Abstract: The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.

Abstract: The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.

Abstract: The present invention provides systems and methods for the spectroscopic determination of the physical characteristics of the tissue under observation by an autofluorescence or other endoscope without the requirement of contacting the tissue directly. The optical probe contained in the endoscope itself is passive and may be either built into the endoscope or positioned in a biopsy channel of same. The spectroscopic information, combined with other information provided by the endoscope such as total fluorescence, improves the sensitivity and specificity of the identification of precancerous or cancerous lesions.

Abstract: The present invention relates to an optical contact sensor for a spectroscopic probe. The sensor detects contact of the distal end of a fiber optic probe to a surface being measured. The system can be used to correct Raman spectral measurements of tissue.

Abstract: The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.

Abstract: The present invention relates to systems and methods used in the measurement of arterial tissue. Optical probes in accordance with the invention use optical fibers to deliver and collect light using a sidelooking catheter. Diffused white light and fluorescence scattering is collected and processed to provide for improved artery wall diagnosis.

Abstract: The present invention related to a Raman artery probe diagnostic system and a method of using the system for the diagnosis of vascular disease. A side looking catheter having light delivery and collection optical fibers can deliver infrared light in a radial direction from the catheter to diagnose atherosclerotic plaques in the coronary arteries. A guidewire or guide catheter can be used to deliver the catheter to the region of interest within the artery to evaluate vulnerable plaques.