Abstract: The present invention relates to oral pharmaceutical compositions comprising nitisinone, or a pharmaceutically acceptable salt thereof, their use in the treatment of tyrosinemia, such as Hereditary Tyrosinemia type-1 (HT-1), or alkaptonuria. The compositions have improved stability characteristics. The invention also relates to processes for producing nitisinone.

Abstract: The present invention relates to oral pharmaceutical compositions comprising nitisinone, or a pharmaceutically acceptable salt thereof, their use in the treatment of tyrosinemia, such as Hereditary Tyrosinemia type-1 (HT-1), or alkaptonuria. The compositions have improved stability characteristics. The invention also relates to processes for producing nitisinone.

Abstract: A Common Channel Signaling Network such as the SS7 network is configured as a virtual signaling network, such that the network is shared in common among several users. Each user, which may be a private network operator, an ICO, a RBOC, a cellular mobile carrier, or an interexchange carrier, appears to control the signaling network and is enabled to use a wide variety of its capabilities to transmit and receive both trunk signaling messages and database messages to and from other networks connected to the virtual signaling network. The invention is implemented by interconnecting signal transfer points (STPs) within the virtual signaling network that operate in accordance with our invention with the SS7 switches and/or signal transfer points of other networks.

Abstract: A downhole fluid powered mover for use in earth bore holes having a fluid turbine to produce torque and a positive displacement fluid motor to regulate the speed of an output shaft connected to both turbine and motor. Alternate embodiments include an overrunning clutch to aid in start-up of the turbine and to prevent overspeed of the turbine.