Patents by Inventor Stephen Hendricks

Stephen Hendricks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12071618
    Abstract: Compositions, systems, and methods for the display of analytes such as biomolecules are described. Display of analytes is achieved by coupling of the analytes to displaying molecules that are configured to associate with surfaces or interfaces. Arrays of analytes may be formed from the described systems for utilization in assays and other methods.
    Type: Grant
    Filed: January 18, 2024
    Date of Patent: August 27, 2024
    Assignee: Nautilus Subsidiary, Inc.
    Inventors: Tural Aksel, Stephen Hendricks, Elvis Ikwa, Pierre Indermuhle, Sadie Ingle, Christina Inman, Parag Mallick, Torri Elise Rinker, Steven Tan
  • Patent number: 11993807
    Abstract: An affinity reagent, having: (a) a retaining component such as a structured nucleic acid particle; and (b) one or both of (i) one or more label components attached to the retaining component, and (ii) one or more binding components attached to the retaining component.
    Type: Grant
    Filed: March 7, 2023
    Date of Patent: May 28, 2024
    Assignee: Nautilus Subsidiary, Inc.
    Inventors: Tural Aksel, Torri Rinker, Markus Burns, Michael Dorwart, Rachel Galimidi, Dmitriy Gremyachinskiy, Stephen Hendricks, Elvis Ikwa, Gregory Kapp, Joshua Simon Klein, Julia Robinson, Cassandra Stawicki, Sonal Tonapi, Parag Mallick
  • Patent number: 11912990
    Abstract: Compositions, systems, and methods for the display of analytes such as biomolecules are described. Display of analytes is achieved by coupling of the analytes to displaying molecules that are configured to associate with surfaces or interfaces. Arrays of analytes may be formed from the described systems for utilization in assays and other methods.
    Type: Grant
    Filed: July 28, 2023
    Date of Patent: February 27, 2024
    Assignee: NAUTILUS SUBSIDIARY, INC.
    Inventors: Tural Aksel, Stephen Hendricks, Elvis Ikwa, Pierre Indermuhle, Sadie Ingle, Christina Inman, Parag Mallick, Torri Elise Rinker, Steven Tan
  • Patent number: 11760997
    Abstract: Compositions, systems, and methods for the display of analytes such as biomolecules are described. Display of analytes is achieved by coupling of the analytes to displaying molecules that are configured to associate with surfaces or interfaces. Arrays of analytes may be formed from the described systems for utilization in assays and other methods.
    Type: Grant
    Filed: October 28, 2022
    Date of Patent: September 19, 2023
    Assignee: Nautilus Subsidiary, Inc.
    Inventors: Tural Aksel, Stephen Hendricks, Elvis Ikwa, Pierre Indermuhle, Sadie Ingle, Christina Inman, Parag Mallick, Torri Elise Rinker, Steven Tan
  • Patent number: 11692217
    Abstract: An affinity reagent, having: (a) a retaining component such as a structured nucleic acid particle; and (b) one or both of (i) one or more label components attached to the retaining component, and (ii) one or more binding components attached to the retaining component.
    Type: Grant
    Filed: November 10, 2021
    Date of Patent: July 4, 2023
    Assignee: Nautilus Subsidiary, Inc.
    Inventors: Tural Aksel, Torri Rinker, Markus Burns, Michael Dorwart, Rachel Galimidi, Dmitriy Gremyachinskiy, Stephen Hendricks, Elvis Ikwa, Gregory Kapp, Joshua Simon Klein, Julia Robinson, Cassandra Stawicki, Sonal Tonapi, Parag Mallick
  • Patent number: 11661629
    Abstract: Methods, assays, compositions and kits for the ligation of short polynucleotides are presented herein. The short polynucleotides are optionally no more than 7 nucleotides in length, and can be as short as 3 or 4 nucleotides in length. The ligation is optionally performed by CV ligase.
    Type: Grant
    Filed: October 28, 2019
    Date of Patent: May 30, 2023
    Assignee: Life Technologies Corporation
    Inventors: Stephen Hendricks, David J. King
  • Patent number: 11505796
    Abstract: Compositions, systems, and methods for the display of analytes such as biomolecules are described. Display of analytes is achieved by coupling of the analytes to displaying molecules that are configured to associate with surfaces or interfaces. Arrays of analytes may be formed from the described systems for utilization in assays and other methods.
    Type: Grant
    Filed: March 10, 2022
    Date of Patent: November 22, 2022
    Assignee: Nautilus Biotechnology, Inc.
    Inventors: Tural Aksel, Stephen Hendricks, Elvis Ikwa, Pierre Indermuhle, Sadie Ingle, Christina Inman, Parag Mallick, Torri Elise Rinker, Steven Tan
  • Publication number: 20220356236
    Abstract: The present disclosure provides anti-BTC antibodies, methods of producing said antibodies, pharmaceutical compositions comprising said antibodies, and methods of using said antibodies. The present disclosure also provides multi-specific binding molecules, e.g., bispecific antibodies, comprising a BTC binding moiety and an anti-VEGF binding moiety.
    Type: Application
    Filed: June 30, 2022
    Publication date: November 10, 2022
    Inventors: Chad Eric BIGELOW, Ana Maria CARRION, James Edgar CHASTAIN, Kirk Lee CLARK, Bijan Alexandre ETEMAD-GILBERTSON, Joy Gispati GHOSH, Shawn Michael HANKS, Nicole HAUBST, Ganesh Rajan IYER, Nina MOKER, Andrew Anh NGUYEN, Stephen Hendrick POOR, Yubin QIU, Nalini Velamur RANGASWAMY, Michael STEFANIDAKIS, Engin TOKSOZ, Michael Zbigniew TWAROG
  • Publication number: 20220348646
    Abstract: The present disclosure provides anti-BTC antibodies, methods of producing said antibodies, pharmaceutical compositions comprising said antibodies, and methods of using said antibodies. The present disclosure also provides multi-specific binding molecules, e.g., bispecific antibodies, comprising a BTC binding moiety and an anti-VEGF binding moiety.
    Type: Application
    Filed: June 30, 2022
    Publication date: November 3, 2022
    Inventors: Chad Eric BIGELOW, Ana Maria CARRION, James Edgar CHASTAIN, Kirk Lee CLARK, Bijan Alexandre ETEMAD-GILBERTSON, Joy Gispati GHOSH, Shawn Michael HANKS, Nicole HAUBST, Ganesh Rajan IYER, Nina MOKER, Andrew Anh NGUYEN, Stephen Hendrick POOR, Yubin QIU, Nalini Velamur RANGASWAMY, Michael STEFANIDAKIS, Engin TOKSOZ, Michael Zbigniew TWAROG
  • Publication number: 20220025032
    Abstract: The present disclosure provides anti-BTC antibodies, methods of producing said antibodies, pharmaceutical compositions comprising said antibodies, and methods of using said antibodies. The present disclosure also provides multi-specific binding molecules, e.g., bispecific antibodies, comprising a BTC binding moiety and an anti-VEGF binding moiety.
    Type: Application
    Filed: July 14, 2021
    Publication date: January 27, 2022
    Inventors: Chad Eric BIGELOW, Ana Maria CARRION, James Edgar CHASTAIN, Kirk Lee CLARK, Bijan Alexandre ETEMAD-GILBERTSON, Joy Gispati GHOSH, Shawn Michael HANKS, Nicole HAUBST, Ganesh Rajan IYER, Nina MOKER, Andrew Anh NGUYEN, Stephen Hendrick POOR, Yubin QIU, Nalini Velamur RANGASWAMY, Michael STEFANIDAKIS, Engin TOKSOZ, Michael Zbigniew TWAROG
  • Patent number: 11072824
    Abstract: This application relates to methods for ligating oligonucleotides having complementarity to a target nucleic acid, and amplifying the ligated oligonucleotides, where ligation and amplification occur in the same reaction mixture.
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: July 27, 2021
    Assignee: Life Technologies Corporation
    Inventors: Shiaw-Min Chen, Elana Swartzman, David Ruff, Mark Shannon, Julia Lu, Stephen Hendricks
  • Patent number: 10597705
    Abstract: In some embodiments, methods for ligating nucleic acid ends comprise: conducting a nucleic acid ligation reaction in the presence of at least one agent that generates a ligatable terminal 5? phosphate group by removing an adenylate group from a terminal 5? phosphate of a nucleic acid. In some embodiments, an aprataxin enzyme can catalyze removal of an adenylate group from a terminal 5? phosphate of a nucleic acid. In some embodiments, methods for ligating nucleic acid ends comprise: conducting a nucleic acid ligation reaction in the presence of an aprataxin enzyme under conditions suitable for ligating nucleic acid ends.
    Type: Grant
    Filed: October 8, 2018
    Date of Patent: March 24, 2020
    Assignee: Life Technologies Corporation
    Inventors: Stephen Hendricks, David King, Lei Xi, Marian Peris
  • Patent number: 10494671
    Abstract: Methods, assays, compositions and kits for the ligation of short polynucleotides are presented herein. The short polynucleotides are optionally no more than 7 nucleotides in length, and can be as short as 3 or 4 nucleotides in length. The ligation is optionally performed by CV ligase.
    Type: Grant
    Filed: January 17, 2012
    Date of Patent: December 3, 2019
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Stephen Hendricks, David King
  • Patent number: 10472671
    Abstract: This application relates to methods for ligating oligonucleotides having complementarity to a target nucleic acid, and amplifying the ligated oligonucleotides, where ligation and amplification occur in the same reaction mixture.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: November 12, 2019
    Assignee: Life Technologies Corporation
    Inventors: Shiaw-Min Chen, Elana Swartzman, David Ruff, Mark Shannon, Julia Lu, Stephen Hendricks
  • Patent number: 10336991
    Abstract: Provided herein are mutant DNA-dependent polymerases which are derived from, or otherwise related to, wild type RB69 DNA polymerase. These mutant polymerases are capable of selectively binding labeled nucleotides. These mutant polymerases are also capable of incorporating a variety of naturally occurring and modified nucleotides, including, for example, terminator nucleotides.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: July 2, 2019
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Marian Peris, Michael Phelan, Barnett Rosenblum, Stephen Hendricks
  • Patent number: 10093969
    Abstract: In some embodiments, methods for ligating nucleic acid ends comprise: conducting a nucleic acid ligation reaction in the presence of at least one agent that generates a ligatable terminal 5? phosphate group by removing an adenylate group from a terminal 5? phosphate of a nucleic acid. In some embodiments, an aprataxin enzyme can catalyze removal of an adenylate group from a terminal 5? phosphate of a nucleic acid. In some embodiments, methods for ligating nucleic acid ends comprise: conducting a nucleic acid ligation reaction in the presence of an aprataxin enzyme under conditions suitable for ligating nucleic acid ends.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: October 9, 2018
    Assignee: Life Technologies Corporation
    Inventors: Stephen Hendricks, David King, Lei Xi, Marian Peris
  • Patent number: 9765388
    Abstract: In some embodiments, methods for ligating nucleic acid ends comprise: conducting a nucleic acid ligation reaction in the presence of at least one agent that generates a ligatable terminal 5? phosphate group by removing an adenylate group from a terminal 5? phosphate of a nucleic acid. In some embodiments, an aprataxin enzyme can catalyze removal of an adenylate group from a terminal 5? phosphate of a nucleic acid. In some embodiments, methods for ligating nucleic acid ends comprise: conducting a nucleic acid ligation reaction in the presence of an aprataxin enzyme under conditions suitable for ligating nucleic acid ends.
    Type: Grant
    Filed: March 15, 2016
    Date of Patent: September 19, 2017
    Assignee: Life Technologies Corporation
    Inventors: Stephen Hendricks, David King, Lei Xi, Marian Peris
  • Patent number: 9593315
    Abstract: Provided herein are mutant DNA-dependent polymerases which are derived from, or otherwise related to, wild type RB69 DNA polymerase. These mutant polymerases are capable of selectively binding labeled nucleotides. These mutant polymerases are also capable of incorporating a variety of naturally occurring and modified nucleotides, including, for example, terminator nucleotides.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: March 14, 2017
    Assignee: Life Technologies Corporation
    Inventors: Marian Peris, Michael Phelan, Barnett Rosenblum, Stephen Hendricks
  • Publication number: 20170044506
    Abstract: The present invention provides compositions and methods for a reverse transcription reaction using a reversibly inactivated reverse transcriptase enzyme. The reversibly inactivated reverse transcriptase enzyme results from a chemical modification which inactivates the reverse transcriptase enzyme. The activity of the reverse transcriptase enzyme is recovered by an incubation of the reaction mixture at elevated temperature prior to, or as part of the reverse transcription reaction. The reverse transcriptase enzyme of the present invention provides for a significant reduction in non-specific reverse transcription from template nucleic acid molecules because the formulation of the reaction mixture does not support the formation of reverse transcription products prior to activation of the reverse transcriptase.
    Type: Application
    Filed: August 22, 2016
    Publication date: February 16, 2017
    Inventors: Lei (Larry) XI, Roland Nagel, Stephen Hendricks, Jennifer Berkman, Marian Peris, Yulei Wang
  • Patent number: 9476093
    Abstract: This disclosure relates to methods of performing activation by polyphosphorolysis (APP) reactions using at least one of the polyphosphorylating agents triphosphate, polyphosphate, imidodiphosphate, thiodiphosphate (or ?-monothiopyrophosphate), and related compounds.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: October 25, 2016
    Assignee: Life Technologies Corporation
    Inventors: Lei Xi, Paul Kenney, Zhaochun Ma, Dennis Prosen, Stephen Hendricks, Roland Nagel