Abstract: A process for maximizing the transmission of transgenic traits in autopolyploid transgenic plants is provided. According to the process, a plurality of autopolyploid transgenic plant lines, each having a recombinant transgene incorporated into a different region of the plant genome, and each exhibiting a transgenic trait attributable to the transgene, are intercrossed to obtain progeny plants that are trihomogenic and/or tetrahomogenic for the transgenes. These plants are advantageously used in the production of synthetic generations of transgenic plants in which a very high percentage of plants exhibit the transgenic trait. The process affords a significant reduction in resources required to achieve high transmission of transgenic traits in autotetraploid plants and reduces the risks associated with inbreeding, genetic drift, or gene silencing.