Patents by Inventor Stephen G. Machatha

Stephen G. Machatha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Formulations containing clopidogrel and sulfoalkyl ether cyclodextrin and methods of use
    Patent number: 8853236
    Abstract: The present invention provides compositions containing clopidogrel, present as a free base or a pharmaceutically acceptable salt thereof, and sulfoalkyl ether cyclodextrin (SAE-CD). The compositions can be liquid, suspension or solid compositions. They can be adapted for oral, peroral or parenteral administration. The SAE-CD serves to aid in dissolution and stabilization of the clopidogrel in aqueous media. The stability of clopidogrel against hydrolytic degradation, thermal degradation, and photolytic degradation are improved. SAE-CD provides improved results over other cyclodextrin derivatives. The SAE-CD-containing composition of clopidogrel can be provided in liquid form, solid form or as a reconstitutable powder. Both ready-to-use and concentrated liquid compositions can be prepared. The liquid composition is optionally available as a clear solution.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: October 7, 2014
    Assignee: Cydex Pharmaceuticals, Inc.
    Inventors: Gerold L. Mosher, Rebecca L. Wedel, Karen T. Johnson, Stephen G. Machatha, Jane A. Cowee, Daniel J. Cushing
  • Pharmaceutical compositions comprising prasugrel and cyclodextrin derivatives and methods of making and using the same
    Patent number: 8835407
    Abstract: The present invention is directed to pharmaceutical compositions comprising prasugrel and a cyclodextrin derivative, and methods of making and using the same.
    Type: Grant
    Filed: July 5, 2012
    Date of Patent: September 16, 2014
    Assignee: CyDex Pharmaceuticals, Inc.
    Inventors: Gerold L. Mosher, Stephen G. Machatha, Daniel J. Cushing
  • Injectable Melphalan Compositions Comprising a Cyclodextrin Derivative and Methods of Making and Using the Same
    Publication number: 20140221488
    Abstract: The present invention is directed to pharmaceutical compositions comprising melphalan and a cyclodextrin derivative, and methods of making and using the same.
    Type: Application
    Filed: December 16, 2013
    Publication date: August 7, 2014
    Applicant: CYDEX PHARMACEUTICALS, INC.
    Inventors: James D. Pipkin, Stephen G. Machatha
  • Injectable Nitrogen Mustard Compositions Comprising a Cyclodextrin Derivative and Methods of Making and Using the Same
    Publication number: 20140213650
    Abstract: The present disclosure is directed to pharmaceutical compositions comprising a nitrogen mustard and a cyclodextrin derivative, and methods of making and using the same.
    Type: Application
    Filed: March 28, 2014
    Publication date: July 31, 2014
    Applicant: CYDEX PHARMACEUTICALS, INC.
    Inventors: James D. Pipkin, Stephen G. Machatha
  • Pharmaceutical Compositions Comprising Prasugrel and Cyclodextrin Derivatives and Methods of Making and Using the Same
    Publication number: 20130012534
    Abstract: The present invention is directed to pharmaceutical compositions comprising prasugrel and a cyclodextrin derivative, and methods of making and using the same.
    Type: Application
    Filed: July 5, 2012
    Publication date: January 10, 2013
    Inventors: Gerold L. MOSHER, Stephen G. Machatha, Daniel J. Cushing
  • Formulations containing clopidogrel and sulfoalkyl ether cyclodextrin and methods of use
    Patent number: 8343995
    Abstract: The present invention provides compositions containing clopidogrel, present as a free base or a pharmaceutically acceptable salt thereof, and sulfoalkyl ether cyclodextrin (SAE-CD). The compositions can be liquid, suspension or solid compositions. They can be adapted for oral, peroral or parenteral administration. The SAE-CD serves to aid in dissolution and stabilization of the clopidogrel in aqueous media. The stability of clopidogrel against hydrolytic degradation, thermal degradation, and photolytic degradation are improved. SAE-CD provides improved results over other cyclodextrin derivatives. The SAE-CD-containing composition of clopidogrel can be provided in liquid form, solid form or as a reconstitutable powder. Both ready-to-use and concentrated liquid compositions can be prepared. The liquid composition is optionally available as a clear solution.
    Type: Grant
    Filed: April 26, 2008
    Date of Patent: January 1, 2013
    Assignee: Cydex Pharmaceuticals, Inc.
    Inventors: Gerold L. Mosher, Rebecca L. Wedel, Karen T. Johnson, Stephen G. Machatha, Jane A. Cowee, Daniel J. Cushing
  • Pharmaceutical compositions comprising prasugrel and cyclodextrin derivatives and methods of making and using the same
    Patent number: 8236782
    Abstract: The present invention is directed to pharmaceutical compositions comprising prasugrel and a cyclodextrin derivative, and methods of making and using the same.
    Type: Grant
    Filed: May 13, 2010
    Date of Patent: August 7, 2012
    Assignee: Cydex Pharmaceuticals, Inc.
    Inventors: Gerold L. Mosher, Stephen G. Machatha, Daniel J. Cushing
  • Injectable Melphalan Compositions Comprising a Cyclodextrin Derivative and Methods of Making and Using the Same
    Publication number: 20100311838
    Abstract: The present invention is directed to pharmaceutical compositions comprising melphalan and a cyclodextrin derivative, and methods of making and using the same.
    Type: Application
    Filed: May 28, 2010
    Publication date: December 9, 2010
    Inventors: James D. PIPKIN, Stephen G. Machatha
  • Formulations Containing Clopidogrel and Sulfoalkyl Ether Cyclodextrin and Methods of Use
    Publication number: 20100292268
    Abstract: The present invention provides compositions containing clopidogrel, present as a free base or a pharmaceutically acceptable salt thereof, and sulfoalkyl ether cyclodextrin (SAE-CD). The compositions can be liquid, suspension or solid compositions. They can be adapted for oral, peroral or parenteral administration. The SAE-CD serves to aid in dissolution and stabilization of the clopidogrel in aqueous media. The stability of clopidogrel against hydrolytic degradation, thermal degradation, and photolytic degradation are improved. SAE-CD provides improved results over other cyclodextrin derivatives. The SAE-CD-containing composition of clopidogrel can be provided in liquid form, solid form or as a reconstitutable powder. Both ready-to-use and concentrated liquid compositions can be prepared. The liquid composition is optionally available as a clear solution.
    Type: Application
    Filed: April 26, 2008
    Publication date: November 18, 2010
    Applicant: CYDEX PHARMACEUTICALS, INC.
    Inventors: Jerry L. Mosher, Rebecca L. Wedel, Karen T. Johnson, Stephen G. Machatha, Jane A. Cowee, Daniel J. Cushing
  • Pharmaceutical Compositions Comprising Prasugrel and Cyclodextrin Derivatives and Methods of Making and Using the Same
    Publication number: 20100291056
    Abstract: The present invention is directed to pharmaceutical compositions comprising prasugrel and a cyclodextrin derivative, and methods of making and using the same.
    Type: Application
    Filed: May 13, 2010
    Publication date: November 18, 2010
    Inventors: Gerold L. Mosher, Stephen G. Machatha, Daniel J. Cushing