Patents by Inventor Stephen Henry

Stephen Henry has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic molecule constructs
    Patent number: 10858384
    Abstract: Synthetic molecule construct of the structure F-S1-S2-L where F-S1 is an aminoalkylglycoside and S2-L is a dicarboxylated, e.g. adipylated, phosphatidylethanolamide are disclosed. The two terminal sugars of the aminoalkylglycoside (Gal?1-3Gal?-) are the two terminal sugars of the Galili antigen.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: December 8, 2020
    Assignee: KODE BIOTECH LIMITED
    Inventors: Nicolai Bovin, Lissa Gilliver, Stephen Henry, Elena Korchagina
  • SYNTHETIC MOLECULE CONSTRUCTS
    Publication number: 20200123188
    Abstract: Synthetic molecule construct of the structure F-S1-S2-L where F—S1 is an aminoalkylglycoside and S2-L is a dicarboxylated, e.g. adipylated, phosphatidylethanolamide are disclosed. The two terminal sugars of the aminoalkylglycoside (Gal?1-3Gal?-) are the two terminal sugars of the Galili antigen.
    Type: Application
    Filed: September 16, 2019
    Publication date: April 23, 2020
    Inventors: Nicolai Bovin, Lissa Gilliver, Stephen Henry, Elena Norchagina
  • Synthetic membrane anchors
    Patent number: 10414786
    Abstract: A construct of the structure F—S1-S2 where: F—S1 is an aminoalkylglycoside where F is ?-D-galactopyranosyl-(1?4)-?-D-galactopyranosyl-(1?4)-?-D-glucopyranoside and S1 is 2-aminoethyl, 3-aminopropyl, 4-aminobutyl or 5-aminopentyl; S2 is —CO(CH2)2CO—, —CO(CH2)3CO—, —CO(CH2)4CO— or —CO(CH2)5CO—; and L is phosphatidylethanolamine.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: September 17, 2019
    Assignee: KODE BIOTECH LIMITED
    Inventors: Nicolai Bovin, Lissa Gilliver, Stephen Henry, Elena Korchagina
  • Functionalizing nanofibres
    Patent number: 10213514
    Abstract: Methods for functionalizing the surface of nanofiber substrates, including electrospun fibers and non-woven or woven mats of fibers are described. Functionalized nanofiber substrates presenting biologically active moieties such as biotin and saccharides are described.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: February 26, 2019
    Inventors: Nicolai Bovin, Stephen Henry, Iain Hosie, Stephen Parker
  • GLYCOLIPID COMPOUNDS AND THEIR USES IN THE TREATMENT OF TUMOURS
    Publication number: 20180344805
    Abstract: The invention relates to novel glycolipid compounds and pharmaceutical compositions comprising said glycolipids and to processes for preparing said glycolipids. The invention also relates to said glycolipids for use in treating tumours and methods of treating tumours using said glycolipids.
    Type: Application
    Filed: November 15, 2015
    Publication date: December 6, 2018
    Inventors: Graham GRIFFITHS, Stephen SHAW, Nicolai Vladimirovich BOVIN, Alexander Borisovich TUZIKOV, Elena Yurievna KORCHAGINA, Stephen HENRY
  • In vivo methods of monitoring biodistribution
    Patent number: 10040823
    Abstract: Functional-lipid constructs of the structure F-S-L are disclosed, wherein F comprises a tyrosine or histidine residue, S is a spacer covalently linking F to L and L is a lipid. The functional residue may be iodinated and used to radiolabel a biological entity with 1251 and the iodinated constructs are used in a non-invasive method of monitoring the distribution of a biological entity in vivo.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: August 7, 2018
    Assignee: KODE BIOTECH LIMITED
    Inventors: Nikolai Vladimirovich Bovin, Stephen Henry, Elena Yurievna Korchagina, Igor Leonidovich Rodionov, Alexander Borisovich Tuzikov
  • SYNTHETIC MEMBRANE ANCHORS
    Publication number: 20180057518
    Abstract: A construct of the structure F—S1-S2 where: F—S1 is an aminoalkylglycoside where F is ?-D-galactopyranosyl-(1?4)-B-D-galactopyranosyl-(1?4)-?-D-glucopyranoside and S1 is 2-aminoethyl, 3-aminopropyl, 4-aminobutyl or 5-aminopentyl; S2 is —CO(CH2)2CO—, —CO(CH2)3CO—, —CO(CH2)4CO— or —CO(CH2)5CO—; and L is phosphatidylethanolamine.
    Type: Application
    Filed: November 6, 2017
    Publication date: March 1, 2018
    Inventors: Nicolai Bovin, Lissa Gilliver, Stephen Henry, Elena Korchagina
  • In vivo methods of monitoring biodistribution
    Patent number: 9821080
    Abstract: Non-invasive method of monitoring by radioactivity bioscanning the distribution of a biological entity in a subject in vivo by administering to the subject a radioiodinated form of the biological entity. The radioiodinated form is prepared by contacting an aqueous suspension of the biological entity with a radioiodinated construct of the structure F-S-L where F comprises a radioiodinated tyrosine moiety, S is a spacer covalently linking F to L, and L is a lipid.
    Type: Grant
    Filed: February 9, 2012
    Date of Patent: November 21, 2017
    Inventors: Nikolai Vladimirovich Bovin, Stephen Henry, Elena Yurievna Korchagina, Igor Leonidovich Rodionov, Alexander Borisovich Tuzikov
  • Functionalizing nanofibres
    Patent number: 9814786
    Abstract: Methods of preparing a functionalized nanofiber preparing a dispersion of a polymer and a water soluble synthetic construct of the structure F-S-L in admixture in a liquid medium; and then electrospinning the polymer from the liquid medium to provide the functionalized nanofiber. F is the functional moiety, L is a lipid and S is a spacer linking F to L via covalent bonds.
    Type: Grant
    Filed: December 2, 2014
    Date of Patent: November 14, 2017
    Inventors: Nicolai Bovin, Stephen Henry, Iain Hosie, Stephen Parker
  • Synthetic membrane anchors
    Patent number: 9809614
    Abstract: Cells incorporating a synthetic molecule construct of the structure F—S1—S2-L where: F—S1 is an aminoalkylglycoside where F is a mono-, di-, tri- or oligo-saccharide and S1 is 2-aminoethyl, 3-aminopropyl, 4-aminobutyl, or 5-aminopentyl; S2 is —CO(CH2)2CO—, —CO(CH2)3CO—, —CO(CH2)4CO— or —CO(CH2)5CO—; and L is phosphatidylethanolamine.
    Type: Grant
    Filed: May 30, 2016
    Date of Patent: November 7, 2017
    Assignee: KODE BIOTECH LIMITED
    Inventors: Nicolai Bovin, Lissa Gilliver, Stephen Henry, Elena Korchagina
  • FUNCTIONALIZING NANOFIBRES
    Publication number: 20170252460
    Abstract: Methods for functionalizing the surface of nanofiber substrates, including electrospun fibres and non-woven or woven mats of fibres are described. Functionalised nanofiber substrates presenting biologically active moieties such as biotin and saccharides are described.
    Type: Application
    Filed: May 18, 2017
    Publication date: September 7, 2017
    Inventors: Nicolai Bovin, Stephen HENRY, Iain HOSIE, Stephen PARKER
  • VIVO METHODS OF MONITORING BIODISTRIBUTION
    Publication number: 20170240597
    Abstract: Functional-lipid constructs of the structure F-S-L are disclosed, wherein F comprises a tyrosine or histidine residue, S is a spacer covalently linking F to L and L is a lipid. The functional residue may be iodinated and used to radiolabel a biological entity with 1251 and the iodinated constructs are used in a non-invasive method of monitoring the distribution of a biological entity in vivo.
    Type: Application
    Filed: April 18, 2017
    Publication date: August 24, 2017
    Inventors: Nikolai Vladimirovich Bovin, Stephen Henry, Elena Yurievna Korchagina, Igor Leonidovich Rodionov, Alexander Borisovich Tuzikov
  • FLUORESCENT CELL MARKERS
    Publication number: 20170082642
    Abstract: The preparation and use of fluorescent cell markers of the structure F-S1-S2-L is described where F is a fluorophore, S1-S2 is a spacer linking F to L, and L is a diacyl lipid.
    Type: Application
    Filed: September 29, 2016
    Publication date: March 23, 2017
    Inventors: Elena KORCHAGINA, Nicolai BOVIN, Stephen HENRY
  • SYNTHETIC MEMBRANE ANCHORS
    Publication number: 20160333044
    Abstract: Cells incorporating a synthetic molecule construct of the structure F—S1—S2-L where: F—S1 is an aminoalkylglycoside where F is a mono-, di-, tri- or oligo-saccharide and S1 is 2-aminoethyl, 3-aminopropyl, 4-aminobutyl, or 5-aminopentyl; S2 is —CO(CH2)2CO—, —CO(CH2)3CO—, —CO(CH2)4CO— or —CO(CH2)5CO—; and L is phosphatidylethanolamine.
    Type: Application
    Filed: May 30, 2016
    Publication date: November 17, 2016
    Inventors: Nicolai BOVIN, Lissa Gilliver, Stephen Henry, Elena Korchagina
  • FUNCTIONALIZING NANOFIBRES
    Publication number: 20160296636
    Abstract: Methods for functionalizing the surface of nanofibre substrates, including electrospun fibres and non-woven or woven mats of fibres are described. Functionalised nanofibre substrates presenting biologically active moieties such as biotin and saccharides are described.
    Type: Application
    Filed: December 2, 2014
    Publication date: October 13, 2016
    Inventors: Nicolai BOVIN, Stephen HENRY, Iain HOSIE, Stephen PARKER
  • Synthetic membrane anchors
    Patent number: 9353349
    Abstract: Cells incorporating a synthetic molecule construct of the structure F—S1-S2-L where: F—S1 is an aminoalkylglycoside where F is a mono-, di-, tri- or oligo-saccharide and S1 is 2-aminoethyl, 3-aminopropyl, 4-aminobutyl, or 5-aminopentyl; S2 is —CO(CH2)2CO—, —CO(CH2)3CO—, —CO(CH2)4CO— or —CO(CH2)5CO—; and L is phosphatidylethanolamine.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: May 31, 2016
    Assignee: KODE BIOTECH LIMITED
    Inventors: Nicolai Bovin, Lissa Gilliver, Stephen Henry, Elena Korchagina
  • FLUORESCENT CELL MARKERS
    Publication number: 20150204848
    Abstract: The preparation and use of fluorescent cell markers of the structure F—S1-S2-L is described where F is a fluorophore, S1-S2 is a spacer linking F to L, and L is a diacyl lipid.
    Type: Application
    Filed: December 8, 2014
    Publication date: July 23, 2015
    Inventors: Elena KORCHAGINA, Nicolai BOVIN, Stephen HENRY
  • SYNTHETIC MEMBRANE ANCHORS
    Publication number: 20140186950
    Abstract: Cells incorporating a synthetic molecule construct of the structure F—S1—S2-L where: F—S1 is an aminoalkylglycoside where F is a mono-, di-, tri- or oligo-saccharide and S1 is 2-aminoethyl, 3-aminopropyl, 4-aminobutyl, or 5-aminopentyl; S2 is —CO(CH2)2CO—, —CO(CH2)3CO—, —CO(CH2)4CO— or —CO(CH2)5CO—; and L is phosphatidylethanolamine.
    Type: Application
    Filed: December 17, 2013
    Publication date: July 3, 2014
    Applicant: Kode Biotech Limited
    Inventors: Nicolai Bovin, Lissa Gilliver, Stephen Henry, Elena Korchagina
  • IN VIVO METHODS OF MONITORING BIODISTRIBUTION
    Publication number: 20140161723
    Abstract: Functional-lipid constructs of the structure F-S-L are disclosed, wherein F comprises a tyrosine or histidine residue, S is a spacer covalently linking F to L and L is a lipid. The functional residue may be iodinated and used to radiolabel a biological entity with 1251 and the iodinated constructs are used in a non-invasive method of monitoring the distribution of a biological entity in vivo.
    Type: Application
    Filed: February 9, 2012
    Publication date: June 12, 2014
    Inventors: Nikolai Vladimirovich Bovin, Stephen Henry, Elena Yurievna Korchagina, Igor Leonidovich Rodionov, Alexander Borisovich Tuzikov
  • Synthetic membrane anchors
    Patent number: 8637473
    Abstract: Synthetic molecule construct of the structure F—S1—S2-L where F is an O-linked mono-, di-, tri- or oligo-saccharide, S1 is 2-aminoethyl, 3-aminopropyl, 4-aminobutyl, or 5-aminopentyl, S2 is —CO(CH2)2CO—, —CO(CH2)3CO—, —CO(CH2)4CO— or —CO(CH2)5CO—, and L is a diacyl- or dialkyl-glycerophospholipid.
    Type: Grant
    Filed: May 3, 2011
    Date of Patent: January 28, 2014
    Assignee: Kode Biotech Limited
    Inventors: Nicolai Bovin, Lissa Gilliver, Stephen Henry, Elena Korchagina