Abstract: A promoter for high level and sustained expression is provided which can be used for gene expression of chosen sequences in general. In particular, a nucleic acid construct comprising a hCEF1 promoter operably linked to a sequence for expression is provided, where the hCEF1 promoter comprises: (i) a human CMV enhancer operably linked to a human EFI a promoter; (ii) a functional fragment of (i); or (ii) a functional variant of (i) or (ii).

Abstract: A sight assembly for mounting to a weapon. A holographic optical element and a light source are in a fixed angular configuration with respect to one another, but may be adjusted either together or individually in a horizontal or vertical direction. The sight assembly may have a mirror or lens. An adjustment mechanism is provided where a shaft includes at least two portions wherein the two portions of the shaft of the screw have different pitch directions and/or pitch dimensions allowing for slight adjustment the assembly. The light source may be a vertical-cavity surface emitting laser (VCSEL). A temperature sensor may sense a temperature of the VCSEL. A current to the VCSEL may be adjusted based on a change in the temperature such that the output wavelength is approximately the same as a desired wavelength. The assembly may further allow for perceived image distance adjustment using parallax mismatch.

Abstract: A sight assembly for mounting to a weapon is provided. A holographic optical element and a light source are provided in a fixed angular configuration with respect to one another, but may be adjusted either together or individually in a horizontal or vertical direction. A mirror or lens may also be provided. An adjustment mechanism is provided where a shaft includes at least two portions wherein the two portions of the shaft of the screw have different pitch directions and/or pitch dimensions allowing for slight adjustment of the assembly. The light source is typically a vertical-cavity surface emitting laser (VCSEL). The wavelength of the VCSEL is controlled by controlling the current it is given. The assembly further allows for perceived image distance adjustment using parallax mismatch. Further, a chassis is provided for holding holographic elements.

Abstract: A compact weapon sight has a housing with a base that is configured to mount to a weapon. The sight may have a holographic optical element (HOE) and a light source. The light source may be a vertical-cavity surface emitting laser (VCSEL) diode. The wavelength of the VCSEL may be adjusted by controlling the current drawn by the VCSEL and may include a temperature controller to keep the temperature of the light source at or above a minimum threshold temperature without using a thermoelectric cooler or a wavelength sensor.

Abstract: An adjustable holographic gun sight has a base and a carrier pivotally connected to the base. An adjustment mechanism may be adapted to pivot the carrier with respect to the base. A pair of dropouts connects the carrier to the base and the dropouts allow the carrier to pivot with respect to the base. The dropouts may be mounted to an external portion of the carrier and the base thereby provides for external adjustment of the gun sight.

Abstract: A sight assembly for mounting to a weapon. A holographic optical element and a light source are in a fixed angular configuration with respect to one another, but may be adjusted either together or individually in a horizontal or vertical direction. The sight assembly may have a mirror or lens. An adjustment mechanism is provided where a shaft includes at least two portions wherein the two portions of the shaft of the screw have different pitch directions and/or pitch dimensions allowing for slight adjustment the assembly. The light source may be a vertical-cavity surface emitting laser (VCSEL). A temperature sensor may sense a temperature of the VCSEL. A current to the VCSEL may be adjusted based on a change in the temperature such that the output wavelength is approximately the same as a desired wavelength. The assembly may further allow for perceived image distance adjustment using parallax mismatch.

Abstract: A sight assembly for mounting to a weapon is provided. A holographic optical element and a light source are provided in a fixed angular configuration with respect to one another, but may be adjusted either together or individually in a horizontal or vertical direction. A mirror or lens may also be provided. An adjustment mechanism is provided where a shaft includes at least two portions wherein the two portions of the shaft of the screw have different pitch directions and/or pitch dimensions allowing for slight adjustment the assembly. The light source is typically a vertical-cavity surface emitting laser (VCSEL). The wavelength of the VCSEL is controlled by controlling the current it is given. The assembly further allows for perceived image distance adjustment using parallax mismatch. Further, a chassis is provided for holding holographic elements.

Abstract: A promoter for high level and sustained expression is provided which can be used for gene expression of chosen sequences in general. In particular, a nucleic acid construct comprising a hCEF1 promoter operably linked to a sequence for expression is provided, where the hCEF1 promoter comprises: (i) a human CMV enhancer operably linked to a human EFI a promoter; (ii) a functional fragment of (i); or (ii) a functional variant of (i) or (ii).

Abstract: A holographic weapon sight folds for storage or to position where a portion of the sight is out of the way when not in use. Certain embodiments include a readout beam source mounted to the stationary base of the sight and the source directly illuminates a hologram plate supported in a pivotally mounted hologram support when the sight is in a position intended for use.

Abstract: A promoter for high level and sustained expression is provided which can be used for gene expression of chosen sequences in general. In particular, a nucleic acid construct comprising a hCEF1 promoter operably linked to a sequence for expression is provided, where the hCEF1 promoter comprises: (i) a human CMV enhancer operably linked to a human EF1 a promoter; (ii) a functional fragment of (i); or (ii) a functional variant of (i) or (ii).

Abstract: The present invention relates to medicaments for the treatment of cystic fibrosis. Also provided are methods of preparing such medicaments so that they can be used in a treatment regime for cystic fibrosis. The present invention also provides a kit of parts including the medicament of the invention, as well as treatment regimes for cystic fibrosis.

Abstract: A promoter for high level and sustained expression is provided which can be used for gene expression of chosen sequences in general. In particular, a nucleic acid construct comprising a hCEF1 promoter operably linked to a sequence for expression is provided, where the hCEF1 promoter comprises: (i) a human CMV enhancer operably linked to a human EF1 a promoter; (ii) a functional fragment of (i); or (ii) a functional variant of (i) or (ii).

Abstract: An electronic drive system using a plurality of drive circuits for enabling greater plurality of functions by selectively placing drive signals on the driver outputs at one of two possible polarities. At least one of the enabled functions taking a substantially shorter time for enablement, thereby allowing at least two of the plurality of functions to share a common driver output enabling signal.