Abstract: A catheter includes a pressure actuated seal within a manifold. A catheter body is coupled with the manifold, and a manifold lumen and catheter lumen are configured to receive pressurized fluids. The pressure actuated seal includes a pressure actuated seal element having a seal element lumen. The seal element lumen is in communication with the manifold and catheter lumens. The pressure actuated seal element is deformable between an open configuration and a sealed configuration. In the sealed configuration, the pressurized fluid in the manifold presses on the pressure actuated seal element along a first seal face. The pressure actuated seal element compresses inwardly around the seal element lumen according to the pressure of the pressurized fluid. In the open configuration, the pressure actuated seal element relaxes in the absence of the pressurized fluid, and the seal element lumen is open and configured to allow passage of an instrument.

Abstract: The present invention pertains to a miniature flexible thrombectomy catheter having one or more flexible miniature noncollapsing tubular portions including pushable and torqueable structure for introduction into the smaller vessels in neurovascular regions. A jet body having an arcuate fluid jet emanator is incorporated in order to minimize size at the distal portion of a minimally sized catheter tube.

Abstract: A direct stream hydrodynamic catheter system is provided for the removal of thrombus, lesions and the like including provisions for the infusion of drugs, lysing fluids and the like into a blood vessel. Physician controlled high powered direct fluid jet streams emanate from a fluid jet emanator in the form of robust radially directed fluid jet streams to impinge upon and ablate difficult and strong thrombus or lesions within a blood vessel. Effluent aspiration is controlled by an exhaust regulator in the form of a roller pump, but effluent removal can be assistingly influenced by the fluid pressure associated with the radially directed fluid jet streams.

Abstract: Catheters including guidewire tubes having a limited length and methods of using the catheters are described. The catheters may be delivered over guidewires in procedures that are commonly referred to as rapid-exchange delivery.

Abstract: An intravascular emboli capture and retrieval system for intravascular embolism protection and embolism removal or maceration. Guidewire mounted proximally and distally located multiple opening filters are deployed within the vasculature and used to part, divide and macerate embolic debris and to capture such embolic debris within the confines thereof. A deployable flexible preformed memory shaped capture sleeve is alternatively used to collapse one or more filters and embolic debris therein for subsequent proximal withdrawal from the vasculature.

Abstract: A miniature cross stream thrombectomy catheter useful in small blood vessel thrombectomy procedures. An annulus near the distal end of the miniature cross stream thrombectomy catheter is formed between a hypo-tube and a proximally directed bore of a concentrically aligned flow director whereby jet orifices in the hypo-tube communicate with the annulus to direct jet flows of saline or other fluid around and about the annulus and to be directed proximally from the annulus to pass through one or more outflow orifices and thence to pass through one or more inflow orifices thereby creating an ablation flow therebetween which loosens and carries away thrombotic materials from the walls of a blood vessel.

Abstract: The present invention pertains to a miniature flexible thrombectomy catheter having one or more flexible miniature noncollapsing tubular portions including pushable and torqueable structure for introduction into the smaller vessels in neurovascular regions. A jet body having an arcuate fluid jet emanator is incorporated in order to minimize size at the distal portion of a minimally sized catheter tube.

Abstract: A miniature cross stream thrombectomy catheter useful in small blood vessel thrombectomy procedures. An annulus near the distal end of the miniature cross stream thrombectomy catheter is formed between a hypo-tube and a proximally directed bore of a concentrically aligned flow director whereby jet orifices in the hypo-tube communicate with the annulus to direct jet flows of saline or other fluid around and about the annulus and to be directed proximally from the annulus to pass through one or more outflow orifices and thence to pass through one or more inflow orifices thereby creating an ablation flow therebetween which loosens and carries away thrombotic materials from the walls of a blood vessel.

Abstract: The present invention pertains to a miniature flexible thrombectomy catheter having one or more flexible miniature noncollapsing tubular portions including pushable and torqueable structure for introduction into the smaller vessels in neurovascular regions. A jet body having an arcuate fluid jet emanator is incorporated in order to minimize size at the distal portion of a minimally sized catheter tube.

Abstract: The present invention pertains to a miniature flexible thrombectomy catheter having one or more flexible miniature noncollapsing tubular portions including pushable and torqueable structure for introduction into the smaller vessels in neurovascular regions. A jet body having an arcuate fluid jet emanator is incorporated in order to minimize size at the distal portion of a minimally sized catheter tube.

Abstract: A single operator exchange fluid jet thrombectomy device having an outer catheter assembly and separable and exchangeable components in the form of an inner catheter assembly allowing functioning as a rheolytic thrombectomy catheter or as a crossflow thrombectomy catheter. Embodiments include an outer catheter assembly common to any mode of usage having a guide catheter having a lumen through which a guidewire and the greater portion of a hypo-tube carrying a flow director are passed and advanced. For use as a rheolytic thrombectomy catheter, thrombus is dislodged, entrained, and broken into pieces by jets and evacuated through the lumen of the guide catheter. For use as a crossflow thrombectomy catheter, a flow director having outflow and inflow orifices is provided.

Abstract: A single operator exchange fluid jet thrombectomy method employing a single operator exchange fluid jet thrombectomy device having an outer catheter assembly and separable and exchangeable components in the form of an inner catheter assembly allowing functioning as a rheolytic thrombectomy catheter or as a crossflow thrombectomy catheter. The outer catheter assembly is common to any mode of usage and includes a guide catheter having a lumen through which a guidewire and the greater portion of a hypo-tube carrying a jet emanator and a flow director are passed and advanced. In the method, thrombus is dislodged, entrained, and broken into pieces by fluid jets and evacuated through the lumen of the guide catheter.