Patents by Inventor Stephen H. Benedict

Stephen H. Benedict has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of regulatory T cells using ICAM-1 co-stimulation
    Patent number: 8323969
    Abstract: A method for generating a purified regulatory T cell composition having a CD4+CD25+Foxp3? phenotype from naive T cells having CD4+CD45RA+RO?CD11alo CD27+ phenotype comprising the steps of stimulating a T cell receptor on the naive T cells and stimulating ICAM-1 on the naive T cells.
    Type: Grant
    Filed: May 16, 2008
    Date of Patent: December 4, 2012
    Assignee: University of Kansas
    Inventors: Stephen H. Benedict, Kelli M. Cool, Abby L. Dotson
  • PREPARATION OF REGULATORY T CELLS USING ICAM-1 CO-STIMULATION
    Publication number: 20080286245
    Abstract: A method for generating a purified regulatory T cell composition having a CD4+CD25+Foxp3? phenotype from naive T cells having CD4+CD45RA+RO?CD11alo CD27+ phenotype comprising the steps of stimulating a T cell receptor on the naive T cells and stimulating ICAM-1 on the naive T cells.
    Type: Application
    Filed: May 16, 2008
    Publication date: November 20, 2008
    Applicant: UNIVERSITY OF KANSAS
    Inventors: Stephen H. Benedict, Kelli M. Cool, Abby L. Dotson
  • Peptide Compositions which induce immune tolerance and methods of use
    Patent number: 6653282
    Abstract: Peptide compositions which inhibit the binding of one protein to another protein, and corresponding methods of use are disclosed. These peptide compositions include at least one peptide which binds to one protein, and at least one peptide which binds to the other protein. In the preferred embodiment, the peptide composition is composed of a combination of cyclic ICAM-1-based and LFA-1-based peptides which inhibit the binding of LFA-1 to ICAM-1. Such LFA-1/ICAM-1-based peptide compositions can be used to treat disease states such as rejection of transplanted organs, allergies, and autoimmune diseases.
    Type: Grant
    Filed: January 5, 2000
    Date of Patent: November 25, 2003
    Inventors: Stephen H. Benedict, Teruna J. Siaiiann, Marcia A. Chan, Scott A. Tibbetts