Abstract: Methods are disclosed for dissecting a mucosa and a submucosa from a muscularis propria from a region of an organ of a subject, wherein the organ is not the esophagus. In some embodiments, the organ is in the gastrointestinal tract. These methods include injecting submucosally into the organ of the subject a pharmaceutical composition comprising an extracellular matrix (ECM) hydrogel to form a cushion between the submucosa and the underlying muscularis propria at the region of the organ, wherein the ECM hydrogel has the following characteristics: a) a time to 50% gelation of less than 30 minutes at a temperature of about 37° C.; b) a flow viscosity suitable for infusion into the organ; and c) a stiffness of about 10 to about 400 Pascal (Pa).

Abstract: According to some embodiments, system and methods are provided, comprising receiving, from a network configuration module, configuration data at a network driver of a communication network; configuring the network driver based on the received configuration data; receiving one or more data packets at the network driver from an application; determining that one or more segregation features are present in the data packet based on the received configuration data; transmitting the one or more data packets based on the one or more segregation features; and controlling one or more operations of an installed product based on the transmitted one or more data packets. Numerous other aspects are provided.

Abstract: Compositions are disclosed herein that include an extracellular matrix (ECM) hydrogel and matrix bound nanovesicles (MBV). These compositions provide a synergistic effect and are of use for treating subjects.

Abstract: A system and method for generating a time-sensitive network schedule for a desired TSN includes defining a network topology of the desired TSN including at least a set of end nodes communicative connected by way of a set of switching nodes, defining a set of device parameters for each of the set of end nodes and each of the set of switching nodes of the desired TSN, determining, by a TSN scheduler, a TSN schedule for the desired TSN based on the defined network topology and the defined set of device parameters for each of the set of end nodes and each of the set of switching nodes, and generating a per-device configuration for each of the set of end nodes and each of the set of switching nodes of the desired TSN, based on the determined TSN schedule.

Abstract: Methods are disclosed herein for producing a mammalian acoustic extracellular matrix (ECM) hydrogel. In further embodiments, mammalian acoustic ECM hydrogels are disclosed that are produced using the disclosed methods. Also disclosed is a mammalian acoustic ECM hydrogel, wherein the hydrogel is thermoreversible. Methods of using these acoustic ECM hydrogels are also disclosed.

Abstract: Systems, methods, and other embodiments described herein relate to generating a time-sensitive network schedule for a time-sensitive network (TSN). In one embodiment, a method includes receiving a measured value of at least one environmental condition from at least one sensor. The method includes determining an impact of the measured value of the at least one environmental condition on at least one component of the TSN. The method includes programming a switching node based on at least the determined impact. The TSN includes a first end node, a second end node, and the switching node. The switching node is communicatively linked between the first end node and the second end node.

Abstract: Securing a file against user actions in a computer network includes processing a request for a file-directed action that identifies a user, a file, and a mode of file access. Generating a mediated covenant of association that defines constraints of the user action and is produced by node-by-node informatic convolution of a hierarchy of informational nodes present in profiles of the user, the file and the mode. Enforcing securing of the user actions with a computer security event-specific model based on an instance of trust derived from the covenant of association.

Abstract: A drive train for a wind-up injection device, comprises a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle coupled with a button, a rotationally drivable expelling mechanism, and a clutch element coupled with the torsional energy storage via the rotatable element and comprising a ratchet for maintaining the rotatable element at one of a number of discrete angular positions, wherein via the rotatable element, the clutch element is adapted to transmit a torque from the user handle to the torsional energy storage or from the torsional energy storage to the expelling mechanism, and wherein the ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage, and wherein the drive train is adapted to dampen torque peaks by a flexible impact portion in the area of the clutch element.

Abstract: A system includes a scheduling device of a data distribution service (DDS) that determines bandwidth for communication of time sensitive communications between devices using the DDS in a time sensitive network (TSN). The scheduling device determines available bandwidth for communication of non-time sensitive communications of the control system using the DDS in the TSN, and controls communication of both the time sensitive and non-time sensitive communications in the TSN. The system also includes a traffic shaper of the TSN that receives a communication change from the control system at the TSN. The scheduling device changes one or more of the bandwidth for the communication of the time sensitive communications or the available bandwidth for the communication of the non-time sensitive communications in the TSN without restarting at least one network device of the TSN and while ensuring communications of both the time sensitive communications and the non-time sensitive communications.

Abstract: An assembly for a drug delivery device is provided, the assembly comprising a feedback feature. The feedback feature is configured to indicate an end of the dispense operation to a user by giving an audible and/or tactile feedback.

Abstract: A respiratory mask system includes a mask interface and a headgear assembly. The headgear assembly is adjustable and comprised of an elastic portion, a non-elastic portion and a restriction mechanism configured to provide a force resisting movement of the non-elastic portion when the elastic portion is extended. There is a support beam coupled to the non-elastic portion and extending along a portion of the headgear that is curved along its longitudinal extent. In this way particular seal modules can be comfortably fitted to a user and any blow off force is mitigated. A particular example of the respiratory mask system includes provision for removable attachment between the seal and a mask frame, the mask frame and a yoke of the headgear; and between a conduit and the mask frame.

Abstract: A composition is disclosed herein that includes isolated ECM-derived nanovesicles and a pharmaceutically acceptable carrier. Methods are producing the ECM-derived nanovesicles are also disclosed. These ECM-derived nanovesicles can be included in pharmaceutical compositions, bioscaffolds, and devices. Methods for using these ECM-derived nanovesicles are provided.

Abstract: Securing a file against user actions in a computer network includes processing a request for a file-directed action that identifies a user, a file, and a mode of file access. Generating a mediated covenant of association that defines constraints of the user action and is produced by node-by-node informatic convolution of a hierarchy of informational nodes present in profiles of the user, the file and the mode. Enforcing securing of the user actions with a computer security event-specific model based on an instance of trust derived from the covenant of association.

Abstract: At a wireless communication network including subcomponents, a connection establishment message from a user equipment is received to connect the user equipment to the wireless communication network. From a wireless key distribution device, via. a. quantum communication channel, quantum encryption keys are received to encrypt and decrypt messages communicated with the user equipment, A network connection between the user equipment and the wireless communication network is established, and for at least one subcomponent of the wireless communication network: incoming communications from the user equipment or the other sub-components are decrypted using the quantum encryption keys and a quantum key distribution algorithm; and outgoing communication to the user equipment or the other subcomponents are encrypted using the quantum encryption keys and the quantum key distribution algorithm.

Abstract: A system and method obtains time-sensitive network application configuration information of an application communicatively coupled to a 5G network; shares the time-sensitive network application configuration information with a network slice configuration mechanism of the 5G network; determines, by the network slice configuration mechanism, a transmission schedule based on the time-sensitive network application configuration information; reserves an amount of network resources of the 5G network in accordance with the transmission schedule; and facilitates transmission of data from the application via the 5G network in accordance with the transmission schedule.

Abstract: A respiratory mask system includes a mask interface and a headgear assembly. The headgear assembly is adjustable and comprised of an elastic portion, a non-elastic portion and a restriction mechanism configured to provide a force resisting movement of the non-elastic portion when the elastic portion is extended. There is a support beam coupled to the non-elastic portion and extending along a portion of the headgear that is curved along its longitudinal extent. In this way particular seal modules can be comfortably fitted to a user and any blow off force is mitigated. A particular example of the respiratory mask system includes provision for removable attachment between the seal and a mask frame, the mask frame and a yoke of the headgear; and between a conduit and the mask frame.

Abstract: Techniques for communication over a communication network may include determining a plurality of network slices based on a plurality of services supported by the communication network, wherein each of the plurality of network slices supports communication of data associated with at least one service. A plurality of data streams may be configured within the communication network. Each data stream being configured in accordance with at least one of a plurality of time-sensitive network policies. A first data stream of the plurality of data streams corresponding to a first network slice of the plurality of network slices may be determined.

Abstract: A respiratory interface assembly includes a patient interface and a headgear arrangement. A seal or cushion of the interface assembly can include thickened portions positioned and arranged to improve sealing and/or user comfort. The headgear arrangement can be connectable to the nasal mask by a connection arrangement configured to provide stability to the nasal mask such that a forehead support is not required. The connection arrangement can inhibit or prevent improper connections. The headgear arrangement can have one or more resilient straps having a composite construction of an outer fabric and a plastic core. The outer fabric can be knitted. A rear portion of the headgear arrangement can include a knitted panel or a spacer fabric panel.

Abstract: A drive train for a wind-up injection device is described. The drive train includes a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle, a rotationally driveable expelling mechanism adapted to expel the liquid drug, and a clutch element coupled with the torsional energy storage via the rotatable element and including a ratchet for maintaining the rotatable element at one of a number of discrete angular positions against the torque of the torsional energy storage. The clutch element is adapted to transmit the torque from the user handle to the torsional energy storage, or alternatively from the torsional energy storage to the expelling mechanism. The ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage. The drive train is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.