Abstract: Methods and systems are provided for the automated detection and analysis of structural tissue alterations related to myelin and axons/neurons in one or more biological structures of a patient's nervous system obtained from data from a medical imaging system, or the initial sensing or data collection processes such as, those that could be used to generate an image. In some embodiments, the method comprises, at a system having a memory and one or more processor for processing and displaying images of the biological structure, computationally processing at least a T1 weighted magnetic resonance image of the structure and a T2 weighted magnetic resonance image of the structure in order to analyze at least a portion of the structure of the nervous system using a plurality of stored tissue classifier elements to determine if the portion of the structure correlates with the presence of myelin. Such methods are useful for the detection of diseases associated with demyelination.

Abstract: Methods and systems are provided for the automated detection and analysis of structural tissue alterations related to myelin and axons/neurons in one or more biological structures of a patient's nervous system obtained from data from a medical imaging system, or the initial sensing or data collection processes such as, those that could be used to generate an image. In some embodiments, the method comprises, at a system having a memory and one or more processor for processing and displaying images of the biological structure, computationally processing at least a T1 weighted magnetic resonance image of the structure and a T2 weighted magnetic resonance image of the structure in order to analyze at least a portion of the structure of the nervous system using a plurality of stored tissue classifier elements to determine if the portion of the structure correlates with the presence of myelin. Such methods are useful for the detection of diseases associated with demyelination.

Abstract: This invention pertains to the discovery that nerve growth factor (NGF) is capable of preventing further demyelination of nervous tissue in pathologies characterized by the demyelination of nervous tissue (e.g. multiple sclerosis). In one embodiment, this invention provides a method for inhibiting demyelination in a subject having an inflammatory disease of a nervous tissue. The method involves administering an effective amount of NGF, an NGF analogue, or an active fragment of NGF where the effective amount is sufficient to downregulate the production of interferon ? by T cells infiltrating the central nervous system and/or to upregulate IL-10 production by glial cells.

Abstract: An exercise device in which removable weight may be provided in a housing of the device. Two rotatable handles may be provided in the housing, permitting various hand orientations during exercise. The removable weight may be received within and/or removed from a cavity of the device.

Abstract: A method includes a link receiver (304) providing a plurality of data credits (320) to a link transmitter (302) and the link transmitter transmitting a packet (325) to the link receiver, where the link transmitter takes the packet from one of a plurality of logical channels (318), and where the link transmitter selects from which of the plurality of channels to draw the packet. The link receiver transmits a flow control packet (332) to the link transmitter to add additional data credits (334) to the plurality of data credits, where the link transmitter selects to which of the plurality of logical channels to allocate the additional data credits. A plurality of receiver buffers (322) are placed into a free buffer pool (330) as the packet is transmitting out of the plurality of receiver buffers, where the free buffer pool corresponds to additional data credits.

Abstract: A method includes a link receiver (304) providing a plurality of data credits (320) to a link transmitter (302) and the link transmitter transmitting a packet (325) to the link receiver, where the link transmitter takes the packet from one of a plurality of logical channels (318), and where the link transmitter selects from which of the plurality of channels to draw the packet. The link receiver transmits a flow control packet (332) to the link transmitter to add additional data credits (334) to the plurality of data credits, where the link transmitter selects to which of the plurality of logical channels to allocate the additional data credits. A plurality of receiver buffers (322) are placed into a free buffer pool (330) as the packet is transmitting out of the plurality of receiver buffers, where the free buffer pool corresponds to additional data credits.

Abstract: A method includes a link receiver (304) providing a plurality of data credits (320) to a link transmitter (302) and the link transmitter transmitting a packet (325) to the link receiver, where the link transmitter takes the packet from one of a plurality of logical channels (318), and where the link transmitter selects from which of the plurality of channels to draw the packet. The link receiver transmits a flow control packet (332) to the link transmitter to add additional data credits (334) to the plurality of data credits, where the link transmitter selects to which of the plurality of logical channels to allocate the additional data credits. A plurality of receiver buffers (322) are placed into a free buffer pool (330) as the packet is transmitting out of the plurality of receiver buffers, where the free buffer pool corresponds to additional data credits.

Abstract: An exercise device, method of making the device and a method and system for interaction with an exercise device, in which removable, variable weight may be provided in a housing of the device. Two rotatable handles may be provided in the housing, permitting various hand orientations during exercise. The removable weight may be provided near the center of the exercise device, with the handles substantially outboard the weight. Weight may thus be efficiently added or removed in a central area of the housing between the handles.

Abstract: A network and method include communicating among a plurality of left end-node devices (106) across a Clos network (222), communicating between the plurality of left end-node devices and a plurality of right end-node devices (108) across a bi-delta network (221), and communicating among the plurality of right end node devices across a mesh network (323), wherein the Clos network, the bi-delta network and the mesh network are superimposed to operate among a plurality of left side switches (102) and a plurality of right side switches (104).

Abstract: This invention pertains to the discovery that nerve growth factor (NGF) is capable of preventing further demyelination of nervous tissue in pathologies characterized by the demyelination of nervous tissue (e.g. multiple sclerosis). In one embodiment, this invention provides a method for inhibiting demyelination in a subject having an inflammatory disease of a nervous tissue. The method involves administering an effective amount of NGF, an NGF analogue, or an active fragment of NGF where the effective amount is sufficient to downregulate the production of interferon &lgr; by T cells infiltrating the central nervous system and/or to upregulate IL-10 production by glial cells.