Patents by Inventor Stephen J. Gardell

Stephen J. Gardell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gamma three protease
    Patent number: 7135307
    Abstract: Gamma three protease is provided, a novel aspartyl class protease that is capable of taking part in the processing of amyloid precursor protein (APP) to A? peptide. Gamma three protease may be involved in the development and/or progression of Alzheimers disease. Methods of identifying inhibitors of gamma three protease, useful in the prevention or treatment of Alzheimers disease, are disclosed.
    Type: Grant
    Filed: August 8, 2002
    Date of Patent: November 14, 2006
    Assignee: Merck & Co., Inc.
    Inventors: Ming-Chih Crouthamel, Stephen J. Gardell, Qian Huang, Ming-Tain Lai, Yueming Li
  • Investigational compounds
    Patent number: 6753410
    Abstract: The present invention is directed to compounds and pharmaceutical compositions comprising the compounds which are inhibitors of the enzyme gamma secretase and which are useful in the treatment or prevention of diseases in which the beta-amyloid peptide is involved, such as Alzheimer's disease.
    Type: Grant
    Filed: March 2, 2001
    Date of Patent: June 22, 2004
    Assignee: Merck & Co., Inc.
    Inventors: Alan John Nadin, Joseph George Neduvelil, Mohinder K. Sardana, Jules A. Shafer, Stephen J. Gardell, Ming-Tain Lai, Yueming Li, Bruce D. Dorsey, Dennis C. Dean
  • Gamma secretase substrates and in vitro assays
    Publication number: 20030215896
    Abstract: The present invention features &ggr;-secretase substrates and in vitro assays for measuring &ggr;-secretase activity employing such substrates. The &ggr;-secretase substrates described herein contain a hydrophilic polypeptide moiety covalently joined to the carboxyl terminus of a &bgr;-CTF domain. A “&bgr;-CTF domain” is a polypeptide that can be cleaved by &ggr;-secretase and which approximates the C-terminal fragment (amino acids 596-695) of APP produced after cleavage of APP by a &bgr;-secretase, or is a functional derivative thereof.
    Type: Application
    Filed: January 17, 2003
    Publication date: November 20, 2003
    Inventors: Yueming Li, Min Xu, Qian Huang, Stephen J Gardell
  • Methods for treating or reducing the risk of pain and inflammatory disorders by administering inhibitors of activated thrombin activatable fibrinolysis inhibitor
    Publication number: 20030035795
    Abstract: The invention includes methods for treating or reducing the risk of inflammation in a patient which comprises treating the patient with an inhibitor of activated thrombin activatable fibrinolysis inhibitor. Such diseases include but are not limited to nephritis, systemic lupus erythematosus, rheumatoid arthritis, glomerulonephritis, and sacoidosis. The invention includes methods for treating or reducing the risk of pain in a patient which comprises treating the patient with an inhibitor of activated thrombin activatable fibrinolysis inhibitor.
    Type: Application
    Filed: April 11, 2002
    Publication date: February 20, 2003
    Inventors: Stephen J. Gardell, Shi-Shan Mao
  • Investigational compounds
    Publication number: 20020013276
    Abstract: The present invention provides a compound of formula I or a salt thereof: 1
    Type: Application
    Filed: March 2, 2001
    Publication date: January 31, 2002
    Inventors: Alan John Nadin, Joseph George Neduvelil, Mohinder K. Sardana, Jules A. Shafer, Stephen J. Gardell, Ming-Tain Lai, Yueming Li, Bruce D. Dorsey, Dennis C. Dean
  • Vampire bat salivary plasminogen activators
    Patent number: 5830849
    Abstract: Purified plasminogen activator proteins obtained or derived from the vampire bat Desmodus rotundus saliva and salivary glands, methods for purifying the proteins, DNA sequences encoding these proteins, means for producing them using recombinant DNA technology, pharmaceutical compositions comprising these proteins and methods of treatment utilizing these proteins are provided.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 3, 1998
    Assignee: Schering Aktiengesellschaft
    Inventors: Richard A. F. Dixon, Stephen J. Gardell, Le Thi Duong, Paul A. Friedman, John W. Jacobs, George E. Mark, Bruce L. Daugherty