Abstract: A dry powder inhaler includes a tray including a slitting chamber for accommodating a spherocylindrical capsule; a main body configured to receive the tray; the tray and main body moving in use between an open and a closed position; the tray and main body further configured so that as the tray and main body move to the closed position, a capsule in the slitting chamber is squeezed across its length to an oval cross-sectional shape by converging walls; the tray further including a blade adapted to slit or pierce the capsule in the tray when the tray is at or close to the closed position, the blade engaging the capsule surface at a position having a radius of curvature smaller than that of the capsule before the capsule was squeezed.

Abstract: Disclosed is a medicament dispenser for holding at least one elongate form medicament carrier. The elongate form medicament carrier has proximal and distal ends, and blister and lid elongate sheets enclosing multiple distinct medicament dose portions therebetween. The medicament dispenser has a dispensing mechanism which is adapted to operate, upon each actuation thereof, to dispense medicament active from the medicament dose portion. Moreover, the mechanism has at least one power spring mechanism for winding the lid elongate sheet, wherein the at least one power spring mechanism has at least one spring having an inner end about which the spring unwinds, and at least one shaft at which the inner end of at least one spring is secured. Furthermore, the power spring mechanism tensions and peels a segment of lid elongate sheet peeled from a corresponding segment of blister elongate sheet upon each actuation of the medicament dispenser.

Abstract: In general terms the present invention proposes a medicament dispenser 100 for use with at least one medicament carrier carrying multiple distinct medicament dose portions. The medicament dispenser 100 comprises: (a) a dispensing mechanism actuable for dispensing the dose portions carried by the at least one medicament carrier; (b) a mouthpiece 106; and (c) a cover for the mouthpiece, the cover being movably mounted to the dispenser 100 for sequential movement from a closed position in which the mouthpiece 106 is at least partially covered, to an open position in which the mouthpiece 106 is uncovered, via a first position, and optionally via a second position between the first position and the closed position that includes the closed position.

Abstract: Disclosed is a medicament dispenser for holding at least one elongate form medicament carrier. The elongate form medicament carrier has proximal and distal ends, and blister and lid elongate sheets enclosing multiple distinct medicament dose portions therebetween. The medicament dispenser has a dispensing mechanism which is adapted to operate, upon each actuation thereof, to dispense medicament active from the medicament dose portion. Moreover, the mechanism has at least one power spring mechanism for winding the lid elongate sheet, wherein the at least one power spring mechanism has at least one spring having an inner end about which the spring unwinds, and at least one shaft at which the inner end of at least one spring is secured. Furthermore, the power spring mechanism tensions and peels a segment of lid elongate sheet peeled from a corresponding segment of blister elongate sheet upon each actuation of the medicament dispenser.

Abstract: A medicament dispenser, and a method of assembling a medicament dispenser, for holding at least one elongate form medicament carrier having blister and lid elongate sheets enclosing multiple distinct medicament dose portions therebetween. The medicament dispenser has a dispensing mechanism which is adapted to operate, upon each actuation thereof, to dispense medicament active from the medicament dose portion. Moreover, the mechanism has at least one power spring mechanism for winding the lid elongate sheet, wherein the at least one power spring mechanism has at least one spring having an inner end about which the spring unwinds, and at least one shaft at which the inner end of at least one spring is secured. Furthermore, the power spring mechanism tensions and peels a segment of lid elongate sheet peeled from a corresponding segment of blister elongate sheet upon each actuation of the medicament dispenser.

Abstract: A metered dose inhaler valve (26) has a reservoir portion (37) for assembly with a canister (14) for receiving a pressurised formulation of medicament and propellant, a metering valve body (96) defining a metering chamber, and a metering valve stem (24) having an outlet (56) and being axially moveable within the body. The stem moves between a first position in which the chamber is in fluid communication with the canister, and a second position in which the chamber is in fluid communication with the valve stem outlet. A metering valve seal is defined by the valve body and includes an opening through which the stem passes to form a dynamic seal between the stem and at least one of the outside atmosphere and the pressurized canister, where the opening is adapted to be stretched wider by the stem passing through it than it would be absent the valve stem.

Abstract: A liquid delivery device has a lower housing containing a reservoir and an upper housing containing a nozzle assembly with an upper tube housing, a passage formed through the upper tube housing between the reservoir and the nozzle assembly, the passage within the upper tube housing forming a metering chamber; the nozzle assembly converting liquid from the metering chamber to a droplet spray; the liquid delivery device having a one-way valve that locates and seals within the passage; the valve configured so that in a first state fluid flow through the passage is substantially blocked, and in a second state fluid can flow through the passage; the valve deforming from the first state to the second state, the upper tube housing comprising a recess at the upper end, the recess configured to receive and confine the outer side of the one-way valve.

Abstract: A dry powder inhalation device has a means to aerosolize powdered medicament and introduce the aerosolized medicament to an airflow directed to a user outlet. The device has a primary deagglomeration structure in the form of a baffle through which the airflow passes downstream of the means to aerosolize the powdered medicament and a secondary deagglomeration structure which is a tortuous passage through which the airflow passes downstream of the primary deagglomeration structure. The deagglomeration structures cause disruption to the airflow in their vicinity whereby the particles of the aerosolized powdered medicament are deagglomerated due to the primary deagglomeration structure and the secondary deagglomeration structure. The insert defines a tortuous passage which has a trajectory with a centre line, whereby the centre line has two or more major bends, involving a first point of inflection between a pair of adjacent bends of the two or more major bends.

Abstract: Disclosed is a medicament dispenser for holding at least one elongate form medicament carrier. The elongate form medicament carrier has proximal and distal ends, and blister and lid elongate sheets enclosing multiple distinct medicament dose portions therebetween. The medicament dispenser has a dispensing mechanism which is adapted to operate, upon each actuation thereof, to dispense medicament active from the medicament dose portion. Moreover, the mechanism has at least one power spring mechanism for winding the lid elongate sheet, wherein the at least one power spring mechanism has at least one spring having an inner end about which the spring unwinds, and at least one shaft at which the inner end of at least one spring is secured. Furthermore, the power spring mechanism tensions and peels a segment of lid elongate sheet peeled from a corresponding segment of blister elongate sheet upon each actuation of the medicament dispenser.

Abstract: In general terms the present invention proposes a medicament dispenser 100 for use with at least one medicament carrier carrying multiple distinct medicament dose portions. The medicament dispenser 100 comprises: (a) a dispensing mechanism actuable for dispensing the dose portions carried by the at least one medicament carrier; (b) a mouthpiece 106; and (c) a cover for the mouthpiece, the cover being movably mounted to the dispenser 100 for sequential movement from a closed position in which the mouthpiece 106 is at least partially covered, to an open position in which the mouthpiece 106 is uncovered, via a first position, and optionally via a second position between the first position and the closed position that includes the closed position.

Abstract: Various embodiments of a device for delivery of a medicament and a method of utilizing such device are disclosed. The device can include a canister and an actuator. The actuator includes a housing receiving the canister; a valve block receiving a metering valve of the canister, the valve block defining an expansion chamber for passage of propellant and medicament expelled from the canister; and a nosepiece for insertion into a user's nostril, the nosepiece including a fluid passage and a delivery opening for expulsion of the propellant and medicament into the user's nostril. A flow path is defined through the actuator for passage of propellant and medicament from the canister and includes the expansion chamber, the fluid passage and the delivery opening. Further, the cross-sectional area of the flow path is greater than the lowest cross-sectional area of the metering valve at all points along the flow path.

Abstract: An inhalation device comprising a hermetically sealed receptacle (1) containing a single dose of a pressurized formulation (30) comprising a pharmaceutically active ingredient and a liquefied aerosol propellant consisting of HFA 134a, HFA 227 or a mixture thereof and wherein at least a portion (12) of the receptacle is perforable.