Patents by Inventor Stephen Gwaltney

Stephen Gwaltney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HISTONE DEMETHYLASE INHIBITORS
    Publication number: 20190256509
    Abstract: This disclosure relates, inter alia, to compounds that inhibit histone demethylase activity. In particular, the disclosure relates to compounds that inhibit histone lysine demethylase KDM5B, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions disclosed herein.
    Type: Application
    Filed: June 8, 2017
    Publication date: August 22, 2019
    Inventor: Stephen GWALTNEY
  • HISTONE DEMETHYLASE INHIBITORS
    Publication number: 20190055212
    Abstract: This disclosure relates to compounds that inhibit histone demethylase activity. In particular, the disclosure relates to compounds that inhibit histone lysine demethylase KDM5B, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions disclosed herein.
    Type: Application
    Filed: February 16, 2017
    Publication date: February 21, 2019
    Inventor: Stephen Gwaltney
  • DIPEPTIDYL PEPTIDASE INHIBITORS
    Publication number: 20080108808
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C?NR9; and each L, X, R1, R2, and R3 are as defined herein.
    Type: Application
    Filed: October 30, 2007
    Publication date: May 8, 2008
    Inventors: Jun Feng, Stephen Gwaltney, Jeffrey Stafford, Zhiyuan Zhang, Bruce Elder, Paul Isbester, Grant Palmer, Jonathon Salsbury, Luckner Ulysse
  • DIPEPTIDYL PEPTIDASE INHIBITORS
    Publication number: 20080108807
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C?NR9; and each L, X, R1, R2, and R3 are as defined herein.
    Type: Application
    Filed: October 30, 2007
    Publication date: May 8, 2008
    Inventors: Jun Feng, Stephen Gwaltney, Jeffrey Stafford, Zhiyuan Zhang, Bruce Elder, Paul Isbester, Grant Palmer, Jonathon Salsbury, Luckner Ulysse
  • DIPEPTIDYL PEPTIDASE INHIBITORS
    Publication number: 20080003283
    Abstract: Compounds are provided for use with DPP-IV of the formula: Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Application
    Filed: August 7, 2007
    Publication date: January 3, 2008
    Applicant: TAKEDA PHARMACEUTICAL COMPANY, INC.
    Inventors: Jun Feng, Stephen Gwaltney, Jeffrey Stafford, Zhiyuan Zhang, Bruce Elder, Paul Isbester, Grant Palmer, Jonathan Salsbury, Luckner Ulysse
  • GLUCOKINASE ACTIVATORS
    Publication number: 20070281942
    Abstract: Compounds are provided for use with hexokinases that comprise: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Application
    Filed: May 25, 2007
    Publication date: December 6, 2007
    Inventors: Sheldon Cao, Jun Feng, Stephen Gwaltney, David Hosfield, Robert Skene, Jeffrey Stafford, Mingnam Tang
  • DIPEPTIDYL PEPTIDASE INHIBITORS
    Publication number: 20070249611
    Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound of the formula: wherein the substituents are as defined herein.
    Type: Application
    Filed: March 27, 2007
    Publication date: October 25, 2007
    Inventors: Jun Feng, Stephen Gwaltney, Michael Wallace, Zhiyuan Zhang
  • GLUCOKINASE ACTIVATORS
    Publication number: 20070244169
    Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.
    Type: Application
    Filed: December 19, 2006
    Publication date: October 18, 2007
    Inventors: Jun Feng, Stephen Gwaltney, David Hosfield, Shigekazu Sasaki, Robert Skene, Michael Wallace
  • GLUCOKINASE ACTIVATORS
    Publication number: 20070213349
    Abstract: Compounds are provided for use with glucokinase that comprise the formula: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Application
    Filed: March 8, 2007
    Publication date: September 13, 2007
    Inventors: Zacharia Cheruvallath, Jun Feng, Prasuna Guntupalli, Stephen Gwaltney, Stephen Kaldor, Joanne Miura, Mark Sabat, Mingnam Tang, Beverly Wolgast
  • GLUCOKINASE ACTIVATORS
    Publication number: 20070197532
    Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.
    Type: Application
    Filed: November 17, 2006
    Publication date: August 23, 2007
    Inventors: Sheldon Cao, Jun Feng, Yasuhiro Imaeda, Stephen Gwaltney, David Hosfield, Nobuyuki Takakura, Mingnam Tang
  • Farnesyltransferase Inhibitors
    Publication number: 20060264476
    Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
    Type: Application
    Filed: July 25, 2006
    Publication date: November 23, 2006
    Inventors: Akiyo Claiborne, Stephen Gwaltney, Lisa Hasvold, Qun Li, Tongmei Li, Nan-Horng Lin, Robert Mantei, Todd Rockway, Hing Sham, Gerard Sullivan, Yunsong Tong, Gary Wang, Le Wang, Xilu Wang, Wei-Bo Wang
  • Dipeptidyl peptidase inhibitors
    Publication number: 20060135767
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a member selected from the group consisting of: wherein E is CH or N, Q is selected from the group consisting of CO, CS, SO, SO2, or C?NR4, and L, X, Z, R2 and R3 are as defined herein.
    Type: Application
    Filed: December 16, 2005
    Publication date: June 22, 2006
    Inventors: Jun Feng, Stephen Gwaltney, Jeffrey Stafford, Michael Wallace, Zhiyuan Zhang
  • Dipeptidyl peptidase inhibitors
    Publication number: 20060014764
    Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound of the formula: wherein R2 is amino (C1-6)alkyl, hetero(C3-12)cycloakyl, hetero(C4-12)bicycloaryl, heteroaryl, or cyano; and W, X, Y, Z, R1, R5 and R7 are as defined herein.
    Type: Application
    Filed: July 15, 2005
    Publication date: January 19, 2006
    Inventors: Jun Feng, Stephen Gwaltney, Betty Lam, Zhiyuan Zhang
  • Dipeptidyl peptidase inhibitors
    Publication number: 20050272765
    Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound of the formula: wherein the substituents are as defined herein.
    Type: Application
    Filed: June 3, 2005
    Publication date: December 8, 2005
    Inventors: Jun Feng, Stephen Gwaltney, Michael Wallace, Zhiyuan Zhang
  • Dipeptidyl peptidase inhibitors
    Publication number: 20050261271
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C?NR9; and each L, X, R1, R2, and R3 are as defined herein.
    Type: Application
    Filed: March 15, 2005
    Publication date: November 24, 2005
    Inventors: Jun Feng, Stephen Gwaltney, Jeffrey Stafford, Zhiyuan Zhang, Bruce Elder, Paul Isbester, Grant Palmer, Jonathon Salsbury, Luckner Ulysse
  • Cell proliferation inhibitors
    Publication number: 20050187246
    Abstract: Compounds having formula (I) inhibit cellular proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.
    Type: Application
    Filed: April 19, 2005
    Publication date: August 25, 2005
    Inventors: Qun Li, Hing Sham, Keith Woods, Beth Steiner, Stephen Gwaltney, Kenneth Barr, Hovis Imade, Saul Rosenberg
  • Dipeptidyl peptidase inhibitors
    Publication number: 20050075330
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
    Type: Application
    Filed: August 12, 2004
    Publication date: April 7, 2005
    Inventors: Jun Feng, Stephen Gwaltney, Stephen Kaldor, Jeffrey Stafford, Michael Wallace, Zhiyuan Zhang
  • Dipeptidyl peptidase inhibitors
    Publication number: 20050070706
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
    Type: Application
    Filed: August 12, 2004
    Publication date: March 31, 2005
    Inventors: Jun Feng, Stephen Gwaltney, Stephen Kaldor, Jeffrey Stafford, Michael Wallace, Zhiyuan Zhang
  • Dipeptidyl peptidase inhibitors
    Publication number: 20050070535
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
    Type: Application
    Filed: August 12, 2004
    Publication date: March 31, 2005
    Inventors: Jun Feng, Stephen Gwaltney, Stephen Kaldor, Jeffrey Stafford, Michael Wallace, Zhiyuan Zhang
  • Dipeptidyl peptidase inhibitors
    Publication number: 20050070530
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
    Type: Application
    Filed: August 12, 2004
    Publication date: March 31, 2005
    Inventors: Jun Feng, Stephen Gwaltney, Stephen Kaldor, Jeffrey Stafford, Michael Wallace, Zhiyuan Zhang