Abstract: The invention described herein relates to a prodrug that is converted into a dopamine agonist. The dopamine prodrug may be combined with one or more dopamine antagonists, dopamine receptor inhibitors, or vesicular monoamine transport inhibitors. A prodrug is a biologically inactive compound that can be metabolized by the body into its active form. For example, a prodrug placed on the ocular surface can undergo hydrolysis during penetration of the ocular surface, resulting in a biologically active drug. A prodrug allows for use of a lower concentration of the drug and protects against undesirable side effects. A prodrug can also help augment drug uptake into the target tissue.

Abstract: Methods of treating a subject for a microbial eye condition are provided. Aspects of the methods include administering to the subject an activated sodium chlorite composition, where the compositions include sodium chlorite; and a buffer component prepared from sodium phosphate monobasic monohydrate and citric acid. Also provided are methods of inhibiting a virus associated with a tissue, such as an adenovirus or coronavirus. In addition, delivery devices for administering an activated sodium chlorite composition to a tissue are provided.

Abstract: Therapeutic agent delivery devices are provided. Aspects of the devices include an active agent composition and an actuator configured to deliver the active agent composition to a target delivery site. In some instances, aspects of the devices include a syringe comprising a viscous active agent composition, a needle operably coupled to the syringe and an actuator configured to deliver viscous active agent composition from the syringe through the needed to a target delivery site, such as an intravitreal site. In some instances, aspects of the devices include a sleeve comprising a solid formulation of the active agent; a needle operably coupled to the sleeve; and an actuator configured to move the solid formulation from the sleeve and through the needle, e.g., to an intravitreal location.

Abstract: Specific binding members directed to eotaxin-1, in particular human antibodies and antibody fragments against human eotaxin-1 and especially those which neutralise eotaxin-1 activity. The antibodies VH and/or VL domain of the scFv fragment herein termed CAT-212 and of the IgG4 antibody herein termed CAT 213. One or more complementary determining regions (CDRs) of the CAT-212/-213 VH and/or VL domains, especially VH CRD3 in other antibody framework regions. Compositions containing specific binding members, and their use in methods of inhibiting or neutralising eotaxin, including methods of treatment of the human or animal body by therapy.

Abstract: Therapeutic agent delivery devices are provided. Aspects of the devices include a syringe that is not surface sterilized, a tip that includes a sterile tissue contacting surface and a needle operably coupled to the syringe and the tip. Also provided are methods of using the devices.

Abstract: Therapeutic agent delivery devices having integrated pain mitigation are provided. Aspects of the devices include a therapeutic agent delivery system; and an actuator component, where the therapeutic agent delivery system is present in a receiving space of the actuator component. The therapeutic agent delivery system includes dmg container, a needle and a tissue contacting tip. The actuator component includes a therapeutic agent delivery system actuator and a pain mitigation system. Also provided are methods of using the devices, as well as kits that include various components of the systems.

Abstract: A system and method are provided for measuring, at a fluid flow rate gauge, a fluid flow rate returning from a well, for providing, by the fluid flow rate gauge, a fluid flow rate output, for measuring, by a sand flow rate gauge, a sand flow rate of sand entrained in the fluid providing, by the sand flow rate gauge, a sand flow rate output, for receiving, at input circuits of a control system, the fluid flow rate output and the sand flow rate output, for providing, at a display controller of the control system, a display output; receiving, at a display panel, the display output, and for displaying, at the display panel, the fluid flow rate and the sand flow rate, in accordance with at least one embodiment. Embodiments can also include selecting between a first and second plug catcher or a first and second choke.

Abstract: An adaptive computing engine (ACE) IC includes a plurality of heterogeneous computational elements coupled to an interconnection network. The plurality of heterogeneous computational elements include corresponding computational elements having fixed and differing architectures, such as fixed architectures for different functions such as memory, addition, multiplication, complex multiplication, subtraction, configuration, reconfiguration, control, input, output, and field programmability. In response to configuration information, the interconnection network is operative to configure and reconfigure the plurality of heterogeneous computational elements for a plurality of different functional modes, including linear algorithmic operations, non-linear algorithmic operations, finite state machine operations, controller operations, memory operations, and bit-level manipulations.

Abstract: High-resolution three-dimensional imaging of a specimen is facilitated. According to an example embodiment of the present invention, a series of very thin slices from a specimen are serially and robustly arranged on an imaging device such as a microscope slide. The slices are imaged and the images are used to reconstruct a three-dimensional image having high resolution at depths into the specimen. The serial arrangement of the slices facilitates the proper ordering of images for reconstruction. Further, the robust nature of the slice arrangement facilitates treatment of the slices and, in some applications, multiple treatments with corresponding imaging sequences for each treatment. Various embodiments are directed to methods and arrangements for three-dimensional characterization of biological specimen and to data that is accessible and/or executable by a computer for linking different images together in order to characterize such biological specimen in three dimensions.

Abstract: The present invention concerns configuration of a new category of integrated circuitry for adaptive computing. The various embodiments provide an executable information module for an adaptive computing engine (ACE) integrated circuit and may include configuration information, operand data, and may also include routing and power control information. The ACE IC comprises a plurality of heterogeneous computational elements coupled to an interconnection network. The plurality of heterogeneous computational elements include corresponding computational elements having fixed and differing architectures, such as fixed architectures for different functions such as memory, addition, multiplication, complex multiplication, subtraction, configuration, reconfiguration, control, input, output, and field programmability. In response to configuration information, the interconnection network is operative to configure the plurality of heterogeneous computational elements for a plurality of different functional modes.

Abstract: High-resolution three-dimensional imaging of a specimen is facilitated. According to an example embodiment of the present invention, a series of very thin slices from a specimen are serially and robustly arranged on an imaging device such as a microscope slide. The slices are imaged and the images are used to reconstruct a three-dimensional image having high resolution at depths into the specimen. The serial arrangement of the slices facilitates the proper ordering of images for reconstruction. Further, the robust nature of the slice arrangement facilitates treatment of the slices and, in some applications, multiple treatments with corresponding imaging sequences for each treatment. Various embodiments are directed to methods and arrangements for three-dimensional characterization of biological specimen and to data that is accessible and/or executable by a computer for linking different images together in order to characterize such biological specimen in three dimensions.

Abstract: Embodiments of the invention are generally directed to transmission of multiple protocol data elements via an interface utilizing a data tunnel over a control channel. An embodiment of an apparatus includes a transmitter or receiver for the transmission or reception of data; a processing element for handling the data of the apparatus; and a connector for the transfer of the data, the connector to connect to a data channel and to connect to a control channel. The processing element is to provide for transfer of data of a first protocol in the control channel, the transfer of data via the control channel including the use of one or more generic commands of the first protocol for the transfer of data of a second protocol. Data of the second protocol is optimized before the data of the second protocol is sent over the first protocol, and the data transfer in the data channel and data transfer in the control channel are simultaneous at least in part.

Abstract: High-resolution three-dimensional imaging of a specimen is facilitated. According to an example embodiment of the present invention, a series of very thin slices from a specimen are serially and robustly arranged on an imaging device such as a microscope slide. The slices are imaged and the images are used to reconstruct a three-dimensional image having high resolution at depths into the specimen. The serial arrangement of the slices facilitates the proper ordering of images for reconstruction. Further, the robust nature of the slice arrangement facilitates treatment of the slices and, in some applications, multiple treatments with corresponding imaging sequences for each treatment. Various embodiments are directed to methods and arrangements for three-dimensional characterization of biological specimen and to data that is accessible and/or executable by a computer for linking different images together in order to characterize such biological specimen in three dimensions.

Abstract: High cycle fatigue testing is required with regard to a large number of components in order to evaluate their performance and capabilities. Typically such components are mounted such that an excitation mechanism such as through use of air jets can be utilized in order to stimulate vibration. In order to isolate a desired vibration mode generally, an isolation device is utilized. The isolation device presents an edge to a node within the component in order to inhibit vibration modes other than that of interest. Unfortunately, prior isolation elements tend to wear resulting in spurious results. By providing an isolation element within an isolation device, a fatigue test arrangement can be achieved in which both axial movement in the direction of a spring upon which the element is presented as well as lateral movement can be achieved.

Abstract: The present invention concerns configuration of a new category of integrated circuitry for adaptive computing. The various embodiments provide an executable information module for an adaptive computing engine (ACE) integrated circuit and may include configuration information, operand data, and may also include routing and power control information. The ACE IC comprises a plurality of heterogeneous computational elements coupled to an interconnection network. The plurality of heterogeneous computational elements include corresponding computational elements having fixed and differing architectures, such as fixed architectures for different functions such as memory, addition, multiplication, complex multiplication, subtraction, configuration, reconfiguration, control, input, output, and field programmability. In response to configuration information, the interconnection network is operative to configure the plurality of heterogeneous computational elements for a plurality of different functional modes.

Abstract: The present invention concerns configuration of a new category of integrated circuitry for adaptive computing. The various embodiments provide an executable information module for an adaptive computing engine (ACE) integrated circuit and may include configuration information, operand data, and may also include routing and power control information. The ACE IC comprises a plurality of heterogeneous computational elements coupled to an interconnection network. The plurality of heterogeneous computational elements include corresponding computational elements having fixed and differing architectures, such as fixed architectures for different functions such as memory, addition, multiplication, complex multiplication, subtraction, configuration, reconfiguration, control, input, output, and field programmability. In response to configuration information, the interconnection network is operative to configure the plurality of heterogeneous computational elements for a plurality of different functional modes.

Abstract: Vibration test arrangements incorporate an isolation device. In order to allow the isolation device to operate on one side only of a component subject to vibration testing a clamp association is provided between isolation elements. An abutment pressure to retain and present the component is generated between the isolation elements utilizing the clamp association and an appropriate displacement mechanism. The displacement mechanism is controlled by a controller in a control loop incorporating a sensor to determine operational characteristics of the arrangement and appropriate drivers for the displacement mechanism.

Abstract: Embodiments of the invention are generally directed to transmission of multiple protocol data elements via an interface utilizing a data tunnel over a control channel. An embodiment of an apparatus includes a transmitter or receiver for the transmission or reception of data; a processing element for handling the data of the apparatus; and a connector for the transfer of the data, the connector to connect to a data channel and to connect to a control channel. The processing element is to provide for transfer of data of a first protocol in the control channel, the transfer of data via the control channel including the use of one or more generic commands of the first protocol for the transfer of data of a second protocol. Data of the second protocol is optimized before the data of the second protocol is sent over the first protocol, and the data transfer in the data channel and data transfer in the control channel are simultaneous at least in part.

Abstract: Testing of components for fatigue under vibration conditions is important. Typically an isolation device is utilized in order to isolate a mode of vibration of interest. Isolation is through engaging a node line utilizing isolation elements. By presenting the isolation elements in arms a component can be isolated by engaging the component to one side. The isolation elements are suspended upon springs and allowed to move axially in the direction of the springs as well as laterally through mountings in the arms. The isolation elements are less acceptable to wear and test set up time is reduced by the engaging of component to one side only of the component.

Abstract: The present invention concerns configuration of a new category of integrated circuitry for adaptive or reconfigurable computing. The preferred adaptive computing engine (ACE) IC includes a plurality of heterogeneous computational elements coupled to an interconnection network. The plurality of heterogeneous computational elements include corresponding computational elements having fixed and differing architectures, such as fixed architectures for different functions such as memory, addition, multiplication, complex multiplication, subtraction, configuration, reconfiguration, control, input, output, and field programmability.