Patents by Inventor Stephen J. Shiner

Stephen J. Shiner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12181452
    Abstract: A chromatographic device including a coated metallic frit is disclosed. The coating is provided over the fluid exposed surfaces of the frit, thereby covering metallic surfaces to prevent interaction with an analyte in the flowstream. This technology relates to the use of a vapor deposition coated frit together with an uncoated frit in a liquid flow path for improved chromatography. More specifically, this technology relates to liquid chromatographic devices for separating analytes in a sample having a single coated frit within an uncoated metallic fluidic flow path (i.e., the column tube or channel is formed of stainless steel, titanium (pure or alloyed), or some mixture of stainless steel and titanium) and does not include the coating applied to the frit.
    Type: Grant
    Filed: March 17, 2021
    Date of Patent: December 31, 2024
    Assignee: Waters Technologies Corporation
    Inventors: Stephen J. Shiner, Cheryl Boissel, Matthew A. Lauber, Kevin Wyndham, Michael O. Fogwill
  • Patent number: 12180581
    Abstract: A chromatographic device including a coated metallic frit is disclosed. The coating is provided over the fluid exposed surfaces of the frit, thereby covering metallic surfaces to prevent interaction with an analyte in the flowstream. This technology relates to the use of vapor deposition coated frit(s) in a liquid flow path for improved chromatography. More specifically, this technology relates to liquid chromatographic devices for separating analytes in a sample having coated frit(s) within an uncoated metallic fluidic flow path (i.e., the column tube or channel is formed of stainless steel, titanium (pure or alloyed), or some mixture of stainless steel and titanium) and does not include the coating applied to the frit.
    Type: Grant
    Filed: February 3, 2021
    Date of Patent: December 31, 2024
    Assignee: Waters Technologies Corporation
    Inventors: Stephen J. Shiner, Cheryl Boissel, Matthew A. Lauber, Kevin Wyndham
  • Patent number: 12121829
    Abstract: The present disclosure relates to a filter. The filter includes a porous element, a compression element and a housing. At least a portion of the porous element is coated with an alkylsilyl coating. The compression element is configured to receive the porous element thereby forming an assembly. The housing has an opening formed therein. The opening is configured to receive the assembly. The assembly is retained within the opening when the assembly is received therein.
    Type: Grant
    Filed: February 25, 2020
    Date of Patent: October 22, 2024
    Assignee: Waters Technologies Corporation
    Inventors: Mathew H. DeLano, Matthew A. Lauber, Michael Donegan, Robert A. Jencks, Stephen J. Shiner
  • Publication number: 20230393103
    Abstract: A device for separating analytes is disclosed. The device has a sample injector, sample injection needle, sample reservoir container in communication with the sample injector, chromatography column downstream of the sample injector, and fluid conduits connecting the sample injector and the column. The interior surfaces of the fluid conduits, sample injector, sample reservoir container, and column form a flow path having wetted surfaces. A portion of the wetted surfaces of the flow path are coated with an alkylsilyl coating that is inert to at least one of the analytes. The alkylsilyl coating has the Formula I: R1, R2, R3, R4, R5, and R6 are each independently selected from (C1-C6)alkoxy, —NH(C1-C6)alkyl, —N((C1-C6)alkyl)2, OH, ORA, and halo. RA represents a point of attachment to the interior surfaces of the fluidic system. At least one of R1, R2, R3, R4, R5, and R6 is ORA. X is (C1-C20)alkyl, —O[(CH2)2O]1-20, -(C1-C10)[NH(CO)NH(C1-C10)]1-20-, or -(C1-C10)[alkylphenyl(C1-C10)alkyl]1-20-.
    Type: Application
    Filed: June 7, 2023
    Publication date: December 7, 2023
    Applicant: Waters Technologies Corporation
    Inventors: Matthew A. Lauber, Mathew H. DeLano, Scott A. McCall, Jonathan Belanger, Theodore A. Dourdeville, Kerri Smith, Paul Rainville, Dimple Shah, Stephen J. Shiner, Catalin Doneanu, Michael Donegan
  • Patent number: 11709155
    Abstract: A device for separating analytes is disclosed. The device has a sample injector, sample injection needle, sample reservoir container in communication with the sample injector, chromatography column downstream of the sample injector, and fluid conduits connecting the sample injector and the column. The interior surfaces of the fluid conduits, sample injector, sample reservoir container, and column form a flow path having wetted surfaces. A portion of the wetted surfaces of the flow path are coated with an alkylsilyl coating that is inert to at least one of the analytes. The alkylsilyl coating has the Formula I: R1, R2, R3, R4, R5, and R6 are each independently selected from (C1-C6)alkoxy, —NH(C1-C6)alkyl, —N((C1-C6)alkyl)2, OH, ORA, and halo. RA represents a point of attachment to the interior surfaces of the fluidic system. At least one of R1, R2, R3, R4, R5, and R6 is ORA. X is (C1-C20)alkyl, —O[(CH2)2O]1-20—, —(C1-C10)[NH(CO)NH(C1-C10)]1-20—, or —(C1-C10)[alkylphenyl(C1-C10)alkyl]1-20-.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: July 25, 2023
    Assignee: Waters Technologies Corporation
    Inventors: Matthew A. Lauber, Mathew H. DeLano, Scott A. McCall, Jonathan L. Belanger, Theodore A. Dourdeville, Kerri M. Smith, Paul D. Rainville, Dimple D. Shah, Stephen J. Shiner, Catalin Doneanu, Michael Donegan
  • Publication number: 20230173406
    Abstract: The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are superficially porous chromatographic particulate materials comprising sized less than 2 microns.
    Type: Application
    Filed: January 13, 2023
    Publication date: June 8, 2023
    Applicant: Waters Technologies Corporation
    Inventors: Kevin D. Wyndham, Jacob N. Fairchild, Pamela C. Iraneta, Stephen J. Shiner, Darryl W. Brousmiche, Daniel P. Walsh
  • Patent number: 11577179
    Abstract: The present invention provides methods for performing supercritical fluid chromatography comprising loading a sample to be separated by supercritical fluid chromatography onto a stationary phase comprising a spherical, monodisperse, core-shell particulate material comprising a nonporous core and one or more layers of a porous shell material surrounding the core, wherein the particles are sized less than 2 microns; and performing supercritical fluid chromatography to separate the sample.
    Type: Grant
    Filed: June 10, 2014
    Date of Patent: February 14, 2023
    Assignee: Waters Technologies Corporation
    Inventors: Kevin D. Wyndham, Jacob N. Fairchild, Pamela C. Iraneta, Stephen J. Shiner, Darryl W. Brousmiche, Daniel P. Walsh
  • Publication number: 20210223217
    Abstract: A chromatographic device including a coated metallic frit is disclosed. The coating is provided over the fluid exposed surfaces of the frit, thereby covering metallic surfaces to prevent interaction with an analyte in the flowstream. This technology relates to the use of a vapor deposition coated frit together with an uncoated frit in a liquid flow path for improved chromatography. More specifically, this technology relates to liquid chromatographic devices for separating analytes in a sample having a single coated frit within an uncoated metallic fluidic flow path (i.e., the column tube or channel is formed of stainless steel, titanium (pure or alloyed), or some mixture of stainless steel and titanium) and does not include the coating applied to the frit.
    Type: Application
    Filed: March 17, 2021
    Publication date: July 22, 2021
    Applicant: Waters Technologies Corporation
    Inventors: Stephen J. Shiner, Cheryl Boissel, Matthew A. Lauber, Kevin Wyndham, Michael O. Fogwill
  • Publication number: 20210164094
    Abstract: A chromatographic device including a coated metallic frit is disclosed. The coating is provided over the fluid exposed surfaces of the frit, thereby covering metallic surfaces to prevent interaction with an analyte in the flowstream. This technology relates to the use of vapor deposition coated frit(s) in a liquid flow path for improved chromatography. More specifically, this technology relates to liquid chromatographic devices for separating analytes in a sample having coated frit(s) within an uncoated metallic fluidic flow path (i.e., the column tube or channel is formed of stainless steel, titanium (pure or alloyed), or some mixture of stainless steel and titanium) and does not include the coating applied to the frit.
    Type: Application
    Filed: February 3, 2021
    Publication date: June 3, 2021
    Applicant: Waters Technologies Corporation
    Inventors: Stephen J. Shiner, Cheryl Boissel, Matthew A. Lauber, Kevin Wyndham
  • Publication number: 20200269157
    Abstract: The present disclosure relates to a filter. The filter includes a porous element, a compression element and a housing. At least a portion of the porous element is coated with an alkylsilyl coating. The compression element is configured to receive the porous element thereby forming an assembly. The housing has an opening formed therein. The opening is configured to receive the assembly. The assembly is retained within the opening when the assembly is received therein.
    Type: Application
    Filed: February 25, 2020
    Publication date: August 27, 2020
    Applicant: Waters Technologies Corporation
    Inventors: Mathew H. DeLano, Matthew A. Lauber, Michael Donegan, Robert A. Jencks, Stephen J. Shiner
  • Publication number: 20190086371
    Abstract: A device for separating analytes is disclosed. The device has a sample injector, sample injection needle, sample reservoir container in communication with the sample injector, chromatography column downstream of the sample injector, and fluid conduits connecting the sample injector and the column. The interior surfaces of the fluid conduits, sample injector, sample reservoir container, and column form a flow path having wetted surfaces. A portion of the wetted surfaces of the flow path are coated with an alkylsilyl coating that is inert to at least one of the analytes. The alkylsilyl coating has the Formula I: R1, R2, R3, R4, R5, and R6 are each independently selected from (C1-C6)alkoxy, —NH(C1-C6)alkyl, —N((C1-C6)alkyl)2, OH, ORA, and halo. RA represents a point of attachment to the interior surfaces of the fluidic system. At least one of R1, R2, R3, R4, R5, and R6 is ORA. X is (C1-C20)alkyl, —O[(CH2)2O]1-20—, —(C1-C10)[NH(CO)NH(C1-C10)]1-20-, or —(C1-C10)[alkylphenyl(C1-C10)alkyl]1-20-.
    Type: Application
    Filed: September 17, 2018
    Publication date: March 21, 2019
    Applicant: Waters Technologies Corporation
    Inventors: Matthew A. Lauber, Mathew H. DeLano, Scott A. McCall, Jonathan L. Belanger, Theodore A. Dourdeville, Kerri M. Smith, Paul D. Rainville, Dimple D. Shah, Stephen J. Shiner, Catalin Doneanu, Michael Donegan
  • Patent number: 9724621
    Abstract: Embodiment of the present invention feature a device having a body, a separation media and a frit element. The exterior surface of the body has a first attachment means positioned radially about at least one of the media chamber and the frit section to form a compact assembly.
    Type: Grant
    Filed: May 24, 2013
    Date of Patent: August 8, 2017
    Assignee: Waters Technologies Corporation
    Inventors: Jonathan Belanger, Micah Inglis Watt, Stephen J. Shiner
  • Publication number: 20170173497
    Abstract: Embodiment of the present invention feature a device having a body, a separation media and a frit element. The exterior surface of the body has a first attachment means positioned radially about at least one of the media chamber and the frit section to form a compact assembly.
    Type: Application
    Filed: May 24, 2013
    Publication date: June 22, 2017
    Applicant: Waters Technologies Corporation
    Inventors: Jonathan Belanger, Micah Inglis Watt, Stephen J. Shiner
  • Publication number: 20160184736
    Abstract: The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are superficially porous chromatographic particulate materials comprising sized less than 2 microns.
    Type: Application
    Filed: June 10, 2014
    Publication date: June 30, 2016
    Applicant: Waters Technologies Corporation
    Inventors: Kevin D. Wyndham, Jacob N. Fairchild, Pamela C. Iraneta, Stephen J. Shiner, Darryl W. Brousmiche, Daniel P. Walsh
  • Publication number: 20130256231
    Abstract: Embodiment of the present invention feature a device having a body, a separation media and a frit element. The exterior surface of the body has a first attachment means positioned radially about at least one of the media chamber and the frit section to form a compact assembly.
    Type: Application
    Filed: May 24, 2013
    Publication date: October 3, 2013
    Applicant: Waters Technologies Corporation
    Inventors: Jonathan Belanger, Micah Inglis Watt, Stephen J. Shiner
  • Patent number: 8449769
    Abstract: Embodiment of the present invention feature a device having a body, a separation media and a frit element. The exterior surface of the body has a first attachment means positioned radially about at least one of the media chamber and the frit section to form a compact assembly.
    Type: Grant
    Filed: February 19, 2008
    Date of Patent: May 28, 2013
    Assignee: Waters Technologies Corporation
    Inventors: Jonathan Belanger, Micah Inglis Watt, Stephen J. Shiner
  • Publication number: 20110259827
    Abstract: Embodiment of the present invention feature a device having a body, a separation media and a frit element. The exterior surface of the body has a first attachment means positioned radially about at least one of the media chamber and the frit section to form a compact assembly.
    Type: Application
    Filed: February 19, 2008
    Publication date: October 27, 2011
    Applicant: WATERS TECHNOLOGIES CORPORATION
    Inventors: Jonathan Belanger, Micah Inglis Watt, Stephen J. Shiner