Patents by Inventor Stephen Gardell

Stephen Gardell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof
    Patent number: 11806337
    Abstract: Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.
    Type: Grant
    Filed: July 27, 2022
    Date of Patent: November 7, 2023
    Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    Inventors: Stephen Gardell, Anthony B. Pinkerton, Eduard Sergienko, Hampton Sessions
  • SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF
    Publication number: 20230116770
    Abstract: Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.
    Type: Application
    Filed: July 27, 2022
    Publication date: April 13, 2023
    Inventors: Stephen GARDELL, Anthony B. PINKERTON, Eduard SERGIENKO, Hampton SESSIONS
  • Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof
    Patent number: 11452717
    Abstract: Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: September 27, 2022
    Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    Inventors: Stephen Gardell, Anthony B. Pinkerton, Eduard Sergienko, Hampton Sessions
  • SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF
    Publication number: 20210161873
    Abstract: Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.
    Type: Application
    Filed: January 9, 2018
    Publication date: June 3, 2021
    Inventors: Stephen GARDELL, Anthony B. PINKERTON, Eduard SERGIENKO, Hampton SESSIONS
  • Gamma secretase substrates and in vitro assays
    Publication number: 20060036077
    Abstract: The present invention features ?-secretase substrates and in vitro assays for measuring ?-secretase activity employing such substrates. The ?-secretase substrates described herein contain a hydrophilic polypeptide moiety covalently joined to the carboxyl terminus of a ?-CTF domain. A “?-CTF domain” is a polypeptide that can be cleaved by ?-secretase and which approximates the C-terminal fragment (amino acids 596-695) of APP produced after cleavage of APP by a ?-secretase, or is a functional derivative thereof.
    Type: Application
    Filed: October 5, 2005
    Publication date: February 16, 2006
    Inventors: Yueming Li, Min Xu, Qian Huang, Stephen Gardell
  • Gamma three protease
    Publication number: 20050065076
    Abstract: Gamma three protease is provided, a novel aspartyl class protease that is capable of taking part in the processing of amyloid precursor protein (APP) to A? peptide. Gamma three protease may be involved in the development and/or progression of Alzheimers disease. Methods of identifying inhibitors of gamma three protease, useful in the prevention or treatment of Alzheimers disease, are disclosed.
    Type: Application
    Filed: August 8, 2002
    Publication date: March 24, 2005
    Inventors: Ming-Chih Crouthamel, Stephen Gardell, Qian Huang, Ming-Tain Lai, Yueming Li