Abstract: A cyber-threat defense system for a network including its email domain protects this network from cyber threats. Modules utilize machine learning models as well communicate with a cyber threat module. Modules analyze the wide range of metadata from the observed email communications. The cyber threat module analyzes with the machine learning models trained on a normal behavior of email activity and user activity associated with the network and in its email domain in order to determine when a deviation from the normal behavior of email activity and user activity is occurring. A mass email association detector determines a similarity between highly similar emails being i) sent from or ii) received by a collection of two or more individual users in the email domain in a substantially simultaneous time frame. Mathematical models can be used to determine similarity weighing in order to derive a similarity score between compared emails.

Abstract: A flavor delivery system including comminuted seeds, comminuted nuts, or mixtures thereof and a liquid flavor. A method for protecting a liquid flavor from oxidation by combining the liquid flavor with comminuted seeds, comminuted nuts, or mixtures thereof. A method for making a food product including adding a flavor delivery system including comminuted seeds, comminuted nuts, or mixtures thereof and a liquid flavor to an edible base. A food product including a flavor delivery system including comminuted seeds, comminuted nuts, or mixtures thereof, and a liquid flavor, and an edible base.

Abstract: Encapsulated active components for delivering a desired amount of the active component includes at least one active component encapsulated within a delivery vehicle obtained by cryogenically treating plant material. The active may be a desired flavor that is added to a consumable base to prepare a consumable product, such as food or beverage product, or to prepare an oral care product. Methods for making the delivery systems containing the active component and products containing the encapsulated active component delivery systems are also disclosed.

Abstract: A cutting and scoring guide for directing cutting baked goods in a rectangular pan into rectangular pieces is provided, the cutting and scoring guide comprising: a top; an at least two opposing walls extending from the top and having a locking groove on an inner side for releasable mating with a lip of a rectangular baking sheet; a series of equally spaced long slots in the top, the series of long slots in parallel relation with the opposing walls, each long slot extending from a vicinity of a first end to a vicinity of an opposing second end of the top; and a plurality of short slots arranged in a series of lines to define a gap between each short slot in the top, the lines equalling no more than half the number of long slots and being normal to the long slots.

Abstract: The present invention relates to methods for culturing progenitor cells to differentiate primarily into a single population of cells with the same phenotype, and to compositions thereof. In particular, it relates to methods for culturing liver progenitor cells to differentiate primarily into a single population of hepatocyte-like cells, and to compositions thereof.

Abstract: The present invention relates to methods for culturing progenitor cells to differentiate primarily into a single population of cells with the same phenotype, and to compositions thereof. In particular, it relates to methods for culturing liver progenitor cells to differentiate primarily into a single population of hepatocyte-like cells, and to compositions thereof.

Abstract: A method of desensitizing 5-HT2R signaling in the mammal is provided. The method comprises one or more of: 1) inhibiting CRFR1 activation of 5-HT2AR signaling by preventing trafficking of intracellular vesicles or blocking recycling of 5-HT2AR to the cell surface; 2) blocking PDZ binding motifs in the carboxyl-terminal tail domains of at least one of CRFR1, 5-HT2AR or 5-HT2CR; or 3) blocking the interaction of a 5-HT2R or a CRFR1 with a PDZ-domain-containing protein selected from the group consisting of MAGI-1 PDZ1, MAGI-2 PDZ1, MAGI-3 PDZ1, PSD95 PDZ 1&2, PSD95 PDZ3, CAL PDZ, SAP97 PDZ 1&2, PTPN13 PDZ 4&5, PDZK2 PDZ1, MPP3 PDZ, ERBIN PDZ and MUPP1 PDZ 12.

Abstract: An implant for sealing and/or healing a defect in an annulus having an area intended to encompass the defect. The implant is a textile strip that has a middle area which is intended to encompass the defect and which is an oriented low-density embroidered structure for guided tissue ingrowth and reinforcement and end areas adjacent to the middle area which are a high-density embroidered structure.

Abstract: Fiber optical gages that impart physical strain to an optical fiber by varying the tension applied axially to the fiber, which causes a change in the optical property of the light transmitted through the fiber. A gage carrier which provides the benefits of a metal carrier for ease of handling and mounting without degrading gage performance. At least a portion of the gage carrier is elastic with respect to expansion, compression or both along its longitudinal axis, thereby allowing for variation of the distance between the two points at which the gage carrier is attached to a test specimen. In a specific embodiment, the gage carrier functions as two independent rigid fiber fastening elements separated by a compliant or flexible member. The invention further provides fiber Bragg grating strain gages, which are particularly useful for monitoring ambient conditions and measuring physical properties and mechanical phenomena.

Abstract: A stabilizing agent for a hydroalkoxysilane such as triethoxysilane and trimethoxysilane characterized by comprising a carboxylate such as an alkali metal salt or an alkali earth metal salt of a carboxylic acid having 1 to 18 carbon atoms; a method for stabilizing a hydroalkoxysilane by combining it with a carboxylate; and a hydroalkoxysilane stabilized with a carboxylate.

Abstract: The invention relates generally to optical sensors that impart physical strain to an optical fiber by varying the tension applied axially to the fiber, which causes a change in the optical property of the light transmitted through the fiber. Methods, devices and device components for optical sensors are provided. The invention provides fiber holders capable of retaining a fiber under tension with little or no creep even in high temperature, high humidity environments. An exemplary fiber holder of the present invention provides superior retaining properties over epoxy and other adhesives while preserving the tensile strength of the original fiber. The invention further provides fiber holders and sensors, which are particularly useful for monitoring ambient conditions and measuring physical properties and mechanical phenomena.

Abstract: Described are methods of detecting G-protein coupled receptor (GPCR) activity in vivo and in vitro; methods of assaying GPCR activity; and methods of screening for GPCR ligands, G Protein-coupled receptor kinase (GRK) activity, and compounds that interact with components of the GPCR regulatory process.