Abstract: A serial-flow filtration device is provided with pressure-activated means for by-passing at least one of its constituent layer (or layers) of filtration material. The filtration device comprises a housing, a fluid inlet, a fluid outlet, and at least an upper and a rearmost filter layer. The upper filter layer divides the interior of the housing into an upstream zone and a downstream zone, with the rearmost filter layer residing in the downstream zone. The fluid inlet enables the introduction of fluid into said upstream zone. The fluid outlet enables releases of the fluid from said downstream zone. The upper filter layer, but not the rearmost filter layer, has integrated thereinto a pressure-activated means capable of allowing substantially non-selective passage of fluid from the upstream zone into the downstream zone upon the attainment of a predetermined pressure differential across said upper filter layer.

Abstract: A manifold adaptor plate useful as a gasket having liquid pathways which permit passing of a filtrate, a feed and a retentate wherein admixture of the filtrate with the feed or the retentate is prevented is provided and is formed of an elastomeric layer, a rigid intermediate layer and a polymer layer. The elastomeric layer functions as a gasket and is bonded to the polymeric layer through the liquid pathways of the intermediate plate. An elastomer layer may be formed on both layers as well and optionally a second polymer layer between the intermediate layer and the second elastomer layer may also be used.

Abstract: A serial-flow filtration device is provided with pressure-activated pressure-breachable seal or a pressure-activated gate for by-passing at least one of its constituent layer (or layers) of filtration material. The filtration device comprises a housing, a fluid inlet, a fluid outlet, and at least an upper and a rearmost filter layer. The upper filter layer divides the interior of the housing into an upstream zone and a downstream zone, with the rearmost filter layer residing in the downstream zone. The fluid inlet enables the introduction of fluid into said upstream zone. The fluid outlet enables releases of the fluid from said downstream zone. The upper filter layer, but not the rearmost filter layer, has integrated thereinto a pressure-activated pressure-breachable seal or a pressure-activated gate capable of allowing substantially non-selective passage of fluid from the upstream zone into the downstream zone upon the attainment of a predetermined pressure differential across said upper filter layer.

Abstract: A manifold adaptor plate useful as a gasket having liquid pathways which permit passing of a filtrate, a feed and a retentate wherein admixture of the filtrate with the feed or the retentate is prevented is provided and is formed of an elastomeric layer, a rigid intermediate layer and a polymer layer. The elastomeric layer functions as a gasket and is bonded to the polymeric layer through the liquid pathways of the intermediate plate. An elastomer layer may be formed on both layers as well and optionally a second polymer layer between the intermediate layer and the second elastomer layer may also be used.

Abstract: A serial-flow filtration device is provided with pressure-activated means for by-passing at least one of its constituent layer (or layers) of filtration material. The filtration device comprises a housing, a fluid inlet, a fluid outlet, and at least an upper and a rearmost filter layer. The upper filter layer divides the interior of the housing into an upstream zone and a downstream zone, with the rearmost filter layer residing in the downstream zone. The fluid inlet enables the introduction of fluid into said upstream zone. The fluid outlet enables releases of the fluid from said downstream zone. The upper filter layer, but not the rearmost filter layer, has integrated thereinto a pressure-activated means capable of allowing substantially non-selective passage of fluid from the upstream zone into the downstream zone upon the attainment of a predetermined pressure differential across said upper filter layer.

Abstract: A serial-flow filtration device includes a pressure-activated gate for by-passing at least one of its constituent layer (or layers) of filtration material. The filtration device includes a housing, a fluid inlet, a fluid outlet, and at least an upper and a rearmost filter layer. The upper filter layer divides the interior of the housing into an upstream zone and a downstream zone, with the rearmost filter layer residing in the downstream zone. The fluid inlet enables the introduction of fluid into the upstream zone. The fluid outlet enables releases of the fluid from the downstream zone. The upper filter layer, but not the rearmost filter layer, has integrated thereinto a pressure-activated gate capable of allowing substantially non-selective passage of fluid from the upstream zone into the downstream zone upon the attainment of a predetermined pressure differential across upper filter layer.

Abstract: A serial-flow filtration device is provided with pressure-activated means for by-passing at least one of its constituent layer (or layers) of filtration material. The filtration device comprises a housing, a fluid inlet, a fluid outlet, and at least an upper and a rearmost filter layer. The upper filter layer divides the interior of the housing into an upstream zone and a downstream zone, with the rearmost filter layer residing in the downstream zone. The fluid inlet enables the introduction of fluid into said upstream zone. The fluid outlet enables releases of the fluid from said downstream zone. The upper filter layer, but not the rearmost filter layer, has integrated thereinto a pressure-activated means capable of allowing substantially non-selective passage of fluid from the upstream zone into the downstream zone upon the attainment of a predetermined pressure differential across said upper filter layer.