Abstract: Methods and compositions for the detection, identification, and quantification of compounds of interest in a sample are provided. The compositions and methods include arrays and kits comprising a population of surrogate antibodies that bind compounds of interest. The surrogate antibodies can be immobilized on to a solid support by means of an interaction between a recognition nucleotide sequence comprised in the surrogate antibody and a capture nucleotide sequence comprised in a capture probe attached to the solid support. Also provided are methods of using the arrays for research and clinical diagnostics, drug discovery, environmental testing, food testing, and testing for the use of agents of biological and chemical warfare.

Abstract: Methods and compositions for the modulation of an immune response are provided. Compositions comprise a bi-functional surrogate antibody molecule that interacts with a ligand of interest, wherein the bi-functional surrogate antibody further has attached thereto an immunomodulatory agent and/or a transporting agent. The compositions of the invention find use in a method for delivering an immunomodulatory agent to a ligand of interest. Further provided are methods for modulating an immune response in a subject against a ligand of interest. The method comprises administering a therapeutically effective amount of a bi-functional surrogate antibody of the invention. The methods of the invention also find use in improving the clinical outcome of a subject in need of a modulation in the immune response.

Abstract: A system for organizing access to a database that is distributed over an electronic network includes a system site on a dedicated server. A list of addresses to approved database sites on an electronic network stored on the system site is accessed by a user with a browser application. Reference cards permit the user to search and review the list of approved sites. In a first preferred embodiment, a request for access to a database site is made to the dedicated server. Access is denied for a non-approved site. An approved database is retrieved by the dedicated server. Each database link to an approved site is modified from direct to indirect to require all future access to be directed through the dedicated server. Links not in the list of approved sites will have their access denied. In a second, equally preferred embodiment, code defining a database location is removed at the dedicated server to de-activate links to non-approved database sites.