Abstract: Systems and methods for routing prescription drug claims between a pharmacy and a plurality of pharmacy benefit managers (PBMs). The systems and methods implemented by one or more processing circuits. One method includes receiving a prescription drug claim from the pharmacy, the prescription drug claim comprising routing information that causes the pharmacy to send the prescription drug claim to the prescription drug claim routing system. The method further includes obtaining a set of rules for routing the prescription drug claim. The method further includes selecting a PBM from the plurality of PBMs by applying the set of rules to the prescription drug claim. The method further includes modifying the routing information of the prescription drug claim to include updated routing information corresponding to the selected PBM and sending the prescription drug claim to the selected PBM for processing in accordance with the updated routing information.