Patents by Inventor Stephen G. Hoge

Stephen G. Hoge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alternative nucleic acid molecules containing reduced uracil content and uses thereof
    Patent number: 10072057
    Abstract: The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them. In some aspects, the disclosure provides mRNA wherein the uracil content has been modified and which may be particularly effective for use in therapeutic compositions, because they may benefit from both high expression levels and limited induction of the innate immune response. In some aspects, the disclosure provides methods for the production of pharmaceutical compositions including mRNA without reverse phase chromatography.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: September 11, 2018
    Assignee: ModernaTX, Inc.
    Inventors: Stephen G. Hoge, William Joseph Issa, Edward John Miracco, Jennifer Nelson, John Reynders, Matthew Stanton
  • LONG-LIVED POLYNUCLEOTIDE MOLECULES
    Publication number: 20180086816
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of long-lived polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: May 10, 2017
    Publication date: March 29, 2018
    Inventors: Stephen G. Hoge, Eric Yi-Chun Huang, Tirtha Chakraborty, Sayda M. Elbashir
  • COMPOSITIONS AND METHODS OF ALTERING CHOLESTEROL LEVELS
    Publication number: 20180036369
    Abstract: The present invention relates to compositions, methods and kits using polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: March 10, 2017
    Publication date: February 8, 2018
    Applicant: Moderna TX, Inc.
    Inventors: Stephen G. HOGE, Antonin DE FOUGEROLLES, Jeff Lynn ELLSWORTH
  • ALTERNATIVE NUCLEIC ACID MOLECULES CONTAINING REDUCED URACIL CONTENT AND USES THEREOF
    Publication number: 20180009866
    Abstract: The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them. In some aspects, the disclosure provides mRNA wherein the uracil content has been modified and which may be particularly effective for use in therapeutic compositions, because they may benefit from both high expression levels and limited induction of the innate immune response. In some aspects, the disclosure provides methods for the production of pharmaceutical compositions including mRNA without reverse phase chromatography.
    Type: Application
    Filed: July 21, 2017
    Publication date: January 11, 2018
    Inventors: Stephen G. Hoge, William Joseph Issa, Edward John Miracco, Jennifer Nelson, John Reynders, Matthew Stanton
  • TERMINALLY MODIFIED RNA
    Publication number: 20180000910
    Abstract: The invention relates to compositions and methods for the manufacture and optimization of modified mRNA molecules via optimization of their terminal architecture.
    Type: Application
    Filed: February 10, 2017
    Publication date: January 4, 2018
    Inventors: Tirtha CHAKRABORTY, Stephane BANCEL, Stephen G. HOGE, Atanu ROY, Antonin de FOUGEROLLES, Noubar B. AFEYAN
  • TOLEROGENIC COMPOSITIONS AND METHODS
    Publication number: 20170348415
    Abstract: The invention relates to tolerogenic compositions and methods for the preparation, manufacture and therapeutic use thereof.
    Type: Application
    Filed: September 3, 2015
    Publication date: December 7, 2017
    Inventors: Stephen G. HOGE, Eric Yi-Chun HUANG, Louis Saint Laurence O'DEA
  • Alternative nucleic acid molecules containing reduced uracil content and uses thereof
    Patent number: 9751925
    Abstract: The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them. In some aspects, the disclosure provides mRNA wherein the uracil content has been modified and which may be particularly effective for use in therapeutic compositions, because they may benefit from both high expression levels and limited induction of the innate immune response. In some aspects, the disclosure provides methods for the production of pharmaceutical compositions including mRNA without reverse phase chromatography.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: September 5, 2017
    Assignee: ModernaTX, Inc.
    Inventors: Stephen G. Hoge, William Joseph Issa, Edward John Miracco, Jennifer Nelson, John Reynders, Matthew Stanton
  • TERMINAL MODIFICATIONS OF POLYNUCLEOTIDES
    Publication number: 20170202979
    Abstract: The present invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides comprising at least one terminal modification.
    Type: Application
    Filed: July 17, 2015
    Publication date: July 20, 2017
    Inventors: Tirtha CHAKRABORTY, Stephen G. HOGE
  • TARGETED ADAPTIVE VACCINES
    Publication number: 20170173128
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules for targeted adaptive vaccines (TAVs).
    Type: Application
    Filed: December 8, 2014
    Publication date: June 22, 2017
    Inventors: Stephen G. Hoge, Eric Yi-Chun Huang
  • Terminally modified RNA
    Patent number: 9597380
    Abstract: The invention relates to compositions and methods for the manufacture and optimization of modified mRNA molecules via optimization of their terminal architecture.
    Type: Grant
    Filed: October 2, 2013
    Date of Patent: March 21, 2017
    Assignee: ModernaTx, Inc.
    Inventors: Tirtha Chakraborty, Stephane Bancel, Stephen G. Hoge, Atanu Roy, Antonin de Fougerolles, Noubar B. Afeyan
  • COMPOSITIONS AND METHODS FOR TOLERIZING CELLULAR SYSTEMS
    Publication number: 20160243221
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of molecules for tolerizing cellular systems.
    Type: Application
    Filed: October 17, 2014
    Publication date: August 25, 2016
    Applicant: Moderna Therapeutics, Inc.
    Inventors: Stephen G. Hoge, Eric Yi-Chun Huang
  • ALTERNATIVE NUCLEIC ACID MOLECULES CONTAINING REDUCED URACIL CONTENT AND USES THEREOF
    Publication number: 20160237134
    Abstract: The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them. In some aspects, the disclosure provides mRNA wherein the uracil content has been modified and which may be particularly effective for use in therapeutic compositions, because they may benefit from both high expression levels and limited induction of the innate immune response. In some aspects, the disclosure provides methods for the production of pharmaceutical compositions including mRNA without reverse phase chromatography.
    Type: Application
    Filed: December 4, 2015
    Publication date: August 18, 2016
    Inventors: Stephen G. HOGE, William Joseph ISSA, Ed MIRACCO, Jennifer NELSON, John REYNDERS, Matthew STANTON
  • CIRCULAR POLYNUCLEOTIDES
    Publication number: 20160194368
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of circular polynucleotides.
    Type: Application
    Filed: September 3, 2014
    Publication date: July 7, 2016
    Applicant: Moderna Therapeutics, Inc.
    Inventors: Stephen G. HOGE, Antonin DE FOUGEROLLES
  • CHIMERIC POLYNUCLEOTIDES
    Publication number: 20160194625
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of chimeric polynucleotide molecules.
    Type: Application
    Filed: September 3, 2014
    Publication date: July 7, 2016
    Inventors: Stephen G. HOGE, Andrew W. FRALEY, Divakar RAMAKRISHNAN
  • Compositions and Methods of Altering Cholesterol Levels
    Publication number: 20160136236
    Abstract: The present invention relates to compositions, methods and kits using polynucleotides, primary transcripts and mmRNA molecules. The present invention also relates to compositions and methods for altering cholesterol levels using polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: March 14, 2014
    Publication date: May 19, 2016
    Applicant: Moderna Therapeutics, Inc.
    Inventors: Stephen G. HOGE, Eric Yi-Chun HUANG, Joseph Beene BOLEN, Justin GUILD, Antonin DE FOUGEROLLES, Jeff Lynn ELLSWORTH
  • FORMULATION AND DELIVERY OF MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS
    Publication number: 20160038612
    Abstract: The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 11, 2016
    Inventors: Stephen G. Hoge, Öm Almarsson, David D. Hile, Ciarán Lawlor, John Podobinski, Staci Sabnis, Antonin de Fougerolles, Divakar Ramakrishnan, Kristy M. Wood
  • LONG-LIVED POLYNUCLEOTIDE MOLECULES
    Publication number: 20160024181
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of long-lived polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: March 13, 2014
    Publication date: January 28, 2016
    Inventors: Stephen G. Hoge, Eric Yi-Chun Huang, Tirtha Chakraborty, Sayda M. Elbashir
  • Compositions and methods of altering cholesterol levels
    Patent number: 8980864
    Abstract: The present invention relates to compositions, methods and kits using polynucleotides, primary transcripts and mmRNA molecules.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: March 17, 2015
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Stephen G. Hoge, Antonin de Fougerolles, Jeff Lynn Ellsworth
  • COMPOSITIONS AND METHODS OF ALTERING CHOLESTEROL LEVELS
    Publication number: 20150005372
    Abstract: The present invention relates to compositions, methods and kits using polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: August 8, 2014
    Publication date: January 1, 2015
    Inventors: Stephen G. Hoge, Antonin de Fougerolles, Jeff Lynn Ellsworth
  • COMPOSITIONS AND METHODS OF ALTERING CHOLESTEROL LEVELS
    Publication number: 20140275227
    Abstract: The present invention relates to compositions, methods and kits using polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: December 20, 2013
    Publication date: September 18, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Stephen G. Hoge, Antonin de Fougerolles, Jeff Lynn Ellsworth