Abstract: The present invention relates to 1-N-amino-2-imidazolidinones and derivatives thereof which are effective as Kv1.5 potassium channel inhibitors providing atrial-selective antiarrhythmic agents. The present invention further relates to compositions comprising said Kv1.5 potassium channel inhibitors, and to methods for treating cardiac arrhythmia.

Abstract: The present invention relates to 4-oxo-1,3,8-triaza-spiro[4.5]decanes which are useful as Kv1.5 potassium channel inhibitors providing atrial-selective antiarrhythmic activity. The present invention further relates to compositions and methods for treating atrial-selective antiarrhythmia.

Abstract: A range of extruded polymers incorporating synthetic furanones was manufactured and field tested. Polymers incorporating furanones showed excellent antifouling efficacy and significantly reduced fouling for more than 100 days. The present inventors have developed polymers that release commercial short-lived biocides or analogues of antifouling compounds isolated from marine algae. A range of polymers incorporating either the commercial isothiazolone Sea-Nine 211™ or a halogenated furanone were effective antifouling treatments in laboratory and field trials. The efficacy of the polymers was dependant on polymer type and the initial concentration of the antifouling compound. The polymers can be extruded as filaments that can be woven into netting or extruded or molding for other applications.