Patents by Inventor Stephen J. Box

Stephen J. Box has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • .beta.-Lactam antibiotic, its preparation and use
    Patent number: 4421760
    Abstract: The compound of the formula (VI): ##STR1## pharmaceutically acceptable salts and pharmaceutically acceptable esters thereof, are useful for their antibacterial activity and for their .beta.-lactamase inhibitory activity. They may be combined in a synergistically effective amount with a penicillin or cephalosporin for the treatment of bacterial infections in humans and animals.
    Type: Grant
    Filed: June 17, 1981
    Date of Patent: December 20, 1983
    Assignee: Beecham Group Limited
    Inventor: Stephen J. Box
  • Streptomycetal antibiotic
    Patent number: 4261977
    Abstract: A novel antibiotic designated herein MM 17880 may be obtained from the cultivation of strains of Streptomyces olivaceus and related organisms. In addition to being potent antibacterial agents, MM 17880 and its salts inhibit .beta.-lactamase obtained from many organisms so that it shows a synergistic antibacterical effect when combined with .beta.-lactam antibiotics.
    Type: Grant
    Filed: August 29, 1978
    Date of Patent: April 14, 1981
    Assignee: Beecham Group Limited
    Inventors: Stephen J. Box, John D. Hood
  • Process for producing antibiotics
    Patent number: 4221870
    Abstract: This invention provides a process for the preparation of salts of the .beta.-lactamase inhibitory antibiotics MM4550A, MM13902 and MM17880, which are the compounds of the formulae (I)-(III), respectively: ##STR1## which process comprises cultivating a strain of Streptomyces gedanensis and isolating a salt of at least one of MM4550A, MM13902 and MM17880.
    Type: Grant
    Filed: June 19, 1978
    Date of Patent: September 9, 1980
    Assignee: Beecham Group Limited
    Inventor: Stephen J. Box
  • Streptomycetal antibiotic
    Patent number: 4179498
    Abstract: A novel antibiotic designated herein MM 17880 may be obtained from the cultivation of strains of Streptomyces olivaceus and related organisms. In addition to being potent antibacterial agents, MM 17880 and its salts inhibit .beta.-lactamase obtained from many organisms so that it shows a synergistic antibacterial effect when combined with .beta.-lactam antibiotics.
    Type: Grant
    Filed: August 24, 1976
    Date of Patent: December 18, 1979
    Assignee: Beecham Group Limited
    Inventors: Stephen J. Box, John D. Hood
  • Streptomycetal antibiotic
    Patent number: 4163051
    Abstract: A novel antibiotic designated herein MM 17880 may be obtained from the cultivation of strains of Streptomyces olivaceus and related organisms. In addition to being potent antibacterial agents, MM 17880 and its salts inhibit .beta.-lactamase obtained from may organisms so that it shows a synergistic antibacterial effect when combined with .beta.-lactam antibiotics.
    Type: Grant
    Filed: September 23, 1976
    Date of Patent: July 31, 1979
    Assignee: Beecham Group Limited
    Inventors: Stephen J. Box, John D. Hood
  • Streptomycetal antibiotic
    Patent number: 4162304
    Abstract: A novel antibiotic designated herein MM 17880 may be obtained from the cultivation of strains of Streptomyces olivaceus and related organisms. In addition to being potent antibacterial agents, MM 17880 and its salts inhibit .beta.-lactamase obtained fromm many organisms so that it shows a synergistic antibacterial effect when combined with .beta.-lactam antibiotics.
    Type: Grant
    Filed: September 22, 1976
    Date of Patent: July 24, 1979
    Assignee: Beecham Group Limited
    Inventors: Stephen J. Box, John D. Hood
  • Preparation of clavulanic using Streptomyces jumonjinensis
    Patent number: 4072569
    Abstract: Clavulanic acid and its salts may be produced by cultivating a strain of Streptomyces jumonjinensis.
    Type: Grant
    Filed: September 24, 1976
    Date of Patent: February 7, 1978
    Assignee: Beecham Group Limited
    Inventor: Stephen J. Box