Patents by Inventor Stephen J. Shiner
Stephen J. Shiner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12181452Abstract: A chromatographic device including a coated metallic frit is disclosed. The coating is provided over the fluid exposed surfaces of the frit, thereby covering metallic surfaces to prevent interaction with an analyte in the flowstream. This technology relates to the use of a vapor deposition coated frit together with an uncoated frit in a liquid flow path for improved chromatography. More specifically, this technology relates to liquid chromatographic devices for separating analytes in a sample having a single coated frit within an uncoated metallic fluidic flow path (i.e., the column tube or channel is formed of stainless steel, titanium (pure or alloyed), or some mixture of stainless steel and titanium) and does not include the coating applied to the frit.Type: GrantFiled: March 17, 2021Date of Patent: December 31, 2024Assignee: Waters Technologies CorporationInventors: Stephen J. Shiner, Cheryl Boissel, Matthew A. Lauber, Kevin Wyndham, Michael O. Fogwill
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Patent number: 12180581Abstract: A chromatographic device including a coated metallic frit is disclosed. The coating is provided over the fluid exposed surfaces of the frit, thereby covering metallic surfaces to prevent interaction with an analyte in the flowstream. This technology relates to the use of vapor deposition coated frit(s) in a liquid flow path for improved chromatography. More specifically, this technology relates to liquid chromatographic devices for separating analytes in a sample having coated frit(s) within an uncoated metallic fluidic flow path (i.e., the column tube or channel is formed of stainless steel, titanium (pure or alloyed), or some mixture of stainless steel and titanium) and does not include the coating applied to the frit.Type: GrantFiled: February 3, 2021Date of Patent: December 31, 2024Assignee: Waters Technologies CorporationInventors: Stephen J. Shiner, Cheryl Boissel, Matthew A. Lauber, Kevin Wyndham
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Patent number: 12121829Abstract: The present disclosure relates to a filter. The filter includes a porous element, a compression element and a housing. At least a portion of the porous element is coated with an alkylsilyl coating. The compression element is configured to receive the porous element thereby forming an assembly. The housing has an opening formed therein. The opening is configured to receive the assembly. The assembly is retained within the opening when the assembly is received therein.Type: GrantFiled: February 25, 2020Date of Patent: October 22, 2024Assignee: Waters Technologies CorporationInventors: Mathew H. DeLano, Matthew A. Lauber, Michael Donegan, Robert A. Jencks, Stephen J. Shiner
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Publication number: 20230393103Abstract: A device for separating analytes is disclosed. The device has a sample injector, sample injection needle, sample reservoir container in communication with the sample injector, chromatography column downstream of the sample injector, and fluid conduits connecting the sample injector and the column. The interior surfaces of the fluid conduits, sample injector, sample reservoir container, and column form a flow path having wetted surfaces. A portion of the wetted surfaces of the flow path are coated with an alkylsilyl coating that is inert to at least one of the analytes. The alkylsilyl coating has the Formula I: R1, R2, R3, R4, R5, and R6 are each independently selected from (C1-C6)alkoxy, —NH(C1-C6)alkyl, —N((C1-C6)alkyl)2, OH, ORA, and halo. RA represents a point of attachment to the interior surfaces of the fluidic system. At least one of R1, R2, R3, R4, R5, and R6 is ORA. X is (C1-C20)alkyl, —O[(CH2)2O]1-20, -(C1-C10)[NH(CO)NH(C1-C10)]1-20-, or -(C1-C10)[alkylphenyl(C1-C10)alkyl]1-20-.Type: ApplicationFiled: June 7, 2023Publication date: December 7, 2023Applicant: Waters Technologies CorporationInventors: Matthew A. Lauber, Mathew H. DeLano, Scott A. McCall, Jonathan Belanger, Theodore A. Dourdeville, Kerri Smith, Paul Rainville, Dimple Shah, Stephen J. Shiner, Catalin Doneanu, Michael Donegan
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Patent number: 11709155Abstract: A device for separating analytes is disclosed. The device has a sample injector, sample injection needle, sample reservoir container in communication with the sample injector, chromatography column downstream of the sample injector, and fluid conduits connecting the sample injector and the column. The interior surfaces of the fluid conduits, sample injector, sample reservoir container, and column form a flow path having wetted surfaces. A portion of the wetted surfaces of the flow path are coated with an alkylsilyl coating that is inert to at least one of the analytes. The alkylsilyl coating has the Formula I: R1, R2, R3, R4, R5, and R6 are each independently selected from (C1-C6)alkoxy, —NH(C1-C6)alkyl, —N((C1-C6)alkyl)2, OH, ORA, and halo. RA represents a point of attachment to the interior surfaces of the fluidic system. At least one of R1, R2, R3, R4, R5, and R6 is ORA. X is (C1-C20)alkyl, —O[(CH2)2O]1-20—, —(C1-C10)[NH(CO)NH(C1-C10)]1-20—, or —(C1-C10)[alkylphenyl(C1-C10)alkyl]1-20-.Type: GrantFiled: September 17, 2018Date of Patent: July 25, 2023Assignee: Waters Technologies CorporationInventors: Matthew A. Lauber, Mathew H. DeLano, Scott A. McCall, Jonathan L. Belanger, Theodore A. Dourdeville, Kerri M. Smith, Paul D. Rainville, Dimple D. Shah, Stephen J. Shiner, Catalin Doneanu, Michael Donegan
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Publication number: 20230173406Abstract: The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are superficially porous chromatographic particulate materials comprising sized less than 2 microns.Type: ApplicationFiled: January 13, 2023Publication date: June 8, 2023Applicant: Waters Technologies CorporationInventors: Kevin D. Wyndham, Jacob N. Fairchild, Pamela C. Iraneta, Stephen J. Shiner, Darryl W. Brousmiche, Daniel P. Walsh
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Patent number: 11577179Abstract: The present invention provides methods for performing supercritical fluid chromatography comprising loading a sample to be separated by supercritical fluid chromatography onto a stationary phase comprising a spherical, monodisperse, core-shell particulate material comprising a nonporous core and one or more layers of a porous shell material surrounding the core, wherein the particles are sized less than 2 microns; and performing supercritical fluid chromatography to separate the sample.Type: GrantFiled: June 10, 2014Date of Patent: February 14, 2023Assignee: Waters Technologies CorporationInventors: Kevin D. Wyndham, Jacob N. Fairchild, Pamela C. Iraneta, Stephen J. Shiner, Darryl W. Brousmiche, Daniel P. Walsh
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Publication number: 20210223217Abstract: A chromatographic device including a coated metallic frit is disclosed. The coating is provided over the fluid exposed surfaces of the frit, thereby covering metallic surfaces to prevent interaction with an analyte in the flowstream. This technology relates to the use of a vapor deposition coated frit together with an uncoated frit in a liquid flow path for improved chromatography. More specifically, this technology relates to liquid chromatographic devices for separating analytes in a sample having a single coated frit within an uncoated metallic fluidic flow path (i.e., the column tube or channel is formed of stainless steel, titanium (pure or alloyed), or some mixture of stainless steel and titanium) and does not include the coating applied to the frit.Type: ApplicationFiled: March 17, 2021Publication date: July 22, 2021Applicant: Waters Technologies CorporationInventors: Stephen J. Shiner, Cheryl Boissel, Matthew A. Lauber, Kevin Wyndham, Michael O. Fogwill
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Publication number: 20210164094Abstract: A chromatographic device including a coated metallic frit is disclosed. The coating is provided over the fluid exposed surfaces of the frit, thereby covering metallic surfaces to prevent interaction with an analyte in the flowstream. This technology relates to the use of vapor deposition coated frit(s) in a liquid flow path for improved chromatography. More specifically, this technology relates to liquid chromatographic devices for separating analytes in a sample having coated frit(s) within an uncoated metallic fluidic flow path (i.e., the column tube or channel is formed of stainless steel, titanium (pure or alloyed), or some mixture of stainless steel and titanium) and does not include the coating applied to the frit.Type: ApplicationFiled: February 3, 2021Publication date: June 3, 2021Applicant: Waters Technologies CorporationInventors: Stephen J. Shiner, Cheryl Boissel, Matthew A. Lauber, Kevin Wyndham
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Publication number: 20200269157Abstract: The present disclosure relates to a filter. The filter includes a porous element, a compression element and a housing. At least a portion of the porous element is coated with an alkylsilyl coating. The compression element is configured to receive the porous element thereby forming an assembly. The housing has an opening formed therein. The opening is configured to receive the assembly. The assembly is retained within the opening when the assembly is received therein.Type: ApplicationFiled: February 25, 2020Publication date: August 27, 2020Applicant: Waters Technologies CorporationInventors: Mathew H. DeLano, Matthew A. Lauber, Michael Donegan, Robert A. Jencks, Stephen J. Shiner
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Publication number: 20190086371Abstract: A device for separating analytes is disclosed. The device has a sample injector, sample injection needle, sample reservoir container in communication with the sample injector, chromatography column downstream of the sample injector, and fluid conduits connecting the sample injector and the column. The interior surfaces of the fluid conduits, sample injector, sample reservoir container, and column form a flow path having wetted surfaces. A portion of the wetted surfaces of the flow path are coated with an alkylsilyl coating that is inert to at least one of the analytes. The alkylsilyl coating has the Formula I: R1, R2, R3, R4, R5, and R6 are each independently selected from (C1-C6)alkoxy, —NH(C1-C6)alkyl, —N((C1-C6)alkyl)2, OH, ORA, and halo. RA represents a point of attachment to the interior surfaces of the fluidic system. At least one of R1, R2, R3, R4, R5, and R6 is ORA. X is (C1-C20)alkyl, —O[(CH2)2O]1-20—, —(C1-C10)[NH(CO)NH(C1-C10)]1-20-, or —(C1-C10)[alkylphenyl(C1-C10)alkyl]1-20-.Type: ApplicationFiled: September 17, 2018Publication date: March 21, 2019Applicant: Waters Technologies CorporationInventors: Matthew A. Lauber, Mathew H. DeLano, Scott A. McCall, Jonathan L. Belanger, Theodore A. Dourdeville, Kerri M. Smith, Paul D. Rainville, Dimple D. Shah, Stephen J. Shiner, Catalin Doneanu, Michael Donegan
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Patent number: 9724621Abstract: Embodiment of the present invention feature a device having a body, a separation media and a frit element. The exterior surface of the body has a first attachment means positioned radially about at least one of the media chamber and the frit section to form a compact assembly.Type: GrantFiled: May 24, 2013Date of Patent: August 8, 2017Assignee: Waters Technologies CorporationInventors: Jonathan Belanger, Micah Inglis Watt, Stephen J. Shiner
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Publication number: 20170173497Abstract: Embodiment of the present invention feature a device having a body, a separation media and a frit element. The exterior surface of the body has a first attachment means positioned radially about at least one of the media chamber and the frit section to form a compact assembly.Type: ApplicationFiled: May 24, 2013Publication date: June 22, 2017Applicant: Waters Technologies CorporationInventors: Jonathan Belanger, Micah Inglis Watt, Stephen J. Shiner
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Publication number: 20160184736Abstract: The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are superficially porous chromatographic particulate materials comprising sized less than 2 microns.Type: ApplicationFiled: June 10, 2014Publication date: June 30, 2016Applicant: Waters Technologies CorporationInventors: Kevin D. Wyndham, Jacob N. Fairchild, Pamela C. Iraneta, Stephen J. Shiner, Darryl W. Brousmiche, Daniel P. Walsh
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Publication number: 20130256231Abstract: Embodiment of the present invention feature a device having a body, a separation media and a frit element. The exterior surface of the body has a first attachment means positioned radially about at least one of the media chamber and the frit section to form a compact assembly.Type: ApplicationFiled: May 24, 2013Publication date: October 3, 2013Applicant: Waters Technologies CorporationInventors: Jonathan Belanger, Micah Inglis Watt, Stephen J. Shiner
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Patent number: 8449769Abstract: Embodiment of the present invention feature a device having a body, a separation media and a frit element. The exterior surface of the body has a first attachment means positioned radially about at least one of the media chamber and the frit section to form a compact assembly.Type: GrantFiled: February 19, 2008Date of Patent: May 28, 2013Assignee: Waters Technologies CorporationInventors: Jonathan Belanger, Micah Inglis Watt, Stephen J. Shiner
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Publication number: 20110259827Abstract: Embodiment of the present invention feature a device having a body, a separation media and a frit element. The exterior surface of the body has a first attachment means positioned radially about at least one of the media chamber and the frit section to form a compact assembly.Type: ApplicationFiled: February 19, 2008Publication date: October 27, 2011Applicant: WATERS TECHNOLOGIES CORPORATIONInventors: Jonathan Belanger, Micah Inglis Watt, Stephen J. Shiner