Abstract: Described herein are modified oncolytic viruses that can contain modifications in the viral genome and exogenous nucleic acids coding for proteins. The modified oncolytic virus can be utilized as a platform vector for systemic delivery. Further described herein are oncolytic viruses having an exogenous nucleic acid that codes for a protein or a functional variant thereof that enhances degradation of an extracellular matrix (ECM) associated with a tumor, wherein the protein is a membrane associated protein.

Abstract: The disclosure relates to modified oncolytic viruses. The modified oncolytic viruses of the disclosure comprise modification in the viral genome encoding exogenous nucleic acids to enhance the oncolytic immunotherapy by remodeling the tumor microenvironment and with enhanced systemic delivery. The disclosure further relates to compositions comprising the modified oncolytic viruses, kits containing the same, and methods of using the oncolytic viruses.

Abstract: A polyisocyanate mixture which is emulsifiable in water comprising;(i) An isocyanate functional oligomer, which is the reaction product of;(a) a polyisocyanate having tertiary isocyanate groups, and(b) a hydrophilic polyether having a group which will react with tertiary isocyanate groups, and(ii) a polyisocyanate having tertiary isocyanate groups.The polyisocyanate mixtures can be used with suitable filmforming polymers to make aqueous coating compositions.

Abstract: An aqueous coating composition comprising a film-forming material, a metallic pigment, phosphate inhibitor being either an orthophosphoric acid or an organic acid ester of phosphoric acid containing a group of formula (I): ##STR1## a cationic salt of one or more of the following metals: sodium, potassium, magnesium, calcium, strontium, barium, vanadium, cobalt, nickel, copper, zinc or silver; and a water containing diluent.

Abstract: The tendency of metallic pigments, especially of aluminum flake pigments, to react with the aqueous medium of a water-born paint composition with the generation of gaseous material is prevented or reduced by incorporating in the composition an agent containing in the molecule at least one P--OH group, or a salt derivative thereof, which is obtained by reacting a compound containing the grouping --O--PO(OH.sub.2) with one or more epoxide group-containing compounds at least one of which also contains at least one aromatic or alicyclic group.

Abstract: The production is described of a dispersion of polymer microparticles, which may optionally be crosslinked, by dispersion polymerisation in aliphatic hydrocarbon liquid under specified conditions of a monomer mixture which comprises up to 50% of styrene or a substituted derivative thereof and up to 50% by weight of a derivative of maleic acid or fumaric acid which is soluble in the hydrocarbon liquid at the polymerization temperature. The microparticles have a size in the range 100-400 nm and a high refractive index, and are suitable for incorporation in coating compositions which are based on a film-forming polymer, such as a thermosetting acrylic resin or an alkyd resin, containing a significant proportion of aromatic residues, and which are intended to be used either unpigmented or when containing only light-absorbing pigments.