Abstract: The invention provides an oral dosage form comprising (i) an amount of oxycodone and (ii) an amount of buprenorphine, wherein the weight ratio of the amount of buprenorphine to the amount of oxycodone is greater than 1:40 calculated with the amount of buprenorphine in the dosage form expressed as the equimolar amount of buprenorphine base (Mw=467.64 g/mol) in mg, and the amount of oxycodone in the dosage form expressed as the equimolar amount of oxycodone hydrochloride (Mw=351.82 g/mol) in mg. The invention also provides combinations of an opioid agonist and buprenorphine for use to treat pain, wherein the combination achieves a reduction of adverse pharmacodynamic responses (such as, respiratory depression), compared with a corresponding stand-alone opioid therapy. The invention also includes methods of treatment and dosage forms thereof comprising such combinations.

Abstract: The present disclosure provides a novel approach, recomSELEX, that highly integrate mutually supportive recombination and computational methods for aptamer selection and identification. The recomSELEX approach comprises a recombinatorial SELEX platform for aptamer screening that exponentially increases the sequence space that is explored by incorporation of a DNA shuffling step that allows recombination between aptamers. Subsequently, the recombinatorial SELEX platform can also be employed to develop new and optimize already existing aptamers. The recomSELEX further comprises a computational SELEX platform with a constrained genetic algorithm (GA) to identify potential aptamers that are stable and have the desired specificity and affinity of a target.

Abstract: The present invention is a direct current generating machine that eliminates the need for brushes or other mechanical commutators. A pair of opposed, spaced apart rotatable rotors, each carrying a plurality of bar magnets, are synchronously rotated about a common axis of rotation. A stationary electrically conducting wire extends through the axis of rotation, and radially outwardly therefrom, between the rotating magnetic field. In another embodiment the bar magnets are replaced by pieces of steel which interrupt a unidirectional, magnetic field created by a magnet. The magnet used to create the unidirectional, magnetic field may be an electromagnet. The resultant electrical signal generated in the conductor is unidirectional. The present invention may be used to create brushless DC electrical signals, brushless three-phase DC electrical signals, or a plurality of DC and/or inverted DC signals.

Abstract: The present invention is a direct current generating machine that eliminates the need for brushes or other mechanical commutators. A pair of opposed, spaced apart rotatable rotors, each carrying a plurality of bar magnets, are synchronously rotated about a common axis of rotation. A stationary electrically conducting wire extends through the axis of rotation, and radially outwardly therefrom, between the rotating magnetic field. In another embodiment the bar magnets are replaced by pieces of steel which interrupt a unidirectional, magnetic field created by a magnet. The magnet used to create the unidirectional, magnetic field may be an electromagnet. The resultant electrical signal generated in the conductor is unidirectional. The present invention may be used to create brushless DC electrical signals, brushless three-phase DC electrical signals, or a plurality of DC and/or inverted DC signals.