Abstract: Cell-targeted cytotoxic compounds are provided herein. Such compounds can be used, e.g., to selectively bind and kill cancer cells such as cancer stem cells that express LGR4, LGR5, or LGR6. In some embodiments, the cytotoxic compounds include an LGR binding polypeptide, a cytotoxic agent (e.g., MMAE), and an Fc region (e.g., a mutant Fc domain). Methods for using the compounds to treat cell proliferative diseases such as cancers are also provided.

Abstract: A tibial-femoral trial implant comprises a femoral trial insert, which comprises a medial condyle and a lateral condyle, and a tibial trial insert, which comprises a medial plate and a lateral plate. The implant further comprises a graduated reference system adapted to indicate the relative angular deviation between the femoral trial insert and the tibial trial insert about a vertical axis, passing through the center of a sphere defining the medial condyle of the femoral trial insert, following a roto-translational movement of the femoral trial insert from a first position, identifying a knee extension position, to a second position, identifying a knee flexion position.

Abstract: The present disclosure relates to a guide device for tibial resection comprising a guide jig having a slot for a surgical saw, a first feeler provided for coming into contact with a point of a tibial plateau and a second feeler provided for coming into contact with a point of a tibial plateau. The first feeler and the second feeler can be rotated with respect to one another and to the guide jig around the same rotation axis and the first feeler can be translated with respect to the second feeler and to the guide jig along a first sliding direction contained within a first sliding plane. The second feeler can be translated with respect to the first feeler and with respect to the guide jig along a second sliding direction contained in a second sliding plane parallel to the first sliding plane.

Abstract: A method of controlling the stopping and starting of an engine is disclosed in which, during an engine shut-down period, if a signal indicative of a request for restarting the engine is generated, the engine 1000 is restarted if the engine speed (N) is within a predefined speed range and the absolute pressure (MAP) in a manifold of the engine is below a predefined limit MAPlim.

Abstract: Input/output (I/O) I/O target selection is achieved within a data storage system having clustered nodes of initiators, I/O targets, and grouped storage logical units. A state definition component defines access states for each combination of one or more combinations of a node, an I/O target, and a storage logical unit. A profiler component produces an access state profile for each I/O target. A rank criteria compiler compiles rank criteria as a basis for best-fit identification of I/O targets for a logical unit (LU) group. A best-fit identifier is responsive to the profile component and the rank criteria compiler and identifies a ranked best-fit order of I/O targets for an LU group. A target selector selects an I/O target for an LU group from the ranked best-fit order.

Abstract: A method of controlling the stopping and starting of an engine is disclosed in which, during an engine shut-down period, if a signal indicative of a request for restarting the engine is generated, the engine 1000 is restarted if the engine speed (N) is within a predefined speed range and the absolute pressure (MAP) in a manifold of the engine is below a predefined limit MAPlim.

Abstract: The invention is in general directed to acid-sensitive linkers, and methods of use thereof, such as, for example, in drug delivery methods.

Abstract: A method in a mobile wireless communications network including sending (210) a reselection communication from a mobile station to the network, and receiving (220), from the network in response to the reselection communication, cell reselection assistance information, for example, a new cell assignment.

Abstract: The invention is in general directed to acid-sensitive linkers, and methods of use thereof, such as, for example, in drug delivery methods.

Abstract: Input/output (I/O) I/O target selection is achieved within a data storage system having clustered nodes of initiators, I/O targets, and grouped storage logical units. A state definition component defines access states for each combination of one or more combinations of a node, an I/O target, and a storage logical unit. A profiler component produces an access state profile for each I/O target. A rank criteria compiler compiles rank criteria as a basis for best-fit identification of I/O targets for a logical unit (LU) group. A best-fit identifier is responsive to the profile component and the rank criteria compiler and identifies a ranked best-fit order of I/O targets for an LU group. A target selector selects an I/O target for an LU group from the ranked best-fit order.

Abstract: A glyceride compound comprising a first aliphatic group and a first substituent group bonded to said first aliphatic group. The first substituent group has the formula —O(CH2CH2O)nP where n is 1 to 14 and P is a polymerisable group. An aqueous emulsion of the glyceride can be used in an emulsion polymerisation reaction to yield a polymer resin, which can then be mixed with a suitable base material, such as wood strands, to produce a composite material, such as Oriented Strand Board.

Abstract: Arthroplasty jigs, arthroplasty jig blanks, and related methods and devices are disclosed. Some variations of the methods comprise forming an arthroplasty jig from a near-shape arthroplasty jig blank, where the near-shape arthroplasty jig blank has at least one feature specific to a target site to be matched by the arthroplasty jig. Certain of the methods comprise forming an arthroplasty jig having a first configuration from a near-shape arthroplasty jig blank having a second configuration approximating the first configuration. Some of the methods comprise forming a near-shape arthroplasty jig blank, where the near-shape arthroplasty jig blank is configured to be formed into an arthroplasty jig, and the near-shape arthroplasty jig blank has at least one feature specific to a target site to be matched by the arthroplasty jig.

Abstract: An apparatus and method for fixation of a soft tissue graft. The apparatus may include a member having a first surface and a second surface. Each of the surfaces extend a distance relative to one another. A member is operable to resist movement of the apparatus relative to an anatomical portion. An interference member may be provided to fixedly associate the apparatus with the anatomical structure.

Abstract: An improved a tool for aiding in laying a brick wall a set distance from the base wall of a structure, and to confirm the verticality of the brick wall. The tool has an elongated member having a smooth face for contacting a wall of bricks, an end member is attached to the end of the elongated member at a right angle thereto, the end member being attached in an adjustable manner. The method of using the tool is also disclosed.

Abstract: A method facilitates assembling a gas turbine engine. The method comprises coupling a combustor including a dome assembly and a combustor liner that extends downstream from the dome assembly to a combustor casing that is positioned radially outwardly from the combustor, coupling a ring support that includes a first radial flange, a second radial flange, and a plurality of beams that extend therebetween to the combustor casing, and coupling a primer nozzle including an injection tip to the combustor such that the primer nozzle extends axially through the dome assembly such that fuel may be discharged from the primer nozzle into the combustor during engine start-up operating conditions.

Abstract: A gas turbine engine combustor carburetor includes forward and aft air swirlers. The aft swirler has a septum defining a primary venturi and a plurality of circumferentially spaced aft swirl vanes. The forward swirler has a plurality of circumferentially spaced forward swirl vanes extending forwardly from a flat annular radial flange of the forward swirler, an annular wall extending forwardly from a forward face of the septum and radially bounding an annular recess on the forward face, and the radial flange slidably retained within the annular recess and against the septum by a flat retainer attached to the annular wall of the septum. The flat retainer may be produced by stamping. An anti-rotation tab on the radial flange of the forward swirler extends radially through a corresponding notch in the annular wall.

Abstract: A method for reducing wireless communication procedure failure. The method can include initiating a procedure over an existing radio resource control connection on a universal mobile telecommunication system. The method can also include receiving a connection release signal prior to receiving a response from a core network regarding the initiated procedure. The method can further include immediately retrying the procedure.

Abstract: The Kwik Leads will enable the ease of brick laying and improve the quality in the manufacture of homes and commercial buildings. The inventive device includes several pieces of various metals that are drilled, tapped, and slotted. With a handle used to hold the tool. 3? by 0.500 by 1? aluminum block which connects the scale to the adjustment bracket. 0.250 by 3.500? by 7.250? plate. 0.250 by 3.500 by 16.00? plate.