Abstract: Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.

Abstract: A food product comprising a flavorant, allulose sugar; and cannabinoids is disclosed. The disclosure relates to a chocolate bar, including allulose sugar and CBD oil, and a method for making the same is disclosed.

Abstract: A lighting apparatus (10) is described for incorporation into a tiled wall, panel, ceiling, floor or similar structure (38,40). The apparatus comprises: a reflector unit (12, 14) that has at least one reflective surface (24, 26) for location behind the surface of the structure and an external light-transmissive face (14) for location generally flush with the surface of the structure; and means (28) for coupling an end of a fiber-optic cable (32) having a multiplicity of optical fibers (34) to the reflector unit behind the surface of the structure so that light projecting from the ends of the fibers enters the reflector unit and is reflected by the reflective surface(s) so as to provide substantially uniform illumination across the light-transmissive face. The reflector unit is formed with an external flange (20) generally parallel to the light-transmissive face.

Abstract: The invention provides a method and system for trading loans in real time. Loan applications, such as home mortgage loan applications, are made available electronically to receive bids from a plurality of potential lenders. A transaction server maintains a database of pending loan applications and their statuses, which is accessible over a communications channel, such as the Internet. Each party to a loan can search and modify the database consistent with their role in a transaction. The invention provides smart computerized administration that ensures personal preferences of the participating parties are enforced, errors and duplication is avoided, and information relating to accumulated data is available to the parties consistent with their roles.

Abstract: The online fire plan system includes a data entry, storage and retrieval module, and a fire plan wizard for guiding a user through the data entry, storage and retrieval. The data entry storage and retrieval module includes a web page layer, a business layer, and a data layer.