Patents by Inventor Stephen J. Bigus

Stephen J. Bigus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6656517
    Abstract: A method of providing a therapeutic, diagnostic or lubricious hydrophilic coating on an intracorporeal medical device and the coated device produced thereby, wherein the coating is durable. In one embodiment, the coating comprises a polymerized base coat and a therapeutic, diagnostic or hydrophilic top coat, where the base coat has a binding component which binds to the top coat, and a grafting component which binds to the binding component and adheres to the device. In another embodiment, the coating comprises a blend of a hydrophilic compound, a grafting component, and salt, wherein the polymerized grafting component contains uncrosslinked domains. The coating of the invention may be applied to a medical device with a polymeric surface such as a polymeric catheter, or a metal device coated with a polymeric primer or without a primer, or to a stent.
    Type: Grant
    Filed: July 25, 2001
    Date of Patent: December 2, 2003
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Eugene T. Michal, Christopher J. Buchko, Stephen J. Bigus
  • Patent number: 6544219
    Abstract: The catheter assembly includes an expandable member mounted to the distal end of a placement catheter, for delivery of a therapeutic device in one of the branch vessels of a bifurcated vessel. The catheter assembly includes lumens for a tracking guide wire and a positioning guide member for placement of the therapeutic device. The therapeutic device is mounted on the expandable member, the tracking guide wire is placed into the target branch vessel, and the placement catheter is then introduced over the tracking guide wire. A positioning guide member is introduced through the catheter, extended through an exit port in the catheter proximal to the expandable member, and then placed in another branch vessel of the bifurcation. The placement catheter then is advanced until the positioning guide member engages the vessel carina between the branch vessels, and the therapeutic device then may be placed accurately in the target branch vessel.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: April 8, 2003
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Dorrie M. Happ, Virgilda Torate, Stephen J. Bigus
  • Patent number: 6541116
    Abstract: A method of providing a therapeutic, diagnostic or lubricious hydrophilic coating on an intracorporeal medical device and the coated device produced thereby, wherein the coating is durable. In one embodiment, the coating comprises a polymerized base coat and a top coat having a therapeutic, diagnostic or hydrophilic agent, where the base coat has a binding component which binds to the top coat, and a grafting component which binds to the binding component and adheres to the device. In another embodiment, the coating comprises a blend of an agent, a grafting component, and salt. In one embodiment, the therapeutic agent is superoxide dismutase or a superoxide dismutase mimic. The coating of the invention may be applied to a medical device with a polymeric surface such as a polymeric catheter, or a metal device such as a stent coated with a polymeric primer or without a primer.
    Type: Grant
    Filed: April 6, 2001
    Date of Patent: April 1, 2003
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Eugene T. Michal, Christopher J. Buchko, Deborah L. Kilpatrick, Stephen J. Bigus
  • Patent number: 6540719
    Abstract: An intraluminal catheter having a catheter shaft and distal member rotatable relative to at least a section of the catheter shaft. In one embodiment, the catheter has a catheter shaft, a distal member, which in a presently preferred embodiment is a balloon mounted on a distal portion of the shaft, and a tubular sealing member having an expandable portion disposed at least in part within a section of the distal member. The tubular sealing member has an expanded configuration, and an unexpanded configuration expandable into contact with the section of the distal member, so that the distal member is rotatable relative to at least a section of the catheter shaft and to the tubular sealing member when the tubular sealing member is in the unexpanded configuration.
    Type: Grant
    Filed: December 8, 2000
    Date of Patent: April 1, 2003
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Stephen J. Bigus, Phebe T. Cababaro, Steven B. Choi
  • Publication number: 20020077591
    Abstract: The catheter assembly includes an expandable member mounted to the distal end of a placement catheter, for delivery of a therapeutic device in one of the branch vessels of a bifurcated vessel. The catheter assembly includes lumens for a tracking guide wire and a positioning guide member for placement of the therapeutic device. The therapeutic device is mounted on the expandable member, the tracking guide wire is placed into the target branch vessel, and the placement catheter is then introduced over the tracking guide wire. A positioning guide member is introduced through the catheter, extended through an exit port in the catheter proximal to the expandable member, and then placed in another branch vessel of the bifurcation. The placement catheter then is advanced until the positioning guide member engages the vessel carina between the branch vessels, and the therapeutic device then may be placed accurately in the target branch vessel.
    Type: Application
    Filed: December 15, 2000
    Publication date: June 20, 2002
    Inventors: Dorrie M. Happ, Virgilda Torate, Stephen J. Bigus
  • Publication number: 20020072755
    Abstract: An intraluminal catheter having a catheter shaft and distal member rotatable relative to at least a section of the catheter shaft. In one embodiment, the catheter has a catheter shaft, a distal member, which in a presently preferred embodiment is a balloon mounted on a distal portion of the shaft, and a tubular sealing member having an expandable portion disposed at least in part within a section of the distal member. The tubular sealing member has an expanded configuration, and an unexpanded configuration expandable into contact with the section of the distal member, so that the distal member is rotatable relative to at least a section of the catheter shaft and to the tubular sealing member when the tubular sealing member is in the unexpanded configuration.
    Type: Application
    Filed: December 8, 2000
    Publication date: June 13, 2002
    Inventors: Stephen J. Bigus, Phebe T. Cababaro, Steven B. Choi
  • Publication number: 20020009535
    Abstract: A method of providing a therapeutic, diagnostic or lubricious hydrophilic coating on an intracorporeal medical device and the coated device produced thereby, wherein the coating is durable. In one embodiment, the coating comprises a polymerized base coat and a top coat having a therapeutic, diagnostic or hydrophilic agent, where the base coat has a binding component which binds to the top coat, and a grafting component which binds to the binding component and adheres to the device. In another embodiment, the coating comprises a blend of an agent, a grafting component, and salt. In one embodiment, the therapeutic agent is superoxide dismutase or a superoxide dismutase mimic. The coating of the invention may be applied to a medical device with a polymeric surface such as a polymeric catheter, or a metal device such as a stent coated with a polymeric primer or without a primer.
    Type: Application
    Filed: April 6, 2001
    Publication date: January 24, 2002
    Applicant: Advanced Cardiovascular Systems, Inc.
    Inventors: Eugene T. Michal, Christopher J. Buchko, Deborah L. Kilpatrick, Stephen J. Bigus
  • Publication number: 20020002353
    Abstract: A method of providing a therapeutic, diagnostic or lubricious hydrophilic coating on an intracorporeal medical device and the coated device produced thereby, wherein the coating is durable. In one embodiment, the coating comprises a polymerized base coat and a therapeutic, diagnostic or hydrophilic top coat, where the base coat has a binding component which binds to the top coat, and a grafting component which binds to the binding component and adheres to the device. In another embodiment, the coating comprises a blend of a hydrophilic compound, a grafting component, and salt, wherein the polymerized grafting component contains uncrosslinked domains. The coating of the invention may be applied to a medical device with a polymeric surface such as a polymeric catheter, or a metal device coated with a polymeric primer or without a primer, or to a stent.
    Type: Application
    Filed: July 25, 2001
    Publication date: January 3, 2002
    Applicant: Advanced Cardiovascular Systems, Inc.
    Inventors: Eugene T. Michal, Christopher J. Buchko, Stephen J. Bigus
  • Patent number: 6287285
    Abstract: A method of providing a therapeutic, diagnostic or lubricious hydrophilic coating on an intracorporeal medical device and the coated device produced thereby, wherein the coating is durable. In one embodiment, the coating comprises a polymerized base coat and a therapeutic, diagnostic or hydrophilic top coat, where the base coat has a binding component which binds to the top coat, and a grafting component which binds to the binding component and adheres to the device. In another embodiment, the coating comprises a blend of a hydrophilic compound, a grafting component, and salt, wherein the polymerized grafting component contains uncrosslinked domains. The coating of the invention may be applied to a medical device with a polymeric surface such as a polymeric catheter, or a metal device coated with a polymeric primer or without a primer, or to a stent.
    Type: Grant
    Filed: January 29, 1999
    Date of Patent: September 11, 2001
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Eugene T. Michal, Christopher J. Buchko, Stephen J. Bigus
  • Patent number: 4916038
    Abstract: A new group of silane compounds in which silicon atoms are linked together by a hydrocarbon chain and which comprise phenyl groups substituted with an epoxy group or an ethenyl group. The compounds of the present invention have the formula ##STR1## where R.sub.1 is selected from the group consisting of: (a) an aliphatic hydrocarbon group containing 2 to 10 carbon atoms, and(b) a group having the formula ##STR2## where n=1 to 3m=0 to 5;R.sub.2 and R.sub.2 ' are each selected from the group consisting of an alkyl group containing 1 to 4 carbon atoms, an unsubstituted aryl group, and a substituted aryl group; and R.sub.3 is selected from the group consisting of: ##STR3## where R.sub.4, R.sub.5, and R.sub.6 ae each selected from the group consisting of H, an alkyl group containing 1 to 4 carbon atoms, and an aryl group; and n=0 to 10.
    Type: Grant
    Filed: August 29, 1988
    Date of Patent: April 10, 1990
    Assignee: Hughes Aircraft Company
    Inventors: Kreisler S. Y. Lau, Susan L. Oldham, William E. Elias, Stephen J. Bigus
  • Patent number: 4874643
    Abstract: A method for rendering a substrate resistant to erosion by a plasma comprising oxygen by providing on the surface of the substrate a layer of a cured polymer of a compound having the formula ##STR1## where: R.sub.1 is selected from the group consisting of:(a) an aliphatic hydrocarbon group containing 2 to 10 carbon atoms, and(b) a group having the formula ##STR2## wherein n=1 to 3 m=0 to 5R.sub.2 and R.sub.2 ' are each selected from the group consisting of an alkyl group containing 1 to 4 carbon atoms, an unsubstituted aryl group, and a substituted aryl group; and R.sub.
    Type: Grant
    Filed: July 13, 1988
    Date of Patent: October 17, 1989
    Assignee: Hughes Aircraft Company
    Inventors: Susan L. Oldham, William E. Elias, Stephen J. Bigus, Kreisler S. Y. Lau
  • Patent number: 4861901
    Abstract: A new group of silane compounds in which silicon atoms are linked together by a hydrocarbon chain and which comprise phenyl groups substituted with an epoxy group or an ethenyl group. The compounds of the present invention have the formula ##STR1## where R.sub.1 is selected from the group consisting of:(a) an aliphatic hydrocarbon group containing 2 to 10 carbon atoms, and(b) a group having the formula ##STR2## where n=1 to 3m=0 to 5;R.sub.2 and R.sub.2 ' are each selected from the group consisting of an alkyl group containing 1 to 4 carbon atoms, an unsubstituted aryl group, and a substituted aryl group;and R.sub.3 is selected from the group consisting of: ##STR3## where R.sub.4, R.sub.5, and R.sub.6 are each selected from the group consisting of H, an alkyl group containing 1 to 4 carbon atoms, and an aryl group; and n=0 to 10.
    Type: Grant
    Filed: May 5, 1987
    Date of Patent: August 29, 1989
    Assignee: Hughes Aircraft Company
    Inventors: Kreisler S. Y. Lau, Susan L. Oldham, William E. Elias, Stephen J. Bigus