selection. The method then awards a prize in equal shares to those players who, over all the rounds, have selected the path chosen by a larger number of players.

Abstract: A device and methods of use and manufacture are disclosed for controlled diffusion of chemical substances of interest intraorally. The device includes ported structure formed of material that is substantially impermeable to the substance of interest, an inner wall of which defines a compartment communicating through the ports with the exterior of the device. A dispersed layer is formed in the compartment of material having limited permeability, the layer being formed so that contact is maintained with the inner wall across the ports after formation, the ports and the layer thus providing a region of permeability to diffusion of the chemical substance of interest. In use, either the chemical substance of interest or a composition capable of binding itself to the chemical substance of interest is placed in the compartment and the device is positioned in the mouth of a subject where it may remain for extended periods.

Abstract: A device for enabling a measurement of the time integral of concentrations of substances in a biological fluid, without the necessity to collect samples of that fluid, is disclosed for accomplishing time-integrated measurement of the freely-diffusable fraction of substances of interest by providing conditions under which the rate of accumulation of such substances by the device placed in intimate contact with the biological fluid is at all times proportional to their concentration.

Abstract: A method for obtaining a measurement of the time integral of concentrations of substances in a biological fluid, without the necessity to collect samples of that fluid, and a device useful in the practice of that method. The concepts accomplish time-integrated measurement of the freely-diffusable fraction of substances of interest by providing conditions under which the rate of accumulation of such substances by a device placed in intimate contact with the biological fluid is at all times proportional to their concentration.