Patents by Inventor Stephen H. Monroe
Stephen H. Monroe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140135284Abstract: This invention relates to a buffering composition for the topical or internal treatment of animal tissues to buffer and normalize the pH of the cellular environment while also affecting specific cellular membrane ion channels as a method to affect inflammation, proteases, reactive oxygen species and free radicals, the composition containing a pharmaceutically-effective concentration of an acid and its base salt, where the counterions of the base salt are potassium and at least one of cesium and rubidium, or all three.Type: ApplicationFiled: November 6, 2013Publication date: May 15, 2014Inventor: Stephen H. MONROE
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Publication number: 20110218618Abstract: A method for bulk manufacture of a microporous sheet material from polyolefin fibers, where an average pore size in the material is controlled by calendering the material through low-energy rollers at a suitable temperature, pressure and speed. The material is useful to selectively pass or reject certain substances, and may be combined in a resilient, tube-shaped configuration to form a self-regenerating drug-delivering vascular stent that reduces inflammation at the stent site to prevent restenosis.Type: ApplicationFiled: March 3, 2011Publication date: September 8, 2011Inventor: Stephen H. Monroe
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Publication number: 20100260863Abstract: This invention relates to a composition for the topical or internal treatment of animal tissues to buffer and normalize the pH of the cellular environment while also effecting specific cellular membrane ion channels as a method to affect inflammation, proteases, reactive oxygen species and free radicals.Type: ApplicationFiled: December 11, 2008Publication date: October 14, 2010Inventor: Stephen H. Monroe
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Publication number: 20100196507Abstract: A synthesized composition containing zinc ions, calcium ions, rubidium ions and/or potassium ions in a pharmaceutically acceptable carrier, which, when applied to an open wound, effectively modulates the activity of at least MMP-2 and/or MMP-9 in the wound. A method for treatment of wounds is disclosed.Type: ApplicationFiled: September 23, 2009Publication date: August 5, 2010Applicant: GREYSTONE MEDICAL GROUP, INC.Inventors: Stephen H. MONROE, Matthias Johannes HOEKSTRA
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Publication number: 20080220091Abstract: Reactive oxygen species associated with a wound are modulated through treatment of the wound with a solution of metal ions selected from the group consisting of potassium ions, zinc ions, calcium ions and rubidium ions, at a pH of between about 5 and about 7. Preferably, citric acid is employed to adjust the pH of the solution. Application of the extract to a wound exhibiting superoxide anions has been found to be effective in the treatment of these wounds through the reduction of the level of superoxide anions. Moreover, treatment of partial thickness excision wounds as well as contact burn wounds with the present composition has been found to improve epithelialization of these wounds. In addition to the antioxidant activity of the present invention, treatment of the wound employing the present composition produces inhibitory effects on ROS production by human PMNs and on human complement activation, and therefore, is further beneficial in chronic wound management.Type: ApplicationFiled: January 7, 2008Publication date: September 11, 2008Inventors: Stephen H. Monroe, Matthias Johannes Hoekstra, Albertus Justus Johannes Van Den Berg
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Publication number: 20040170703Abstract: Reactive oxygen species associated with a wound are modulated through treatment of the wound with a solution of metal ions selected from the group consisting of potassium ions, zinc ions, calcium ions and rubidium ions, at a pH of between about 5 and about 7. Preferably, citric acid is employed to adjust the pH of the solution. Application of the extract to a wound exhibiting superoxide anions has been found to be effective in the treatment of these wounds through the reduction of the level of superoxide anions. Moreover, treatment of partial thickness excision wounds as well as contact burn wounds with the present composition has been found to improve epithelialization of these wounds. In addition to the antioxidant activity of the present invention, treatment of the wound employing the present composition produces inhibitory effects on ROS production by human PMNs and on human complement activation, and therefore, is further beneficial in chronic wound management.Type: ApplicationFiled: December 23, 2003Publication date: September 2, 2004Applicant: Greystone Medical Group, Inc.Inventors: Hans Hoekstra, Stephen H. Monroe, A. J. J. Van Den Berg
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Publication number: 20040105897Abstract: A synthesized composition containing one or more of zinc ions, calcium ions, rubidium ions and/or potassium ions in a pharmaceutically acceptable carrier, which, when administered to a patient in need thereof, effectively modulates the activity of at least MMP-2 and/or MMP-9 in the wound. A method is disclosed.Type: ApplicationFiled: August 21, 2003Publication date: June 3, 2004Applicant: Greystone Medical Group, Inc.Inventors: Stephen H. Monroe, Hans Hoekstra
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Publication number: 20040023937Abstract: Composition for halting the metastasis of cancer cells comprising rubidum ursolate. The rubidium ursolate is formed from a mixture of rubidium and ursolic acid obtained from the bark of the Virburnum plant.Type: ApplicationFiled: May 22, 2003Publication date: February 5, 2004Applicant: Greystone Medical Group, Inc.Inventor: Stephen H. Monroe
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Publication number: 20030133991Abstract: A synthesized composition containing zinc ions, calcium ions, rubidium ions and/or potassium ions in a pharmaceutically acceptable carrier, which, when applied to an open wound, effectively modulates the activity of at least MMP-2 and/or MMP-9 in the wound. A method for treatment of wounds is disclosed.Type: ApplicationFiled: November 27, 2002Publication date: July 17, 2003Applicant: Greystone Medical Group, Inc.Inventors: Stephen H. Monroe, Hans Hoekstra
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Patent number: 6171443Abstract: A high-opacity cellulose-free synthetic paper is formed from a wet-laid nonwoven web of thermoplastic fibers, all or most of which fibers are made of a predetermined polymeric material. The wet-laid web is dried to remove excess water, drying being carried cut at temperatures below the melting temperature of the predetermined polymeric material. The dried nonwoven web is saturated on at least one side with a pigmented binder forming a continuous coating thereon. The binder is cured at temperatures below the melting temperature of the predetermined polymeric material.Type: GrantFiled: June 6, 1995Date of Patent: January 9, 2001Assignee: Polyweave International, LLCInventors: James A. Goettmann, Peter J. Angelini, Stephen H. Monroe, John R. Boylan
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Patent number: 5853541Abstract: A degradable agricultural mulch, mat or ground cover including cotton linters fibers, hardwood kraft pulp fibers, softwood kraft pulp fibers, and a water holdout material which is strong enough to be laid mechanically and is 100% photo- or biodegradable.Type: GrantFiled: June 28, 1996Date of Patent: December 29, 1998Assignee: International Paper CompanyInventors: Stephen H. Monroe, James A. Goettmann, Gerald A. Funk
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Patent number: 5800884Abstract: A gloss coating composition comprising radiation curable oligomers and monomers, and photosensitizers in a homogeneous mixture having a viscosity in the range of 4500 to 8000 cps; wherein the presence of the photosensitizers causes polymerization of the radiation curable oligomers and monomers when exposed to an ultraviolet light source. The coating composition is applied to at least one surface of a substrate and exposed to an ultraviolet light source resulting in curing of the composition onto the substrate surface without substantial penetration into the substrate surface forming a gloss coated substrate.Type: GrantFiled: June 2, 1995Date of Patent: September 1, 1998Assignee: International Paper CompanyInventors: Guy D'Anna, Stephen H. Monroe, Peter J. Angelini, James A. Goettmann, John R. Boylan
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Patent number: 5616384Abstract: An in-mold label material is a nonwoven mat of fibers having one side fused with the outer surface of a polymeric container and the other side coated with a pigment-containing latex suitable for printing thereon. The label paper is manufactured from commercially available fibers combined in water into a homogeneous mixture and then formed into a mat employing a wet-lay process. For use with polyethylene containers, the label may be a web consisting of 88-100% polyethylene fibers and 0-15% polyvinyl alcohol fibers or 70-100% polyethylene fibers, 0-15% polyvinyl alcohol fibers and 0-30% polypropylene fibers. For use with polyester containers, the label may be a web consisting of 50-90% polyester staple fibers, 10-40% bicomponent polyester/co-polyester, core/sheath binder fibers and 0-10% polyvinyl alcohol binder fibers thermally bonded together. The nonwoven web of fibers has a pigmented coating.Type: GrantFiled: December 2, 1993Date of Patent: April 1, 1997Assignee: International Paper CompanyInventors: James A. Goettmann, Stephen H. Monroe, Peter J. Angelini, John R. Boylan
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Patent number: 5532298Abstract: A degradable agricultural ground cover which is composed of high density polyethylene polymer fiber and cellulose pulp which is 100% photo and biodegradable for use in weed control and moisture retention in soil. The unique agricultural mat or cover lasts 8-12 weeks before serious photo and biodegradability occurs, while allowing crop plants sufficient time to mature and produce. The sheet totally disappears with plowing and tilling, becoming a soil extender until complete degradation occurs.Type: GrantFiled: February 10, 1995Date of Patent: July 2, 1996Assignee: International PaperInventors: Stephen H. Monroe, James A. Goettmann, Gerald A. Funk
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Patent number: 5492733Abstract: A gloss coating composition comprising radiation curable oligomers and monomers, and photosensitizers in a homogeneous mixture having a viscosity in the range of 4500 to 8000 cps; wherein the presence of the photosensitizers causes polymerization of the radiation curable oligomers and monomers when exposed to an ultraviolet light source. The coating composition is applied to at least one surface of a substrate and exposed to an ultraviolet light source resulting in curing of the composition onto the substrate surface without substantial penetration into the substrate surface forming a gloss coated substrate.Type: GrantFiled: September 20, 1993Date of Patent: February 20, 1996Assignee: International Paper CompanyInventors: Guy D'Anna, Stephen H. Monroe, Peter J. Angelini, James A. Goettmann, John R. Boylan
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Patent number: 5064692Abstract: A method and apparatus for producing a paper product having a surface with enhanced gloss. The method includes the following steps: Applying a continuous layer of an impressionable coating material to a paper product; contacting the layer of coating material with a polymer release film having a smooth and glossy surface substantially free of defects, the surface having non-adhering and release characteristics; and solidifying the coating material during contact with the release film. Using this technique, a smooth and glossy surface of the release film is substantially imparted to a surface of the layer of solidified coating material. In the case of clay-coated substrates, the coating is solidified by heating, whereas in the case of polyethylene-coated substrates, the coating is solidified by cooling. The end product is a coated substrate in which the coating has a glossy surface to which the texture of a film has been imparted.Type: GrantFiled: February 15, 1990Date of Patent: November 12, 1991Assignee: International Paper CompanyInventors: Leroy C. Hofmann, Robert W. Hicks, Jasper H. Field, Stephen H. Monroe