Abstract: The present disclosure relates to certain (2S)—N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: Disclosed herein are antibacterial compounds that accumulate in Gram-negative bacteria, methods of preparing the compounds, and methods of using the compounds to inhibit or kill microbes, and methods of treating microbial infections, such as Gram-negative bacterial infections. Compounds selected for conversion to potential Gram-negative antibacterial compounds were identified based on compounds having low globularity and low flexibility. Amine substituents were then strategically added to the selected compounds to provide compounds having antibacterial activity against Gram-negative bacteria.

Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.

Abstract: A circuit connector for a humidification system, the system comprising a base unit configured to be engaged by a humidification chamber. The circuit connector comprises an inlet to fluidly connect to an outlet of the humidification chamber to receive humidified gases therefrom, an outlet to sealably connect to or integral with a conduit for directing the humidified gases to a user, and an electrical terminal for electrically coupling the circuit connector to an electrical terminal associated with the base unit. The circuit connector may be releasably and lockably connectable to the outlet of the humidification chamber and/or orientation features may control orientation of component parts of the system as they are assembled.

Abstract: The present invention relates generally to diagnostic and therapeutic agents. More particularly, the present invention provides mammalian transcription factors which function in the modulation of expression of genetic sequences. The present invention further provides nucleic acid molecules encoding the transcription factors as well as nucleic acid and/or proteinaceous molecules with which the transcription factors interact. The transcription factors of the present invention or molecules interacting with same may be used inter alia in the generation of a range of diagnostic and therapeutic agents for a range of conditions.

Abstract: The present invention provides mammalian homologs of the Drosophila Grainyhead (GRH) transcription factor, call MGR and means of identifying such proteins and their genes. Nucleic acid and protein sequences are provided for human and mouse MGR transcription factors. In addition mammalian isoforms of MGR including human MGR p49, human p70, mouse p70, mouse MGR p61, and human and mouse homologs of MGR, brother of mgr (BOM) and sister of mgr (SOM), are disclosed. Antibodies to and methods of using these identified MGR, BOM and SOM transcription factors are also provided. The present invention further provides medical assessment systems including drug evaluation systems comprising genetically modified animals.

Abstract: Methods and systems for efficient testing of intermittently operated devices in networks.

Abstract: The present invention provides mammalian homologs of the Drosophila Grainyhead (GRH) transcription factor, call MGR and means of identifying such proteins and their genes. Nucleic acid and protein sequences are provided for human and mouse MGR transcription factors. In addition mammalian isoforms of MGR including human MGR p49, human p70, mouse p70, mouse MGR p61, and human and mouse homologs of MGR, brother of mgr (BOM) and sister of mgr (SOM), are disclosed. Antibodies to and methods of using these identified MGR, BOM and SOM transcription factors are also provided. The present invention further provides medical assessment systems including drug evaluation systems comprising genetically modified animals.

Abstract: A system and method to enable balanced resource utilization during testing of a wireless communications network. The system and method determines the properties, including the status, for resources, and stores the properties for later comparison. Utilization information is calculated from the properties and provided to the user based on criteria from user-specified resource filters. Balanced resource utilization is enabled based on the utilization information.

Abstract: A system and method to provide simulations of tests that execute in a communications network environment. The system and method include a test object and a simulator framework, coupled with an agent manager. The test object can initiate either live or simulated testing, or both. Live test characteristics, that result from the execution of the live test, can be used to create a test characteristics for the same test that is simulated by the simulator framework. The agent manager, coupled directly and/or through storage media to the simulator framework and the test object, can provide the results of live or simulated testing.

Abstract: The system and method of the present invention combine multiple tests (15) into a batch and submit the batch for processing to exercise electronic circuits, for example, a managed network (25) such as a wireless network. The system and method insure that tests (15) are timely run by utilization of a batch submit trigger (42). When a test (15) has completed, the system and method return the results (11) of that particular test (15) to the user, regardless of whether or not the rest of the tests (15) in the batch have completed execution.

Abstract: A method and apparatus are provided for evaluating Service Level Agreements (SLAs) that describe the level of services that are to be provided to customers by Internet Service Providers (ISPs) or Enterprise Service Providers (ESPs). The method and apparatus are utilized to measure the quality of service being provided to customers and to determine whether or not the quality of service is in compliance with an SLA that characterizes the level of service to be provided to customers. Such services include, for example, electronic mail (e-mail), Voice-Over-IP (Voice Over Internet protocol), networking services and web hosting.