Abstract: An electrified powertrain that generates and transfers drive torque to a driveline of an electrified vehicle includes an electric motor, a driver interface and a controller. The driver interface has an accelerator pedal and a human machine interface that communicates a signal indicative of activating a torque-boost mode. The controller controls torque delivery based on an accelerator pedal map, the accelerator pedal map having (i) a first torque trace providing a maximum torque output based on a position of the accelerator pedal, and (ii) a second torque trace indicative of the torque-boost mode and providing a maximum torque-boost output based on the position of the accelerator pedal, the maximum torque-boost output being greater than the maximum torque output, wherein the controller commands the electric motor to operate at the maximum torque-boost output based on a driver activation input and a determination that the electrified vehicle is in motion.

Abstract: The present invention relates to pseudotyped lentiviral vectors, particularly to pseudotyped with a modified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, as well as related constructs, methods and therapeutic indications.

Abstract: An electrified powertrain that generates and transfers drive torque to a driveline of an electrified vehicle includes an electric motor, a driver interface and a controller. The driver interface has an accelerator pedal and a human machine interface that communicates a signal indicative of activating a torque-boost mode. The controller controls torque delivery based on an accelerator pedal map, the accelerator pedal map having (i) a first torque trace providing a maximum torque output based on a position of the accelerator pedal, and (ii) a second torque trace indicative of the torque-boost mode and providing a maximum torque-boost output based on the position of the accelerator pedal, the maximum torque-boost output being greater than the maximum torque output, wherein the controller commands the electric motor to operate at the maximum torque-boost output based on a driver activation input and a determination that the electrified vehicle is in motion.

Abstract: The present invention provides methods of preparing pyrimidine cyclohexyl glucocorticoid receptor modulators, methods of preparing intermediates of pyrimidine cyclohexyl glucocorticoid receptor modulators, and pyridinium compounds.

Abstract: The present invention provides methods of preparing pyrimidine cyclohexyl glucocorticoid receptor modulators, methods of preparing intermediates of pyrimidine cyclohexyl glucocorticoid receptor modulators, and thioether compounds.

Abstract: A promoter for high level and sustained expression is provided which can be used for gene expression of chosen sequences in general. In particular, a nucleic acid construct comprising a hCEF1 promoter operably linked to a sequence for expression is provided, where the hCEF1 promoter comprises: (i) a human CMV enhancer operably linked to a human EFI a promoter; (ii) a functional fragment of (i); or (ii) a functional variant of (i) or (ii).

Abstract: A promoter for high level and sustained expression is provided which can be used for gene expression of chosen sequences in general. In particular, a nucleic acid construct comprising a hCEF1 promoter operably linked to a sequence for expression is provided, where the hCEF1 promoter comprises: (i) a human CMV enhancer operably linked to a human EFI a promoter; (ii) a functional fragment of (i); or (ii) a functional variant of (i) or (ii).

Abstract: A promoter for high level and sustained expression is provided which can be used for gene expression of chosen sequences in general. In particular, a nucleic acid construct comprising a hCEF1 promoter operably linked to a sequence for expression is provided, where the hCEF1 promoter comprises: (i) a human CMV enhancer operably linked to a human EF1 a promoter; (ii) a functional fragment of (i); or (ii) a functional variant of (i) or (ii).

Abstract: The present invention relates to medicaments for the treatment of cystic fibrosis. Also provided are methods of preparing such medicaments so that they can be used in a treatment regime for cystic fibrosis. The present invention also provides a kit of parts including the medicament of the invention, as well as treatment regimes for cystic fibrosis.

Abstract: A promoter for high level and sustained expression is provided which can be used for gene expression of chosen sequences in general. In particular, a nucleic acid construct comprising a hCEF1 promoter operably linked to a sequence for expression is provided, where the hCEF1 promoter comprises: (i) a human CMV enhancer operably linked to a human EF1 a promoter; (ii) a functional fragment of (i); or (ii) a functional variant of (i) or (ii).

Abstract: An electronic drive system using a plurality of drive circuits for enabling greater plurality of functions by selectively placing drive signals on the driver outputs at one of two possible polarities. At least one of the enabled functions taking a substantially shorter time for enablement, thereby allowing at least two of the plurality of functions to share a common driver output enabling signal.