Patents by Inventor Stephen J. Brocchini

Stephen J. Brocchini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Degradable polyacetal polymers
    Patent number: 7220414
    Abstract: Degradable polyacetal polymers and functionalized degradable polyacetal polymers have properties favorable for use in pharmaceutical and biomedical applications. The degradable polyacetal polymers are relatively stable at physiological pH with favorable biodistribution profiles, and degrade readily in low pH conditions. Conjugates of the polymers with drugs, especially anticancer drugs, and methods of treatment of cancer.
    Type: Grant
    Filed: September 6, 2001
    Date of Patent: May 22, 2007
    Assignee: A.P. Pharma, Inc.
    Inventors: Stephen J. Brocchini, Jorge Heller, Ryan Tomlinson, Ruth Duncan, Shane Garrett, Marcus M. Klee
  • Degradable polyacetal polymers
    Publication number: 20020082362
    Abstract: Degradable polyacetal polymers and functionalized degradable polyacetal polymers have properties favorable for use in pharmaceutical and biomedical applications. The degradable polyacetal polymers are relatively stable at physiological pH with favorable biodistribution profiles, and degrade readily in low pH conditions. Conjugates of the polymers with drugs, especially anticancer drugs, and methods of treatment of cancer.
    Type: Application
    Filed: September 6, 2001
    Publication date: June 27, 2002
    Inventors: Stephen J. Brocchini, Jorge Heller, Ryan Tomlinson, Ruth Duncan, Shane Garrett, Marcus M. Klee
  • Pharmaceutical piperazine compounds
    Patent number: 5935955
    Abstract: A piperazinedione of general formula (I): ##STR1## wherein R.sup.1 is selected from hydrogen;a group of formula --(NH).sub.t --COR.sup.3 wherein t is 0 or 1 and R.sup.3 is an organic substituent as defined herein;a group of formula (D): ##STR2## and a group of formula (E): ##STR3## and the pharmaceutically acceptable salts thereof are useful as modulators of multi-drug resistance.
    Type: Grant
    Filed: August 29, 1997
    Date of Patent: August 10, 1999
    Assignee: Xenova Limited
    Inventors: Philip A. Ashworth, Sukhjit Hunjan, Ian A. Pretswell, Harnish Ryder, Stephen J. Brocchini
  • Synthesis of tyrosine-derived diphenol monomers
    Patent number: 5670602
    Abstract: A method for preparing diphenol compounds, which method includes the steps of coupling a hydroxyphenyl carboxylic acid with a L-tyrosine ester in a water-miscible organic reaction solvent containing a carbodiimide capable of forming a water-soluble urea by-product, thereby forming a diphenol reaction product; and combining the reaction mixture with an amount of water effective to precipitate the diphenol as a water-immiscible organic phase, so that a water-immiscible organic phase is formed containing the diphenol reaction product. New diphenol monomers and polymers polymerized therefrom are also disclosed.
    Type: Grant
    Filed: March 29, 1996
    Date of Patent: September 23, 1997
    Assignee: Rutgers, The State University
    Inventors: Joachim B. Kohn, Stephen J. Brocchini, Arthur L. Schwartz