Patents by Inventor Stephen Evan Webber

Stephen Evan Webber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chiral cis-imidazolines
    Patent number: 7964724
    Abstract: and the pharmaceutically acceptable salts and esters thereof, wherein X1, X2, X3, Y1, Y2 and R are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and hence have anti proliferative activity.
    Type: Grant
    Filed: May 13, 2005
    Date of Patent: June 21, 2011
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Nader Fotouhi, Gregory Jay Haley, Klaus B. Simonsen, Binh Thanh Vu, Stephen Evan Webber
  • Cis-imidazolines
    Patent number: 7705007
    Abstract: There are provided compounds of the formula I wherein R, V1, V2 and Ring A are described herein. The compounds exhibit anticancer activity.
    Type: Grant
    Filed: January 17, 2007
    Date of Patent: April 27, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Nader Fotouhi, Gregory Jay Haley, Klaus B. Simonsen, Binh Thanh Vu, Stephen Evan Webber
  • Cis-imidazolines
    Patent number: 7579368
    Abstract: There are presented compounds of the formula or pharmaceutically acceptable salts thereof, wherein Y1, Y2, X1, X2, X3 and R are as described in this application. These compounds are believed to inhibit MDM2-p53 interaction and as such the compounds will have anti-hyperproliferative cellular activity.
    Type: Grant
    Filed: March 13, 2006
    Date of Patent: August 25, 2009
    Assignee: Hoffman-La Roche Inc.
    Inventors: Nader Fotouhi, Gregory Jay Haley, Klaus B. Simonsen, Binh Thanh Vu, Stephen Evan Webber
  • CHIRAL CIS-IMIDAZOLINES
    Publication number: 20090143364
    Abstract: and the pharmaceutically acceptable salts and esters thereof, wherein X1, X2, X3, Y1, Y2 and R are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and hence have anti proliferative activity.
    Type: Application
    Filed: February 5, 2009
    Publication date: June 4, 2009
    Inventors: Nader Fotouhi, Gregory Jay Haley, Klaus B. Simonsen, Binh Thanh Vu, Stephen Evan Webber
  • Tricyclic inhibitors of poly(ADP-ribose) polymerases
    Patent number: 7429578
    Abstract: Compounds of the formula below are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapeutics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and neurodegenerative disease. As cancer therapeutics, the compounds of the invention may be used, e.g., in combination with cytotoxic agents and/or radiation.
    Type: Grant
    Filed: September 6, 2005
    Date of Patent: September 30, 2008
    Assignees: Agouron Pharmaceuticals, Inc., Cancer Research Campaign Technology Limited
    Inventors: Stephen Evan Webber, Stacie S. Canan-Koch, Jayashree Tikhe, Lars Henrik Thoresen
  • Cis-imidazolines
    Patent number: 7425638
    Abstract: The present invention provides compounds according to formula I having the designations provided herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: September 16, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Gregory Jay Haley, Norman Kong, Emily Aijun Liu, Klaus B. Simonsen, Binh Thanh Vu, Stephen Evan Webber
  • Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
    Patent number: 6995142
    Abstract: Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also provided.
    Type: Grant
    Filed: November 6, 2002
    Date of Patent: February 7, 2006
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Peter Scott Dragovich, Stephen Evan Webber, Thomas Jay Prins, Ru Zhou, Joseph Timothy Marakovits, Theodore O. Johnson, Jr.
  • Tricyclic inhibitors of poly(ADP-ribose) polymerases
    Patent number: 6977298
    Abstract: Compounds of the formula below are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapeutics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and neurodegenerative disease. As cancer therapeutics, the compounds of the invention may be used, e.g., in combination with cytotoxic agents and/or radiation.
    Type: Grant
    Filed: December 3, 2004
    Date of Patent: December 20, 2005
    Assignees: Agouron Pharmacetucals, Inc., Cancer Research Campaign Technology Limited
    Inventors: Stephen Evan Webber, Stacie S. Canan-Koch, Jayashree Tikhe, Lars Henrik Thoresen
  • Antipicornaviral compounds, their preparation and use
    Patent number: 6906198
    Abstract: Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also provided.
    Type: Grant
    Filed: January 5, 1999
    Date of Patent: June 14, 2005
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Peter Scott Dragovich, Stephen Evan Webber, Thomas Jay Prins, Ru Zhou, Joseph Timothy Marakovits, Theodore O. Johnson, Jr., Jayashree Girish Tikhe
  • Cis-imidazolines
    Publication number: 20040259884
    Abstract: The present invention provides compounds according to formula I 1
    Type: Application
    Filed: June 14, 2004
    Publication date: December 23, 2004
    Inventors: Gregory Jay Haley, Norman Kong, Emily Aijun Liu, Klaus B. Simonsen, Binh Thanh Vu, Stephen Evan Webber
  • Antipicornaviral compounds and compositons, their pharmaceutical uses, and materials for their synthesis
    Publication number: 20030130204
    Abstract: Peptido and peptidomimetic compounds of the formula: 1
    Type: Application
    Filed: November 6, 2002
    Publication date: July 10, 2003
    Inventors: Peter Scott Dragovich, Stephen Evan Webber, Thomas Jay Prins, Ru Zhou, Joseph Timothy Marakovits, Theodore O. Johnson
  • Tricyclic inhibitors of poly(ADP-ribose) polymerases
    Publication number: 20030078254
    Abstract: Compounds of the formula below are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapeutics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and neurodegenerative disease.
    Type: Application
    Filed: October 2, 2002
    Publication date: April 24, 2003
    Inventors: Stephen Evan Webber, Stacie S. Canan-Koch, Jayashree Tikhe, Lars Henrik Thoresen
  • Tricyclic inhibitors of poly(ADP-ribose) polymerases
    Patent number: 6548494
    Abstract: Compounds of the formula shown below are poly(ADP-ribosyl)transferase inhibitors: Such compounds are useful as therapeutics in treating cancers and in ameliorating the effects of stroke, head trauma, and neurodegenerative disease.
    Type: Grant
    Filed: August 31, 2000
    Date of Patent: April 15, 2003
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Stephen Evan Webber, Donald James Skalitzky, Jayashree Girish Tikhe, Robert Arnold Kumpf, Joseph Timothy Marakovits, Brian Walter Eastman
  • Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
    Patent number: 6534530
    Abstract: Compounds of the formula: where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.
    Type: Grant
    Filed: August 3, 2000
    Date of Patent: March 18, 2003
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Peter Scott Dragovich, Ru Zhou, Stephen Evan Webber, Thomas J. Prins, Siegfried Heinz Reich, Susan E. Kephart, Yuanjin Rui
  • Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
    Patent number: 6531452
    Abstract: Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also provided.
    Type: Grant
    Filed: April 29, 1999
    Date of Patent: March 11, 2003
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Peter Scott Dragovich, Stephen Evan Webber, Thomas Jay Prins, Ru Zhou, Joseph Timothy Marakovits, Theodore O. Johnson, Jr.
  • Tricyclic inhibitors of poly(ADP-ribose) polymerases
    Patent number: 6495541
    Abstract: Compounds of the formula below are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapuetics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and nuerodegenerative disease. As cancer therapuetics, the compounds of the invention may be used, e.g., in combination with cytotoxic agents and/or radiation.
    Type: Grant
    Filed: January 10, 2000
    Date of Patent: December 17, 2002
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Stephen Evan Webber, Stacie S. Canan-Koch, Jayashree Tikhe, Lars Henrik Thoresen