Patents by Inventor Stephen J. O'Connor

Stephen J. O'Connor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250072838
    Abstract: Vascular access devices and associated systems and methods are disclosed herein. According to some embodiments, the present technology includes an implantable vascular access device comprising a catheter and a housing defining a fluid reservoir and an outlet port configured to mate with a catheter, the outlet port fluidically coupled to the fluid reservoir. The vascular access device can comprise one or more sensing elements carried by the housing and/or the catheter, which are configured to capture physiological data while the device is implanted within a patient The device can also include a data communications unit configured to receive physiological data from the one or more sensing elements and transmit the physiological data to one or more remote computing devices.
    Type: Application
    Filed: September 20, 2022
    Publication date: March 6, 2025
    Inventors: James D. Mitchell, Andrew A. Thoreson, Lishan Aklog, Brian J. deGuzman, Richard Yazbeck, Stephen J. O'Neill
  • Publication number: 20240268802
    Abstract: A device for collecting a biological sample in a patient, the device includes an expandable member sized for placement within the patient, the expandable member designed to transition between a plurality of states including a collapsed state and a sampling state; a handle in fluid communication with the expandable member; and an indicator configured to identify a status of the expandable member in response to the expandable member transitioning from one state to another.
    Type: Application
    Filed: July 26, 2022
    Publication date: August 15, 2024
    Inventors: Michael Boutillette, Lishan Aklog, Brian J. deGuzman, Richard Yazbeck, Stephen J. O'Neill, Amos G. Cruz, Julian Fricks
  • Patent number: 11986509
    Abstract: The invention provides formulations for oral delivery of a therapeutic agent wherein the formulation comprises a kappa opioid receptor agonist, an oligosaccharide stabilizing agent and an optional absorption enhancer. The kappa opioid receptor agonist may be coated with, embedded in or mixed with an oligosaccharide, such as trehalose. Also provided are capsules containing the oral formulations of the kappa opioid receptor agonists, the oligosaccharide and the absorption enhancer of the invention. The invention further provides methods of manufacture of the formulations and methods of their use for the prophylaxis, inhibition and treatment of variety of kappa opioid receptor-associated diseases and conditions such as pain, pruritus and inflammation. The methods of use include administering to the mammal the formulation of the kappa opioid receptor agonist, oligosaccharide and optional absorption enhancers.
    Type: Grant
    Filed: March 18, 2021
    Date of Patent: May 21, 2024
    Assignee: Cara Therapeutics, Inc.
    Inventors: Bryan R. Wilson, Stephen J. O'Connor
  • Publication number: 20230381265
    Abstract: The invention provides formulations for oral delivery of a therapeutic wherein the formulation comprises a kappa opioid receptor agonist, an oligosaccharide stabilizing agent and an optional absorption enhancer. The kappa opioid receptor agonist may be coated with, embedded in or mixed with an oligosaccharide, such as trehalose. Also provided are capsules containing the oral formulations of the kappa opioid receptor agonists, the oligosaccharide and the absorption enhancer of the invention. The invention further provides methods of manufacture of the formulations and methods of their use for the prophylaxis, inhibition and treatment of variety of kappa opioid receptor-associated diseases and conditions such as pain, pruritus and inflammation. The methods of use include administering to the mammal the formulation of the kappa opioid receptor agonist, oligosaccharide and optional absorption enhancers.
    Type: Application
    Filed: May 30, 2023
    Publication date: November 30, 2023
    Applicant: Cara Therapeutics, Inc.
    Inventors: Bryan R. WILSON, Stephen J. O'CONNOR
  • Publication number: 20230338546
    Abstract: The invention provides formulations for oral delivery of a therapeutic agent wherein the formulation comprises a kappa opioid receptor agonist and an absorption enhancer, the absorption enhancer includes a medium chain fatty acid or a salt of a medium chain fatty acid; and a medium chain fatty acid glyceride. The kappa opioid receptor agonist may be embedded in an oligosaccharide, such as trehalose. Also provided are capsules containing the oral formulations of the kappa opioid receptor agonists and the absorption enhancer of the invention and methods use of these formulations for the prophylaxis and treatment of variety of kappa opioid receptor-associated diseases and conditions such as pain, pruritus and inflammation; the method comprising administering to the mammal the formulation comprising the kappa opioid receptor agonist and an absorption enhancer.
    Type: Application
    Filed: June 20, 2023
    Publication date: October 26, 2023
    Inventors: Bryan R. WILSON, Stephen J. O’CONNOR
  • Patent number: 11684674
    Abstract: The invention provides formulations for oral delivery of a therapeutic agent wherein the formulation comprises a kappa opioid receptor agonist and an absorption enhancer, the absorption enhancer includes a medium chain fatty acid or a salt of a medium chain fatty acid; and a medium chain fatty acid glyceride. The kappa opioid receptor agonist may be embedded in an oligosaccharide, such as trehalose. Also provided are capsules containing the oral formulations of the kappa opioid receptor agonists and the absorption enhancer of the invention and methods use of these formulations for the prophylaxis and treatment of variety of kappa opioid receptor-associated diseases and conditions such as pain, pruritus and inflammation; the method comprising administering to the mammal the formulation comprising the kappa opioid receptor agonist and an absorption enhancer.
    Type: Grant
    Filed: April 28, 2021
    Date of Patent: June 27, 2023
    Assignee: Cara Therapeutics, Inc.
    Inventors: Bryan R. Wilson, Stephen J. O'Connor
  • Patent number: 11315551
    Abstract: This disclosure relates to systems and methods for discovering intents from multimedia conversations. In an implementation, the system may obtain an optimal parameter configuration based on a topic relevance quantifier. The system may extract topics from the audio calls based on the optimal parameter configuration. The system may determine respective context metrics for each of the topics. The system may select a relevant topic with respect to the intent discovery from the extracted topic based on the respective context metrics. The system may obtain documents associated with the relevant topic from the corpus of documents. The system may display information of the documents associated with the relevant topic via a user interface. The system may receive a feedback data with respect to the relevant topic. The system may determine intent information associated with the relevant topic based on the feedback data.
    Type: Grant
    Filed: January 14, 2020
    Date of Patent: April 26, 2022
    Assignee: ACCENT GLOBAL SOLUTIONS LIMITED
    Inventors: Antonio Penta, Osama M. Mohamed, Anandita Pal, Hilary Allen, Hakan Ozkok, Stephen J. O'Kennedy, Onur Can Sert, Andreea-Roxana Miu
  • Publication number: 20210346505
    Abstract: The invention provides formulations for oral delivery of a therapeutic agent wherein the formulation comprises a kappa opioid receptor agonist and an absorption enhancer, the absorption enhancer includes a medium chain fatty acid or a salt of a medium chain fatty acid; and a medium chain fatty acid glyceride. The kappa opioid receptor agonist may be embedded in an oligosaccharide, such as trehalose. Also provided are capsules containing the oral formulations of the kappa opioid receptor agonists and the absorption enhancer of the invention and methods use of these formulations for the prophylaxis and treatment of variety of kappa opioid receptor-associated diseases and conditions such as pain, pruritus and inflammation; the method comprising administering to the mammal the formulation comprising the kappa opioid receptor agonist and an absorption enhancer.
    Type: Application
    Filed: April 28, 2021
    Publication date: November 11, 2021
    Inventors: Bryan R. WILSON, Stephen J. O'CONNOR
  • Publication number: 20210290723
    Abstract: The invention provides formulations for oral delivery of a therapeutic agent wherein the formulation comprises a kappa opioid receptor agonist, an oligosaccharide stabilizing agent and an optional absorption enhancer. The kappa opioid receptor agonist may be coated with, embedded in or mixed with an oligosaccharide, such as trehalose. Also provided are capsules containing the oral formulations of the kappa opioid receptor agonists, the oligosaccharide and the absorption enhancer of the invention. The invention further provides methods of manufacture of the formulations and methods of their use for the prophylaxis, inhibition and treatment of variety of kappa opioid receptor-associated diseases and conditions such as pain, pruritus and inflammation. The methods of use include administering to the mammal the formulation of the kappa opioid receptor agonist, oligosaccharide and optional absorption enhancers.
    Type: Application
    Filed: March 18, 2021
    Publication date: September 23, 2021
    Applicant: CARA THERAPEUTICS, INC.
    Inventors: Bryan R. WILSON, Stephen J. O'CONNOR
  • Patent number: 11033629
    Abstract: The invention provides formulations for oral delivery of a therapeutic agent wherein the formulation comprises a kappa opioid receptor agonist and an absorption enhancer, the absorption enhancer includes a medium chain fatty acid or a salt of a medium chain fatty acid; and a medium chain fatty acid glyceride. The kappa opioid receptor agonist may be embedded in an oligosaccharide, such as trehalose. Also provided are capsules containing the oral formulations of the kappa opioid receptor agonists and the absorption enhancer of the invention and methods use of these formulations for the prophylaxis and treatment of variety of kappa opioid receptor-associated diseases and conditions such as pain, pruritus and inflammation; the method comprising administering to the mammal the formulation comprising the kappa opioid receptor agonist and an absorption enhancer.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: June 15, 2021
    Assignee: Cara Therapeutics, Inc.
    Inventors: Bryan R. Wilson, Stephen J. O'Connor
  • Publication number: 20210142791
    Abstract: This disclosure relates to systems and methods for discovering intents from multimedia conversations. In an implementation, the system may obtain an optimal parameter configuration based on a topic relevance quantifier. The system may extract topics from the audio calls based on the optimal parameter configuration. The system may determine respective context metrics for each of the topics. The system may select a relevant topic with respect to the intent discovery from the extracted topic based on the respective context metrics. The system may obtain documents associated with the relevant topic from the corpus of documents. The system may display information of the documents associated with the relevant topic via a user interface. The system may receive a feedback data with respect to the relevant topic. The system may determine intent information associated with the relevant topic based on the feedback data.
    Type: Application
    Filed: January 14, 2020
    Publication date: May 13, 2021
    Inventors: Antonio Penta, Osama M. Mohamed, Anandita Pal, Hilary Allen, Hakan Ozkok, Stephen J. O'Kennedy, Onur Can Sert, Andreea-Roxana Miu
  • Publication number: 20200085961
    Abstract: The invention provides formulations for oral delivery of a therapeutic agent wherein the formulation comprises a kappa opioid receptor agonist and an absorption enhancer, the absorption enhancer includes a medium chain fatty acid or a salt of a medium chain fatty acid; and a medium chain fatty acid glyceride. The kappa opioid receptor agonist may be embedded in an oligosaccharide, such as trehalose. Also provided are capsules containing the oral formulations of the kappa opioid receptor agonists and the absorption enhancer of the invention and methods use of these formulations for the prophylaxis and treatment of variety of kappa opioid receptor-associated diseases and conditions such as pain, pruritus and inflammation; the method comprising administering to the mammal the formulation comprising the kappa opioid receptor agonist and an absorption enhancer.
    Type: Application
    Filed: September 13, 2019
    Publication date: March 19, 2020
    Inventors: Bryan R. WILSON, Stephen J. O'CONNOR
  • Patent number: 8835422
    Abstract: The present invention provides substituted imidazoheterocycles having the general structure of formula I: wherein Y is chosen from —O—, —OCRgRh—, —CRgRhO—, —CRgRh—, —(CRgRh)2—, —NRi—, —CRgRhNRi— and —NRiCRgRh—. Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.
    Type: Grant
    Filed: December 1, 2009
    Date of Patent: September 16, 2014
    Assignee: Cara Therapeutics, Inc.
    Inventors: Stephen J. O'Connor, Jason S. Newcom, Janet L. Ralbovsky, Gary R. Gustafson, R. Paul Beckett, Robert Zhiyong Luo
  • Patent number: 8549036
    Abstract: This document discusses, among other things, an information technology (IT) enterprise manager system. In one example, the system includes data groups organized into IT Services, IT Resources, and IT Consumers data groups. The IT Resources data group may include one or more of an IT Applications data group, an IT Assets data group, an IT Staff Data group, and an IT Vendors data group. The IT Consumers data group may include one or both of a Business Processes data group and an IT Clients data group. Information in one data group may use a link to other information in another data group. In one example, the system provides tools and methods for managing a portfolio IT projects through various phases of their lifecycles, such as during project definition, establishing a business case for the project, project design and implementation, and/or project wrap-up.
    Type: Grant
    Filed: December 22, 2003
    Date of Patent: October 1, 2013
    Assignee: Bladelogic, Inc.
    Inventors: Stephen J. O'Connor, Thomas M. Niermann
  • Patent number: 8381635
    Abstract: A brewing device comprising a brewing system; a handle assembly coupled to the brewing system and containing a source of compressed fluid; and a valve system, coupled to the handle, to selectively place the source of compressed fluid in fluid communication with the brewing system.
    Type: Grant
    Filed: December 29, 2009
    Date of Patent: February 26, 2013
    Assignee: Espressi, Inc.
    Inventors: Stephen J. O'Brien, Jacques Gagne, Stephen Hooper, Benjamin Pei-Ming Chia, Yi-Chun Liao, Ray Gradwohl, Kenneth Robertson
  • Patent number: 8266096
    Abstract: Various examples include a system and methods in support of vendor relationship management, analysis, planning and evaluation including dealing with collections of vendors called vendor portfolios. In various examples the system includes a database, vendor portfolio definer, a vendor portfolio populator, and a vendor portfolio analyzer. The database houses vendor data. In various examples the vendor portfolio definer allows vendor portfolios to be created, meta data, including complex documents, to be associated with vendor portfolios, and user access permissions to be assigned to vendor portfolios. In various examples the vendor portfolio populator facilitates user selection of the vendors that will make up the collection of vendors in the vendor portfolio. The vendor portfolio analyzer analyzes a business metric using vendor portfolios. In various examples the vendor portfolio analyzer allows user to perform what-if analysis on vendor portfolios.
    Type: Grant
    Filed: October 23, 2009
    Date of Patent: September 11, 2012
    Assignee: BMC Software, Inc.
    Inventors: Jorge A. Navarrete, Stephen J. O'Connor, Peter P. Dai, Johri Dhanotra, Hubert Yau Kin Siu, Charudutt Nagori, Ashish Kalani
  • Publication number: 20120015930
    Abstract: The present invention provides substituted imidazoheterocycles having the general structure of formula I: wherein Y is chosen from —O—, —OCRgRh—, —CRgRhO—, —CRgRh—, —(CRgRh)2—, —NRi—, —CRgRhNRi— and —NRiCRgRh—. Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.
    Type: Application
    Filed: December 1, 2009
    Publication date: January 19, 2012
    Applicant: CARA THERAPEUTICS, INC.
    Inventors: Stephen J. O'Connor, Jason S. Newcom, Janet L. Ralbovsky, Gary R. Gustafson, R. Paul Beckett, Robert Zhiyong Luo
  • Patent number: 8017605
    Abstract: Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of asthma, COPD, ARDS, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.
    Type: Grant
    Filed: June 10, 2009
    Date of Patent: September 13, 2011
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Soumya P. Sahoo, Meng-Hsin Chen, Kevin D. Dykstra, Hiroo Koyama, Peter T. Meinke, Stephen J. O'Keefe, Ginger Xu-qiang Yang
  • Patent number: 8013166
    Abstract: This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: September 6, 2011
    Assignee: Bayer Healthcare LLC
    Inventors: Roger A. Smith, Ann-Marie Campbell, Philip Coish, Miao Dai, Susan Jenkins, Derek Lowe, Stephen J. O'Connor, Ning Su, Gan Wang, Mingbao Zhang, Lei Zhu
  • Patent number: 7968576
    Abstract: This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
    Type: Grant
    Filed: September 8, 2008
    Date of Patent: June 28, 2011
    Inventors: Roger A. Smith, Ann-Marie Campbell, Philip Coish, Miao Dai, Susan Jenkins, Derek Lowe, Stephen J. O'Connor, Ning Su, Gan Wang, Mingbao Zhang, Lei Zhu