Abstract: There are presented compounds of the formula or pharmaceutically acceptable salts thereof, wherein Y1, Y2, X1, X2, X3 and R are as described in this application. These compounds are believed to inhibit MDM2-p53 interaction and as such the compounds will have anti-hyperproliferative cellular activity.

Abstract: and the pharmaceutically acceptable salts and esters thereof, wherein X1, X2, X3, Y1, Y2 and R are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and hence have anti proliferative activity.

Abstract: Catheters for performing therapeutic and diagnostic procedures within a body, including human or animal body cavities or lumens, and methods for use. One or more distancing member of the catheter can be used to position a sensor or a therapeutic device a minimum distance from a wall of a lumen or cavity. The catheter can include means for actively or passively controlling or modulating its position within the lumen or cavity during a procedure. Methods for using the catheter include nonocclusive deployment in the human gastrointestinal tract for phototherapy procedures, delivering electromagnetic radiation substantially homogeneously or in a desired pattern to the interior of a lumen.

Abstract: Compounds of the formula below are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapeutics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and neurodegenerative disease. As cancer therapeutics, the compounds of the invention may be used, e.g., in combination with cytotoxic agents and/or radiation.

Abstract: The present invention provides compounds according to formula I having the designations provided herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity.

Abstract: Aspects of the invention can provide a method of effectively observing the photodecomposition process of a monolayer in real time. The invention can provide a method of observing the decomposition process of a monolayer when the monolayer is irradiated with UV rays, where the structure of the constituent molecule of the monolayer in an ultrahigh vacuum atmosphere and an oxygen-containing atmosphere respectively can be measured by a molecular structure measuring device during the UV irradiation. The invention can also provide a method of controlling the degree of surface decomposition of the monolayer that controls the ozone concentration accompanying the UV irradiation based on observation results obtained by using the observation method. The invention can further provide a method of patterning the monolayer that employs the control method.

Abstract: Physically flexible radiation-emitting probes and associated illumination methods and systems for delivering radiation or light to the interior of a lumen or cavity. Light-emitting devices are immersed in a flowing liquid coolant within a probe to provide high light output power, and convoluted electrical power buss structures provide physical flexibility of a probe about a longitudinal axis. The probes can be configured for delivering light to the interior of any lumen including for performing therapeutic medical procedures at locations in body lumens including the interior of the human gastrointestinal tract.

Abstract: An endoscopic device including an elongate member having opposite ends, and a clevis attached to one end of the opposite ends. The clevis includes a barrel having at least one slot longitudinally extending completely through the barrel. The device includes a pair of jaws mounted on the clevis for pivotal movement. Each of the jaws has an end opposite the elongate member. The device includes an actuator member operatively connected to the pair of jaws for moving the jaws between a closed position in which the end of the corresponding jaw is positioned adjacent the other jaw and an open position in which an end of the jaw is spaced from the other jaw.

Abstract: A stamped jaw for use in an endoscopic device. The jaw includes a cup having opposite side walls extending longitudinally along the jaw, and an end wall extending between the side walls. The opposite side walls have a first tooth profile and the end wall has a second tooth profile different from the first tooth profile.

Abstract: An end effector for use in an endoscopic device including a cup, and a hinge extension formed separately from the cup and connected to the cup. The hinge extension has a pivot for pivotally connecting the end effector to an identical second end effector.

Abstract: A stamped jaw for use in an endoscopic device including a cup having opposite side walls extending longitudinally along the jaw spaced equally from and on opposite sides of a longitudinally extending median plane, and an end wall extending between the side walls. The jaw also includes a hinge extension attached to the cup having a hinge pin opening adapted to receive a hinge pin to pivotally connect the jaw with an identical second jaw, an inner face surrounding the hinge pin opening extending along the median plane, and an outer face positioned to abut a clevis when assembled in the endoscopic device.

Abstract: Physically flexible radiation-emitting probes and associated illumination methods and systems for delivering radiation or light to the interior of a lumen or cavity. Light-emitting devices are immersed in a flowing liquid coolant within a probe to provide high light output power, and convoluted electrical power buss structures provide physical flexibility of a probe about a longitudinal axis. The probes can be configured for delivering light to the interior of any lumen including for performing therapeutic medical procedures at locations in body lumens including the interior of the human gastrointestinal tract.

Abstract: Physically flexible radiation-emitting probes and associated illumination methods and systems for delivering radiation or light to the interior of a lumen or cavity. Light-emitting devices are immersed in a flowing liquid coolant within a probe to provide high light output power, and convoluted electrical power buss structures provide physical flexibility of a probe about a longitudinal axis. The probes can be configured for delivering light to the interior of any lumen including for performing therapeutic medical procedures at locations in body lumens including the interior of the human gastrointestinal tract.

Abstract: A medical-balloon inflator includes a pump piston assembly, a movable pivot, and an actuator handle. The actuator handle is operatively connected to the movable pivot and is adapted to translate the pump piston assembly to inflate or inflatingly pressurize a medical balloon when the actuator handle is rotated an angular distance about the movable pivot by a user.

Abstract: Physically flexible radiation-emitting probes and associated illumination methods and systems for delivering radiation or light to the interior of a lumen or cavity. Light-emitting devices are immersed in a flowing liquid coolant within a probe to provide high light output power, and convoluted electrical power buss structures provide physical flexibility of a probe about a longitudinal axis. The probes can be configured for delivering light to the interior of any lumen including for performing therapeutic medical procedures at locations in body lumens including the interior of the human gastrointestinal tract.

Abstract: An insertion tool for use in inserting a guide wire into a guide wire lumen of a catheter for use in a lumen of an endoscope. The insertion tool includes a main body having a main lumen and a funnel-shaped extension connected to and disposed atop the main body. The funnel-shaped extension having a funnel lumen. The funnel lumen has a top opening and a bottom opening. The funnel lumen tapering from the top opening to the bottom opening. The bottom opening positioned and sized to communicate with the guide wire lumen of the catheter such that, when the catheter is disposed in the main lumen, the guide wire may be easily inserted into the top opening of the funnel lumen and into the guide wire lumen of the catheter.

Abstract: Context-aware and location-aware cellular phones and methods are described. In one embodiment, cellular phones are configured to wirelessly receive information that pertains to their current context or location. The phones then automatically use the information to modify one or more cellular phone behaviors, e.g. by turning the phone off, changing the ringer's pitch, or placing the phone in a vibrate mode. In one particular embodiment, various location types are defined and have associated attributes that define a desired cellular phone behavior. One or more transmitters at a location for which a behavior is desired transmit information that pertains to the location's class type. The cell phones can carry an association of class types and their behaviors so that when the phones receive the class type information, they can automatically adjust their behavior.

Abstract: A conduit is provided to provide a bypass around a blockage in the coronary artery. The conduit is adapted to be positioned in the myocardium or heart wall to provide a passage for blood to flow between a chamber of the heart such as the left ventricle and the coronary artery, distal to the blockage. The stent is self-expanding or uses a balloon to expand the stent in the heart wall. Various attachment means are provided to anchor the stent and prevent its migration. In one embodiment, a conduit is provided having a distal top which is more preferably a ball top, wire top, flare top or flip-down top. These top configurations anchor the shunt at one end in the coronary artery.

Abstract: An application program interface (API), enables web development tools to interact directly with a hyperlink database subsystem. Tool developers use this API to design functionality that enables affiliates to log on to the hyperlink database system and generate merchant links. In response to requests from vendors' tools, the invention API uses the XML format to deliver requested hyperlink generation information. The requests are encrypted for users' privacy. The returned hyperlink generation information includes lists of merchants, lists of hyperlinks to the merchants web sites, the HTML code supporting the hyperlinks, and graphics for the links. Users implement hyperlinks by selecting among the choices returned in the response to the request and graphically placing (i.e., by drag and drop interaction) the resulting hyperlinks on subject web pages in a simple, error-free manner.

Abstract: The present invention provides for rendering graphics/image data at an electronic device that typically has limited resources. A video data steam is received at an electronic device, the video data stream including either user interface information or slideshow presentation data coded in a video codec format. A video processor of the electronic device is used to decode at least a portion of the video data stream into video frame data. A portion of the user interface or slideshow presentation is then displayed as video from data on a display of the electronic device.