Patents by Inventor Stephen GRAVINA
Stephen GRAVINA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12016356Abstract: Newly identified fungal sweet-taste modifying proteins, and the cDNA encoding said proteins are described. Specifically, Myd proteins active in sweet taste activation, and the cDNA encoding the same, are described, along with methods for isolating such cDNA and for isolating and expressing such proteins. Also disclosed is use of a sweetening composition which includes the proteins of the invention, and methods to provide improved flavor to a product for oral administration.Type: GrantFiled: February 25, 2022Date of Patent: June 25, 2024Assignee: MYCOTECNOLOGY, INC.Inventors: Marina Nadal, Anthony J. Clark, Zheyuan Guo, Stephen A. Gravina, Anthony Westgate, Bassam Alkotaini, Ashley Han, Brendan Sharkey, Evan Strassburger, Joseph Meilen, Hyung Chang, Alan D. Hahn
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Publication number: 20240122220Abstract: Newly identified fungal sweet-taste modifying proteins, and the cDNA encoding said proteins are described. Specifically, Myd proteins active in sweet taste activation, and the cDNA encoding the same, are described, along with methods for isolating such cDNA and for isolating and expressing such proteins. Also disclosed is use of a sweetening composition which includes the proteins of the invention, and methods to provide improved flavor to a product for oral administration.Type: ApplicationFiled: November 13, 2023Publication date: April 18, 2024Applicant: MycoTechnology, Inc.Inventors: Marina NADAL, Anthony J. CLARK, Zheyuan GUO, Stephen A. GRAVINA, Anthony WESTGATE, Bassam ALKOTAINI, Ashley HAN, Brendan SHARKEY, Evan STRASSBURGER, Joseph MEILEN, Hyung CHANG, Alan D. HAHN
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Publication number: 20230210154Abstract: Newly identified fungal sweet-taste modifying proteins (designated Honey Truffle Sweetener (HTS)), and polynucleotides encoding the proteins are described. Specifically, Myd proteins with sweet taste modulation activity, and the cDNA encoding the same, are described, along with methods for isolating such cDNA and for isolating and expressing such proteins. Also disclosed are sweetening composition which includes the proteins of the invention, and methods to provide improved flavor to a product for oral administration.Type: ApplicationFiled: December 27, 2022Publication date: July 6, 2023Inventors: Marina NADAL, Anthony J. CLARK, Zheyuan GUO, Stephen A. GRAVINA, Anthony WESTGATE, Bassam ALKOTAINI, Ashley HAN, Brendan SHARKEY, Evan STRASSBURGER, Joseph MEILEN, James Patrick LANGAN
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Publication number: 20220183333Abstract: Newly identified fungal sweet-taste modifying proteins, and the cDNA encoding said proteins are described. Specifically, Myd proteins active in sweet taste activation, and the cDNA encoding the same, are described, along with methods for isolating such cDNA and for isolating and expressing such proteins. Also disclosed is use of a sweetening composition which includes the proteins of the invention, and methods to provide improved flavor to a product for oral administration.Type: ApplicationFiled: February 25, 2022Publication date: June 16, 2022Applicant: MycoTechnology, Inc.Inventors: Marina NADAL, Anthony J. CLARK, Zheyuan GUO, Stephen A. GRAVINA, Anthony WESTGATE, Bassam ALKOTAINI, Ashley HAN, Brendan SHARKEY, Evan STRASSBURGER, Joseph MEILEN, Hyung CHANG
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Patent number: 11297861Abstract: Newly identified fungal sweet-taste modifying proteins, and the cDNA encoding said proteins are described. Specifically, Myd proteins active in sweet taste activation, and the cDNA encoding the same, are described, along with methods for isolating such cDNA and for isolating and expressing such proteins. Also disclosed is use of a sweetening composition which includes the proteins of the invention, and methods to provide improved flavor to a product for oral administration.Type: GrantFiled: June 25, 2021Date of Patent: April 12, 2022Assignee: MycoTechnology, Inc.Inventors: Marina Nadal, Anthony J. Clark, Zheyuan Guo, Stephen A. Gravina, Anthony Westgate, Bassam Alkotaini, Ashley Han, Brendan Sharkey, Evan Strassburger, Joseph Meilen, Hyung Chang
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Patent number: 11259536Abstract: Processing of milk raw material produces a dairy salt. Preliminary treatment of the milk raw is carried out, with pasteurization and its concentration by nanofiltration through a filter with a pore size of 0.001-0.01 ?m, subsequent filtration of the obtained nanofiltration permeate through a membrane module with a pore size of 0.0001-0.001 ?m of a reverse osmosis unit, electrodialysis of the obtained RO retentate, concentration of the concentrate or its concentration and drying. The dairy salts may be manufactured and used to salt food products, beverages, granulated cottage cheese, potato chips, crackers, and dips. A masking fraction with organic acid, amino acid, fatty acid, and sugar portions successfully hides the off-notes otherwise associated with potassium compositions. Food products salted with any of the dairy salts described herein achieve reduced sodium content without compromising flavor.Type: GrantFiled: July 8, 2020Date of Patent: March 1, 2022Assignee: Wimm-Bill-Dann OJSCInventors: Grigoriy A. Dudarev, Stephen Gravina, Sivaraj Kaliappan, Sergey N. Knyazev, Yuliya Kurash, Maksim N. Omarov, Sergey I. Perminov, Vitaliy S. Somov, James William Stalder
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Publication number: 20210401013Abstract: Newly identified fungal sweet-taste modifying proteins, and the cDNA encoding said proteins are described. Specifically, Myd proteins active in sweet taste activation, and the cDNA encoding the same, are described, along with methods for isolating such cDNA and for isolating and expressing such proteins. Also disclosed is use of a sweetening composition which includes the proteins of the invention, and methods to provide improved flavor to a product for oral administration.Type: ApplicationFiled: June 25, 2021Publication date: December 30, 2021Inventors: Marina NADAL, Anthony J. CLARK, Zheyuan GUO, Stephen A. GRAVINA, Anthony WESTGATE, Bassam ALKOTAINI, Ashley HAN, Brendan SHARKEY, Evan STRASSBURGER, Joseph Meilen, Hyung Chang
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Patent number: 10966447Abstract: The present disclosure provides novel sweetener compositions comprising a compound having a structure according to Formula I: wherein R1, R2, R3, and R4 are described herein. Also provided are methods of modulating sweetness profile of a product by adding a compound of Formula I to the product, such as a beverage product or a food product. For example, the compound described herein can be added to increase the overall sweetness of a nutritive sweetener sweetened beverages; decrease the sweetness time-of-onset for high potency sweeteners such as rebaudioside A; decreasing bitter, metallic and licorice off-notes of high potency sweeteners; and improve the sweet quality of sweetened products.Type: GrantFiled: July 19, 2016Date of Patent: April 6, 2021Assignee: PepsiCo, Inc.Inventors: Shawn Erickson, Yu-Wen Feng, Christophe Galopin, Stephen Gravina, Yuliya Kurash, Thomas Lee, Laura Nattress, Ting Wang
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Publication number: 20200337325Abstract: Processing of milk raw material produces a dairy salt. Preliminary treatment of the milk raw is carried out, with pasteurization and its concentration by nanofiltration through a filter with a pore size of 0.001-0.01 ?m, subsequent filtration of the obtained nanofiltration permeate through a membrane module with a pore size of 0.0001-0.001 ?m of a reverse osmosis unit, electrodialysis of the obtained RO retentate, concentration of the concentrate or its concentration and drying. The dairy salts may be manufactured and used to salt food products, beverages, granulated cottage cheese, potato chips, crackers, and dips. A masking fraction with organic acid, amino acid, fatty acid, and sugar portions successfully hides the off-notes otherwise associated with potassium compositions. Food products salted with any of the dairy salts described herein achieve reduced sodium content without compromising flavor.Type: ApplicationFiled: July 8, 2020Publication date: October 29, 2020Inventors: Grigoriy A. DUDAREV, Stephen GRAVINA, Sivaraj KALIAPPAN, Sergey N. KNYAZEV, Yuliya KURASH, Maksim N. OMAROV, Sergey I. PERMINOV, Vitaliy S. SOMOV, James William STALDER
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Patent number: 10107794Abstract: Co-expression of T1R2 and T1R3 results in a taste receptor that responds to sweet taste stimuli, including naturally occurring and artificial sweeteners. Cells such as U2-OS, which express a functional sweet receptor, can be used in cell-based assays to detect cellular responses to tastants.Type: GrantFiled: May 9, 2014Date of Patent: October 23, 2018Assignee: PepsiCo, Inc.Inventors: Yuliya Kurash, Stephen Gravina
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Publication number: 20180020708Abstract: The present disclosure provides novel sweetener compositions comprising a compound having a structure according to Formula I: wherein R1, R2, R3, and R4 are described herein. Also provided are methods of modulating sweetness profile of a product by adding a compound of Formula I to the product, such as a beverage product or a food product. For example, the compound described herein can be added to increase the overall sweetness of a nutritive sweetener sweetened beverages; decrease the sweetness time-of-onset for high potency sweeteners such as rebaudioside A; decreasing bitter, metallic and licorice off-notes of high potency sweeteners; and improve the sweet quality of sweetened products.Type: ApplicationFiled: July 19, 2016Publication date: January 25, 2018Inventors: Shawn Erickson, Yu-Wen FENG, Christophe GALOPIN, Stephen GRAVINA, Yuliya KURASH, Thomas LEE, Laura NATTRESS, Ting WANG
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Patent number: 9766236Abstract: This disclosure provides a taste receptor internalization assay useful for identifying taste modulators.Type: GrantFiled: May 9, 2014Date of Patent: September 19, 2017Assignee: PEPSICO, INC.Inventors: Yuliya Kurash, Stephen Gravina
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Publication number: 20160324175Abstract: Processing of milk raw material produces a dairy salt. Preliminary treatment of the milk raw is carried out, with pasteurization and its concentration by nanofiltration through a filter with a pore size of 0.001-0.01 ?m, subsequent filtration of the obtained nanofiltration permeate through a membrane module with a pore size of 0.0001-0.001 ?m of a reverse osmosis unit, electrodialysis of the obtained RO retentate, concentration of the concentrate or its concentration and drying. The dairy salts may be manufactured and used to salt food products, beverages, granulated cottage cheese, potato chips, crackers, and dips. A masking fraction with organic acid, amino acid, fatty acid, and sugar portions successfully hides the off-notes otherwise associated with potassium compositions. Food products salted with any of the dairy salts described herein achieve reduced sodium content without compromising flavor.Type: ApplicationFiled: December 1, 2014Publication date: November 10, 2016Inventors: Grigoriy A. DUDAREV, Stephen GRAVINA, Sivaraj KALIAPPAN, Sergey N. KNYAZEV, Yuliya KURASH, Maksim N. OMAROV, Sergey I. PERMINOV, Vitaliy S. SOMOV, James William STALDER
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Publication number: 20160316799Abstract: A beverage comprising water, at least one non-nutritive sweetener having a bitter off-note taste, linoleic acid, and heptanoic acid. A beverage comprising water, at least one non-nutritive sweetener, a combination of caprylic acid, caproic acid, and butyric acid, and at least one aldehyde selected from the group consisting of decanal, nonanal, and 2-methyl-butyraldehyde.Type: ApplicationFiled: December 8, 2014Publication date: November 3, 2016Inventors: Anthony AGLIONE, Kelly J. CASSUTT, Sofya DRAGAN, Stephen GRAVINA, Yuliya KURASH, Winsome JOHNSON
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Publication number: 20160091488Abstract: Co-expression of T1R2 and T1R3 results in a taste receptor that responds to sweet taste stimuli, including naturally occurring and artificial sweeteners. Cells such as U2-OS, which express a functional sweet receptor, can be used in cell-based assays to detect cellular responses to tastants.Type: ApplicationFiled: May 9, 2014Publication date: March 31, 2016Inventors: Yuliya KURASH, Stephen GRAVINA
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Publication number: 20160084834Abstract: This disclosure provides a taste receptor internalization assay useful for identifying taste modulators.Type: ApplicationFiled: May 9, 2014Publication date: March 24, 2016Inventors: Yuliya KURASH, Stephen GRAVINA