Patents by Inventor Stephen Fox

Stephen Fox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cloning and expression of a novel acetylcholine-gated ion channel receptor subunit
    Patent number: 6013766
    Abstract: The present invention provides isolated nucleic acids encoding alpha9 nicotinic acetylcholine receptor subunit and receptor subunit protein encoded thereby. Also provided are vectors containing the invention nucleic acids, host cells transformed therewith, alpha9 nicotinic acetylcholine receptor subunit and functional nicotinic acetylcholine receptors comprising at least one alpha9 subunit expressed recombinantly in such host cells as well as transgenic non-human mammals that express the invention receptor subunit and mutants thereof. Receptors of the invention comprise at least one alpha9 nicotinic acetylcholine subunit and form cationic channels activated by acetylcholine, but blocked by nicotine and muscarine. The invention also provides methods for identifying compounds that modulate the ion channel activity of the functional invention receptors containing at least one invention subunit.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: January 11, 2000
    Assignee: The Salk Institute for Biological Studies
    Inventors: Ana Belen Elgoyhen, David S. Johnson, James Richard Boulter, Stephen Fox Heinemann
  • Recombinantly produced .beta.4 neuronal nicotinic acetylcholine receptor subunits
    Patent number: 5789196
    Abstract: The present invention discloses a new neuronal nicotinic acetylcholine receptor subunit, .beta.4. The new subunit can form functional combinations with other neuronal nicotinic acetylcholine receptor subunits, including, but not limited to, alpha2, alpha3, alpha4 and beta2. A cDNA clone containing the DNA sequences that encode the novel receptor subunit of the invention has been deposited with the American Type Culture Collection for patent purposes.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 4, 1998
    Inventors: Stephen Fox Heinemann, Robert Michael Duvoisin, Evan Samuel Deneris, James Warner Patrick
  • Cloning and expression of a novel acetylcholine-gated ion channel receptor subunit
    Patent number: 5683912
    Abstract: The present invention provides isolated nucleic acids encoding alpha9 nicotinic acetylcholine receptor subunit and receptor subunit protein encoded thereby. Also provided are vectors containing the invention nucleic acids, host cells transformed therewith, alpha9 nicotinic acetylcholine receptor subunit and functional nicotinic acetylcholine receptors comprising at least one alpha9 subunit expressed recombinantly in such host cells as well as transgenic non-human mammals that express the invention receptor subunit and mutants thereof. Receptors of the invention comprise at least one alpha9 nicotinic acetylcholine subunit and form cationic channels activated by acetylcholine, but blocked by nicotine and muscarine. The invention also provides methods for identifying compounds that modulate the ion channel activity of the functional invention receptors containing at least one invention subunit.
    Type: Grant
    Filed: July 21, 1994
    Date of Patent: November 4, 1997
    Assignee: The Salk Institute for Biological Studies
    Inventors: Ana Belen Elgoyhen, David S. Johnson, James Richard Boulter, Stephen Fox Heinemann