Abstract: A system providing a haptic feedback improving its functionality includes a haptic feedback device and communicates with a catheter. In operation, the haptic feedback device forms a strap and each of the plurality of actuating regions is arranged along a circumference a of the haptic feedback device. Further, in operation spatial information is transmitted from at least one of a plurality of sensing locations to the haptic feedback device and in accordance with the transmitted spatial information at least one of the plurality of actuating regions is actuated to provide the haptic feedback.

Abstract: A method for translocating a cationic micro/nanoparticle across a mucus layer, the method including (a) contacting the mucus layer with at least one alginate oligomer, the alginate oligomer having at least 70% mannuronate residues, together with the cationic micro/nanoparticle; or (b)(i) contacting the cationic micro/nanoparticle with an alginate oligomer having at least 70% mannuronate residues thereby forming a micro/nanoparticle carrying the alginate oligomer, and (b)(ii) contacting the mucus layer with the micro/nanoparticle prepared in step (b)(i).

Abstract: A steerable catheter distal tip for performing sensor assisted navigation for a catheter assembly and a robotically assisted interventional device. The steerable catheter distal tip for performing sensor assisted navigation includes an ultrasonic transducer system arranged to surround a circumference of the catheter distal tip, wherein the ultrasonic transducer system is operable to generate distance signals indicative of distances between a plurality of sensing locations on the circumference of the catheter distal tip from walls of a cavity in which the catheter distal tip is located in operation; and a signal processing unit comprising a controller, which is operable to cause the catheter distal tip being steered along a defined navigation path based on the distance signals.

Abstract: An electrical power connector includes a connector housing having a slot at a mating end of the connector housing configured to receive a power distribution assembly. The electrical power connector includes power contacts received in the connector housing configured to be is coupled to a power distribution contact of the power distribution assembly. The electrical power connector includes a monitoring device having a monitoring circuit, a monitoring sensor coupled to the monitoring circuit, and a monitoring transmitter coupled to the monitoring circuit. The monitoring sensor is coupled to the power contact to monitor an operating characteristic of the power contact. The monitoring circuit receives sensor signals from the monitoring sensor and the monitoring transmitter transmits monitoring signals from the monitoring circuit based on the operating characteristic of the power contact to a monitoring network remote from the electrical power connector.

Abstract: A car floor for an elevator car includes a planar base part and installation feet arranged thereon. The installation feet support the car floor on the shaft floor of an elevator shaft during the elevator car installation phase. In order to orient the base part in a horizontal position, each of the installation feet is in the form of a height-adjustable installation foot. The height-adjustable installation foot has a threaded rod as part of a threaded spindle for height adjustment.

Abstract: An electrical power connector includes a connector housing having a slot at a mating end of the connector housing configured to receive a power distribution assembly. The electrical power connector includes power contacts received in the connector housing configured to be is coupled to a power distribution contact of the power distribution assembly. The electrical power connector includes a monitoring device having a monitoring circuit, a monitoring sensor coupled to the monitoring circuit, and a monitoring transmitter coupled to the monitoring circuit. The monitoring sensor is coupled to the power contact to monitor an operating characteristic of the power contact. The monitoring circuit receives sensor signals from the monitoring sensor and the monitoring transmitter transmits monitoring signals from the monitoring circuit based on the operating characteristic of the power contact to a monitoring network remote from the electrical power connector.

Abstract: A car floor for an elevator car includes a planar base part and installation feet arranged thereon. The installation feet support the car floor on the shaft floor of an elevator shaft during the elevator car installation phase. In order to orient the base part in a horizontal position, each of the installation feet is in the form of a height-adjustable installation foot. The height-adjustable installation foot has a threaded rod as part of a threaded spindle for height adjustment.

Abstract: A non-viral delivery complex comprising a cationic core which is a nanoparticle comprising a peptide having a polycationic nucleic acid binding component, a cleavable spacer element and a cell surface receptor binding component; a nucleic acid and optionally a cationic lipid; and an anionic liposomal coating surrounding the cationic core, said coating comprising lipids from a subject's cells. Also related formulations, uses and methods.

Abstract: A nanoparticle complex for delivery to cells comprising an RNA interference agent and a delivery vehicle comprised of a liposome and peptide. The peptide may be transmembrane, at least part of which is located external to the liposome. The delivery vehicle is used to deliver the RNA interference agent to cells. The RNA interference agent may target the activity of E3 ubiquitin ligase Itch. The complex may be used to treat chemotherapy resistant tumours and/or cancers. Also related compositions, combination, kit, methods and uses thereof.

Abstract: A non-viral delivery complex comprising a cationic core which is a nanoparticle comprising a peptide having a polycationic nucleic acid binding component, a cleavable spacer element and a cell surface receptor binding component; a nucleic acid and optionally a cationic lipid; and an anionic liposomal coating surrounding the cationic core, said coating comprising lipids from a subject's cells. Also related formulations, uses and methods.

Abstract: A method for translocating a cationic micro/nanoparticle across a mucus layer, the method including (a) contacting the mucus layer with at least one alginate oligomer, the alginate oligomer having at least 70% mannuronate residues, together with the cationic micro/nanoparticle; or (b)(i) contacting the cationic micro/nanoparticle with an alginate oligomer having at least 70% mannuronate residues thereby forming a micro/nanoparticle carrying the alginate oligomer, and (b)(ii) contacting the mucus layer with the micro/nanoparticle prepared in step (b)(i).

Abstract: A method of surface sealing a porous fibrous substrate is provided. According to the method, a porous fibrous substrate possessing a moisture content and a surface with pores is provided. A sealant composition is applied to a surface of the porous fibrous substrate and permitted to penetrate the surface pores of the porous fibrous substrate and undergo cure while participating in a foaming reaction with the moisture content to establish a water-resistant polymeric foam sealant impregnated into the porous fibrous substrate. The water-resistant polymeric foam sealant contains a polyurethane and/or polyurea.

Abstract: A method of surface sealing a porous fibrous substrate is provided. According to the method, a porous fibrous substrate possessing a moisture content and a surface with pores is provided. A sealant composition is applied to a surface of the porous fibrous substrate and permitted to penetrate the surface pores of the porous fibrous substrate and undergo cure while participating in a foaming reaction with the moisture content to establish a water-resistant polymeric foam sealant impregnated into the porous fibrous substrate. The water-resistant polymeric foam sealant contains a polyurethane and/or polyurea.

Abstract: An impact resistant door skin, a door including the same, and a method of manufacturing an impact resistant door skin from a pre-formed door skin are provided. The method includes the steps of providing at least one preformed door skin and applying adhesive to a rear side of the at least one preformed door skin. A fiberglass mesh mat is pressed onto the rear side of the at least one preformed door skin. Then, chopped glass fibers coated with adhesive are sprayed onto the rear side of the at least one preformed door skin using a chopper gun to form a layer of chopped glass fibers on the fiberglass mesh mat. The performed door skin may be a molded door skin having at least one recessed panel formed therein.

Abstract: A method of surface sealing a porous fibrous substrate is provided. According to the method, a porous fibrous substrate possessing a moisture content and a surface with pores is provided. A sealant composition is applied to a surface of the porous fibrous substrate and permitted to penetrate the surface pores of the porous fibrous substrate and undergo cure while participating in a foaming reaction with the moisture content to establish a water-resistant polymeric foam sealant impregnated into the porous fibrous substrate. The water-resistant polymeric foam sealant contains a polyurethane and/or polyurea.

Abstract: An impact resistant door skin, a door including the same, and a method of manufacturing an impact resistant door skin from a pre-formed door skin are provided. The method includes the steps of providing at least one preformed door skin and applying adhesive to a rear side of the at least one preformed door skin. A fiberglass mesh mat is pressed onto the rear side of the at least one preformed door skin. Then, chopped glass fibers coated with adhesive are sprayed onto the rear side of the at least one preformed door skin using a chopper gun to form a layer of chopped glass fibers on the fiberglass mesh mat. The performed door skin may be a molded door skin having at least one recessed panel formed therein.

Abstract: An impact resistant door skin, a door including the same, and a method of manufacturing an impact resistant door skin from a pre-formed door skin are provided. The method includes the steps of providing at least one preformed door skin and applying adhesive to a rear side of the at least one preformed door skin. A fiberglass mesh mat is pressed onto the rear side of the at least one preformed door skin. Then, chopped glass fibers coated with adhesive are sprayed onto the rear side of the at least one preformed door skin using a chopper gun to form a layer of chopped glass fibers on the fiberglass mesh mat. The performed door skin may be a molded door skin having at least one recessed panel formed therein.

Abstract: An impact resistant door skin, a door including the same, and a method of manufacturing an impact resistant door skin from a pre-formed door skin are provided. The method includes the steps of providing at least one preformed door skin and applying adhesive to a rear side of the at least one preformed door skin. A fiberglass mesh mat is pressed onto the rear side of the at least one preformed door skin. Then, chopped glass fibers coated with adhesive are sprayed onto the rear side of the at least one preformed door skin using a chopper gun to form a layer of chopped glass fibers on the fiberglass mesh mat. The performed door skin may be a molded door skin having at least one recessed panel formed therein.

Abstract: An impact resistant door skin, a door including the same, and a method of manufacturing an impact resistant door skin from a pre-formed door skin are provided. The method includes the steps of providing at least one preformed door skin and applying adhesive to a rear side of the at least one preformed door skin. A fiberglass mesh mat is pressed onto the rear side of the at least one preformed door skin. Then, chopped glass fibers coated with adhesive are sprayed onto the rear side of the at least one preformed door skin using a chopper gun to form a layer of chopped glass fibers on the fiberglass mesh mat. The performed door skin may be a molded door skin having at least one recessed panel formed therein.

Abstract: A method for suppressing the expression of a selected gene in a cell, the method comprising introducing into the cell a molecule comprising (1) a nucleic acid binding portion which binds to a site or associated with the selected gene which site is present in a genome and (2) an expression repressor portion, wherein the nucleic acid binding portion comprises an oligonucleotide or oligonucleotide mimic or analogue, and wherein the repressor portion comprises a polypeptide or peptidomimetic. Molecules for use in the methods of the invention are provided. The repressor may be a portion of a histone deacetylase or DNA methylase or polypeptide capable of recruiting a histone deacetylase or DNA methylase.