Patents by Inventor Stephen J. Smerdon

Stephen J. Smerdon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR CANCER TREATMENT RELATING TO BRCA1 BRCT DOMAIN RECOGNITION OF PHOSPHORYLATED BACH1
    Publication number: 20120295802
    Abstract: The present invention relates to compounds (e.g., peptidomimetics and non-peptides) that treat, prevent, or stabilize cellular proliferative disorders and methods of treating, preventing, or stabilizing such disorders. The invention also provides three-dimensional structures of a human BRCT domain-BACH1 phosphopeptide complex.
    Type: Application
    Filed: April 19, 2012
    Publication date: November 22, 2012
    Inventors: Michael B. Yaffe, Julie A. Clapperton, Isaac A. Manke, Drew M. Lowery, Stephen J. Smerdon, Lesley F. Haire
  • PRODUCTS AND PROCESSES FOR MODULATING PEPTIDE-PEPTIDE BINDING DOMAIN INTERACTIONS
    Publication number: 20110104713
    Abstract: The present invention relates to therapeutic compounds and methods of use of these therapeutic compounds for treating cellular proliferative disorders. The invention also provides three-dimensional structures of a Polo-like kinase and methods for designing or selecting small molecule inhibitors using these structures, and the therapeutic use of such compounds. The invention also includes a method for identifying novel phosphopeptide-binding domains.
    Type: Application
    Filed: September 29, 2010
    Publication date: May 5, 2011
    Inventors: Michael B. YAFFE, Andrew E. H. Elia, Peter Rellos, Lewis C. Cantley, Stephen J. Smerdon, Isaac Manke
  • Products and processes for modulating peptide-peptide binding domain interactions
    Publication number: 20100030543
    Abstract: The present invention relates to therapeutic compounds and methods of use of these therapeutic compounds for treating cellular proliferative disorders. The invention also provides three-dimensional structures of a Polo-like kinase and methods for designing or selecting small molecule inhibitors using these structures, and the therapeutic use of such compounds. The invention also includes a method for identifying novel phosphopeptide-binding domains.
    Type: Application
    Filed: August 27, 2008
    Publication date: February 4, 2010
    Inventors: Michael B. Yaffe, Andrew E. H. Elia, Peter Rellos, Lewis C. Cantley, Stephen J. Smerdon, Isaac Manke
  • Methods and compositions for cancer treatment relating to BRCA1 BRCT domain recognition of phosphorylated BACH1
    Publication number: 20090143997
    Abstract: The present invention relates to compounds (e.g., peptidomimetics and non-peptides) that treat, prevent, or stabilize cellular proliferative disorders and methods of treating, preventing, or stabilizing such disorders. The invention also provides three-dimensional structures of a human BRCT domain-BACH1 phosphopeptide complex.
    Type: Application
    Filed: August 26, 2008
    Publication date: June 4, 2009
    Inventors: Michael B. Yaffe, Julie A. Clapperton, Isaac A. Manke, Drew M. Lowery, Stephen J. Smerdon, Lesley F. Haire
  • TPL-2/COT kinase and methods of use
    Publication number: 20030219427
    Abstract: It is shown that TPL-2 is responsible for phosphorylation of p105 and its resultant proteolysis, which leads to p50 Rel translocation to the nucleus. Accordingly, the invention provides TPL-2 as a specific regulator of the activation of NF&kgr;B, and thus as a modulator of inflammatory responses in which p1O5 is involved, and as a target for the development of compounds capable of influencing NF&kgr;B activation.
    Type: Application
    Filed: February 26, 2003
    Publication date: November 27, 2003
    Inventors: Hamish J. Allen, Richard W. Dixon, Joanne S. Kamens, Dineli Wickramasinghe, Yajun Xu, Nancy Bump, Andres Salmeron, Monica P. Belich, Leland H. Johnston, Steven C. Ley, Steven J. Gamblin, Stephen J. Smerdon, Soeren Beinke, Juergen Deka