Patents by Inventor Stephen J. Herman

Stephen J. Herman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190175505
    Abstract: The present invention provides methods for delivery of therapeutic agents to a subject using multi-component liposomal systems. The methods include administration of a therapeutic liposome containing an active agent, followed by a administration of an attacking liposome that induces release of the agents from the therapeutic liposome.
    Type: Application
    Filed: February 19, 2019
    Publication date: June 13, 2019
    Inventors: Jun Yang, Stephen H. Wu, Cliff J. Herman
  • Patent number: 8834358
    Abstract: A cannula assembly includes a tubular element forming a lumen, a deployable element of a subassembly, and an electronic component mounted to the deployable element. The tubular element has a proximal end and a distal end adapted to be inserted into a body cavity. The deployable element is coupled through the subassembly to the tubular element, and is adapted to transition between a closed position and an open position. The electronic component has at least one imaging device and at least one illumination source. The subassembly, including the deployable element and the electronic component, are releasable from the tubular element.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: September 16, 2014
    Assignee: EndoSphere Surgical, Inc.
    Inventors: Arthur C. Mckinley, Jesse R. Plouffe, Melvin B. Prenovitz, Stephen J. Herman, Vivek Sikri
  • Publication number: 20140107417
    Abstract: A cannula assembly includes a tubular element forming a lumen, a deployable element of a subassembly, and an electronic component mounted to the deployable element. The tubular element has a proximal end and a distal end adapted to be inserted into a body cavity. The deployable element is coupled through the subassembly to the tubular element, and is adapted to transition between a closed position and an open position. The electronic component has at least one imaging device and at least one illumination source. The subassembly, including the deployable element and the electronic component, are releasable from the tubular element.
    Type: Application
    Filed: March 15, 2013
    Publication date: April 17, 2014
    Applicant: EndoSphere Surgical, Inc.
    Inventors: Arthur C. McKinley, Jesse R. Plouffe, Melvin B. Prenovitz, Stephen J. Herman, Vivek Sikri
  • Publication number: 20130197932
    Abstract: Systems and methods are provided for providing decision making support in healthcare. A user is able to provide healthcare data, including qualifier, indications, body part modifiers, body parts, modality modifiers, modalities, procedures and protocols. A graphical user interface (GUI) is provided to allow procedure rules to be created by selecting components of the healthcare data. The procedure rules identify and recommend appropriate procedures based on user input. The GUI also allows for global rules, body part rules, modality rules and modality modifier rules to be created; these rules are contra-indicators to procedures. Upon establishing the rules, a physician can enter data about a patient into the system, and the system will use the rules to return one or more appropriate procedures.
    Type: Application
    Filed: September 24, 2010
    Publication date: August 1, 2013
    Applicant: MEDCURRENT CORPORATION
    Inventors: Stephen J. Herman, Priyanga Manoharan, David Judd
  • Patent number: 8308707
    Abstract: Methods and systems are provided for delivering drug to the eye. The method and system may include implanting into the eye a device which comprises two or more discrete reservoirs, each reservoir containing a drug; and directing focused light to the implanted device to open a first one of the reservoirs and thereby permit the drug to diffuse from the first reservoir to the patient's eye.
    Type: Grant
    Filed: January 24, 2011
    Date of Patent: November 13, 2012
    Assignee: MicroCHIPS, Inc.
    Inventors: John T. Santini, Jr., Michael J. Cima, Robert S. Langer, Dennis Ausiello, Norman F. Sheppard, Jr., Stephen J. Herman
  • Patent number: 8277440
    Abstract: Method and devices are provided for extended and controlled delivery of parathyroid hormone to a patient. The method includes implanting a medical device into the patient, the medical device comprising a substrate, a plurality of reservoirs in the substrate, a release system contained in each of the reservoirs, wherein the release system comprises parathyroid hormone; and controllably releasing a pharmaceutically effective amount of the parathyroid hormone from the reservoirs. The parathyroid hormone can be released intermittently, such as once daily over an extended period (e.g., two months, ten months, or more.). The device can further include reservoirs containing a bone resorption inhibitor or other drug for release. The devices are useful in delivering PTH for the treatment and prevention of bone loss, such as associated with osteoporosis.
    Type: Grant
    Filed: January 23, 2009
    Date of Patent: October 2, 2012
    Assignee: MicroCHIPS, Inc.
    Inventors: Dennis Ausiello, John T. Santini, Jr., Stephen J. Herman, James H. Prescott, Scott A. Uhland, John M. Maloney, Benjamin F. Polito
  • Patent number: 8211092
    Abstract: Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a substrate, a plurality of reservoirs in the substrate, reservoir contents disposed in the reservoirs, discrete reservoir caps covering each reservoir to seal the reservoir contents in the reservoirs, and control circuitry for selectively disintegrating the reservoir caps to release or expose the reservoir contents in vivo. At least one of the reservoir caps comprises a first electrically conductive layer coated with one or more protective layers. In one embodiment, the control circuitry comprises an electrical input lead and an electrical output lead connected to and directly contacting each of said reservoir caps and a source of electric power for applying an electrical current through each reservoir cap in an amount effective to rupture each of the reservoir caps.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: July 3, 2012
    Assignee: MicroCHIPS, Inc.
    Inventors: Scott A. Uhland, Benjamin F. Polito, John M. Maloney, Norman F. Sheppard, Jr., Stephen J. Herman, Barry M. Yomtov
  • Patent number: 8095197
    Abstract: Medical devices, utilizing multiple reservoirs to protect and selectively expose sensors or other reservoir contents, are provided having (i) a reservoir contents destruction mechanism to interrupt the release or exposure of reservoir contents, for example, to deactivate an unneeded sensor and prevent it from negatively impacting other sensors, (ii) a protective covering material layer over the sensor underneath the reservoir cap, which protects the sensor membrane and sensor during reservoir cap disintegration and then is removed, (iii) a device design for containing sensors in shallow, wide reservoir structures to enhance sensor exposure by minimizing molecular diffusion distances, (iv) an implantable sensor unit and a separate drug delivery unit, or (v) combinations thereof.
    Type: Grant
    Filed: November 3, 2004
    Date of Patent: January 10, 2012
    Assignee: MicroCHIPS, Inc.
    Inventors: John T. Santini, Jr., Stephen J. Herman
  • Publication number: 20110172587
    Abstract: Methods and systems are provided for delivering drug to the eye. The method and system may include implanting into the eye a device which comprises two or more discrete reservoirs, each reservoir containing a drug; and directing focused light to the implanted device to open a first one of the reservoirs and thereby permit the drug to diffuse from the first reservoir to the patient's eye.
    Type: Application
    Filed: January 24, 2011
    Publication date: July 14, 2011
    Applicant: MICROCHIPS, INC.
    Inventors: John T. Santini, JR., Michael J. Cima, Robert S. Langer, Dennis Ausiello, Norman F. Sheppard, JR., Stephen J. Herman
  • Patent number: 7917208
    Abstract: Medical device and methods are provided for controlled drug delivery in a cardiac patient. The device includes an implantable drug delivery module comprising reservoirs containing a drug and a control means for selectively releasing an effective amount of drug from each reservoir; one or more electrodes or sensors for cardiac monitoring, stimulation, or both; and a microcontroller for controlling operational interaction of the drug delivery module and the cardiac electrode. The electrodes may comprise ECG monitoring, cardioversion, or cardiac pacing electrodes.
    Type: Grant
    Filed: October 6, 2003
    Date of Patent: March 29, 2011
    Assignee: MicroCHIPS, Inc.
    Inventors: Barry M. Yomtov, Stephen J. Herman
  • Patent number: 7910151
    Abstract: Devices and methods for the controlled release or exposure of reservoir contents, and methods of manufacture thereof, are provided. The device includes a reservoir cap formed of an electrically conductive material, which prevents the reservoir contents from passing out from the device and prevents exposure of the reservoir contents to molecules outside of the device; an electrical input lead connected to said reservoir cap; and an electrical output lead connected to said reservoir cap, such that upon application of an electrical current through the reservoir cap, via the input lead and output lead, the reservoir cap ruptures to release or expose the reservoir contents. The reservoir contents can comprise a release system containing drug molecules for release or can comprise a secondary device, such as a sensor. The controlled release system may be incorporated into an implantable drug delivery or biosensing device.
    Type: Grant
    Filed: October 27, 2005
    Date of Patent: March 22, 2011
    Assignee: MicroCHIPS, Inc.
    Inventors: Scott A. Uhland, Benjamin F. Polito, John M. Maloney, Norman F. Sheppard, Jr., Stephen J. Herman, Barry Y. Yomtov
  • Publication number: 20100023071
    Abstract: Medical devices and methods are provided for electrical stimulation of neural tissue and controlled drug delivery to a patient. The device includes an implantable drug delivery module which comprises a plurality of reservoirs, a release system comprising at least one drug contained in each of the reservoirs, and control means for selectively releasing a pharmaceutically effective amount of drug from each reservoir; a neural electrical stimulator which comprises a signal generator connected to at least one stimulation electrode for operable engagement with a neural tissue of the patient; and at least one microcontroller for controlling operational interaction of the drug delivery module and the neural electrical stimulator. The microcontroller may control the signal generator and the control means of the drug delivery module. The device may further include a sensor operable to deliver a signal to the microcontroller, for example to indicate when to deliver electrical stimulation, drug, or both.
    Type: Application
    Filed: October 2, 2009
    Publication date: January 28, 2010
    Applicant: MICROCHIPS, INC.
    Inventors: Barry M. Yomtov, Stephen J. Herman, John T. Santini, JR.
  • Patent number: 7599737
    Abstract: Medical devices and methods are provided for electrical stimulation of neural tissue and controlled drug delivery to a patient. The device includes an implantable drug delivery module which comprises a plurality of reservoirs, a release system comprising at least one drug contained in each of the reservoirs, and control means for selectively releasing a pharmaceutically effective amount of drug from each reservoir; a neural electrical stimulator which comprises a signal generator connected to at least one stimulation electrode for operable engagement with a neural tissue of the patient; and at least one microcontroller for controlling operational interaction of the drug delivery module and the neural electrical stimulator. The microcontroller may control the signal generator and the control means of the drug delivery module. The device may further include a sensor operable to deliver a signal to the microcontroller, for example to indicate when to deliver electrical stimulation, drug, or both.
    Type: Grant
    Filed: October 6, 2003
    Date of Patent: October 6, 2009
    Assignee: MicroCHIPS, Inc.
    Inventors: Barry M. Yomtov, Stephen J. Herman, John T. Santini, Jr.
  • Publication number: 20090234214
    Abstract: Devices and methods are provided for transdermal diagnostic sensing, alone or in combination with transdermal drug delivery. The device includes a substrate having a plurality of discrete reservoirs, each reservoir having at least one opening; contents disposed in the reservoirs, the contents of each reservoir including a diagnostic agent or a sensor for measuring an analyte; at least one discrete reservoir cap which cover said at least one opening; control means for disintegrating or permeabilizing the reservoir cap; means for transporting an analyte from the skin to said sensors and/or for transporting said diagnostic agent to the skin following release of said diagnostic agents from said reservoir; and means for securing the device to the skin of a patient.
    Type: Application
    Filed: May 26, 2009
    Publication date: September 17, 2009
    Applicant: MICROCHIPS, INC.
    Inventors: John T. Santini, JR., Mark A. Staples, Stephen J. Herman
  • Patent number: 7582080
    Abstract: A drug delivery device for implantation into a patient is provided that includes at least one device element that includes a substrate having a plurality of discrete reservoirs disposed therein, the reservoirs containing drug molecules and a degradable matrix material which controls in vivo release of the drug molecules from the reservoirs, wherein the drug delivery device is adapted to conform to a curved bone tissue surface. In one embodiment, the substrate is flexible and conforms to a bone tissue surface. In another embodiment, the device has two or more device elements attached to or integral with a flexible supporting layer.
    Type: Grant
    Filed: December 1, 2005
    Date of Patent: September 1, 2009
    Assignee: MicroCHIPS, Inc.
    Inventors: John T. Santini, Jr., Michael J. Cima, Norman F. Sheppard, Jr., Stephen J. Herman
  • Publication number: 20090163895
    Abstract: Method and devices are provided for extended and controlled delivery of parathyroid hormone to a patient. The method includes implanting a medical device into the patient, the medical device comprising a substrate, a plurality of reservoirs in the substrate, a release system contained in each of the reservoirs, wherein the release system comprises parathyroid hormone; and controllably releasing a pharmaceutically effective amount of the parathyroid hormone from the reservoirs. The parathyroid hormone can be released intermittently, such as once daily over an extended period (e.g., two months, ten months, or more.). The device can further include reservoirs containing a bone resorption inhibitor or other drug for release. The devices are useful in delivering PTH for the treatment and prevention of bone loss, such as associated with osteoporosis.
    Type: Application
    Filed: January 23, 2009
    Publication date: June 25, 2009
    Applicant: MICROCHIPS, INC.
    Inventors: Dennis Ausiello, John T. Santini, JR., Stephen J. Herman, James H. Prescott, Scott A. Uhland, John M. Maloney, Benjamin F. Polito
  • Patent number: 7537590
    Abstract: Devices and methods are provided for transdermal administration of a pharmaceutical agent to a patient in need thereof. The device includes a substrate, a plurality of discrete reservoirs in the substrate, one or more pharmaceutical agents stored in the reservoirs, discrete reservoir caps that prevent the pharmaceutical agent from passing out from the reservoirs until desired, control means for actuating release of the one or more pharmaceutical agents from one or more of the reservoirs by disintegrating or permeabilizing the reservoir caps, means for securing the device to the skin of the patient, and means for transporting the pharmaceutical agent to the skin following release from the one or more of the reservoirs. In another embodiment, the device is adapted for diagnostic sensing instead of or in addition to drug delivery.
    Type: Grant
    Filed: August 1, 2005
    Date of Patent: May 26, 2009
    Assignee: MicroCHIPS, Inc.
    Inventors: John T. Santini, Jr., Mark A. Staples, Stephen J. Herman
  • Patent number: 7510551
    Abstract: Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a reservoir cap formed of an electrically conductive material, which prevents the reservoir contents from passing out from the device and prevents exposure of the reservoir contents to molecules outside of the device; an electrical input lead connected to said reservoir cap; and an electrical output lead connected to said reservoir cap, such that upon application of an electrical current through the reservoir cap, via the input lead and output lead, the reservoir cap ruptures to release or expose the reservoir contents. The reservoir contents can comprise a release system containing drug molecules for release or can comprise a secondary device, such as a sensor. In one embodiment, the controlled release system is incorporated into an implantable drug delivery device.
    Type: Grant
    Filed: August 15, 2003
    Date of Patent: March 31, 2009
    Assignee: MicroCHIPS, Inc.
    Inventors: Scott A. Uhland, Benjamin F. Polito, John M. Maloney, Norman F. Sheppard, Jr., Stephen J. Herman, Barry Y. Yomtov
  • Patent number: 7497855
    Abstract: Method and devices are provided for extended and controlled delivery of parathyroid hormone to a patient. The method includes implanting a medical device into the patient, the medical device comprising a substrate, a plurality of reservoirs in the substrate, a release system contained in each of the reservoirs, wherein the release system comprises parathyroid hormone; and controllably releasing a pharmaceutically effective amount of the parathyroid hormone from the reservoirs. The parathyroid hormone can be released intermittently, such as once daily over an extended period (e.g., two months, ten months, or more.). The device can further include reservoirs containing a bone resorption inhibitor or other drug for release. The devices are useful in delivering PTH for the treatment and prevention of bone loss, such as associated with osteoporosis.
    Type: Grant
    Filed: September 4, 2003
    Date of Patent: March 3, 2009
    Assignee: MicroCHIPS, Inc.
    Inventors: Dennis Ausiello, John T. Santini, Jr., Stephen J. Herman, James H. Prescott, Scott A. Uhland, John M. Maloney, Benjamin F. Polito
  • Patent number: 7497846
    Abstract: Devices are provided for the controlled exposure or release of contents stored in hermetically sealed reservoirs. The devices comprise a primary substrate having a front side and a back side, and including one or more hermetic sealing materials; a plurality of reservoirs in the primary substrate positioned between the front side and the back side; reservoir contents, which comprise chemical molecules (such as drugs) or a secondary device (such as a glucose sensor), located inside the reservoirs; a hermetic sealing substrate having a surface composed of one or more hermetic sealing materials; and a hermetic seal formed between and joining the primary substrate and the hermetic sealing substrate, wherein the hermetic seal independently seals the reservoirs.
    Type: Grant
    Filed: December 6, 2004
    Date of Patent: March 3, 2009
    Assignee: MicroCHIPS, Inc.
    Inventors: Scott A. Uhland, Benjamin F. Polito, Stephen J. Herman, John T. Santini, Jr., John M. Maloney