Abstract: The present invention relates to monolithic bodies, uses thereof and processes for the preparation thereof. Certain embodiments of the present invention relate to the use of a monolithic body in the preparation of a radioactive substance, for example a radiopharmaceutical, as part of a microfluidic flow system and a process for the preparation of such a monolithic body.

Abstract: Embodiments of the present invention relate to microfluidic devices and systems comprising such devices for use in the determination of sample characteristics. Certain embodiments relate to methods for determining one or more characteristics of a sample comprising a compound for in vivo use. Aptly, certain embodiments of the present invention relate to devices and methods for assessing radiopharmaceuticals and their suitability for administration to a patient in need thereof.

Abstract: Certain embodiments of the present invention relate to a system and a method for producing a radiopharmaceutical, wherein the system is formed from and/or provides a microfluidic flow system. In certain embodiments, the system comprises a radioisotope isolation module, a radiopharmaceutical production module, a purification module and a quality control module.

Abstract: Embodiments of the present invention relate to microfluidic devices and systems comprising such devices for use in the determination of sample characteristics. Certain embodiments relate to methods for determining one or more characteristics of a sample comprising a compound for in vivo use. Aptly, certain embodiments of the present invention relate to devices and methods for assessing radiopharmaceuticals and their suitability for administration to a patient in need thereof.

Abstract: Certain embodiments of the present invention relate to a system and a method for producing a radiopharmaceutical, wherein the system is formed from and/or provides a microfluidic flow system. In certain embodiments, the system comprises a radioisotope isolation module, a radiopharmaceutical production module, a purification module and a quality control module.

Abstract: The present invention relates to a method and an apparatus for separating and recovering a radioisotope from a solution. More particularly, certain embodiments of the invention relate to a method for recovering a radioisotope from a solution by electro-trapping and release using a microfluidic cell (10). The radioisotope may subsequently be used in the preparation of radiopharmaceuticals.

Abstract: The present invention relates to monolithic bodies, uses thereof and processes for the preparation thereof. Certain embodiments of the present invention relate to the use of a monolithic body in the preparation of a radioactive substance, for example a radiopharmaceutical, as part of a microfluidic flow system and a process for the preparation of such a monolithic body.

Abstract: An integrated gel based microfluidic sample processing device, suitable for forensic investigations at the scene of a crime, including a substrate having a plurality of micro-channels to form at least a DNA extraction chamber in fluidic cooperation with an amplification chamber which in turn is in fluidic cooperation with a separation and detection channel. The micro-channels containing a DNA extraction material and gel based reaction reagents necessary for processing the sample. The device further having electrical contacts for coupling to an external power source and capable of inducing electro-kinetic manipulation of the gel based reagents and DNA extracted from the sample throughout the device.

Abstract: A method of amplifying nucleic acid includes providing a microfluidic device having a space therein. The space is filled with a gel medium. Reagents for carrying out a PCR reaction are supported within the matrix of the gel medium within the space. A nucleic acid containing sample is brought into contact with the gel medium. The sample having whole cells or cell lysate without any prior separation of the nucleic acid from other components of the cells. PCR amplification of nucleic acid from the sample is performed in the space using the PCR reagents.

Abstract: An integrated gel based microfluidic sample processing device, suitable for forensic investigations at the scene of a crime, including a substrate having a plurality of micro-channels to form at least a DNA extraction chamber in fluidic cooperation with an amplification chamber which in turn is in fluidic cooperation with a separation and detection channel. The micro-channels containing a DNA extraction material and gel based reaction reagents necessary for processing the sample. The device further having electrical contacts for coupling to an external power source and capable of inducing electro-kinetic manipulation of the gel based reagents and DNA extracted from the sample throughout the device.

Abstract: A carboxylic acid molecule (R COOH) is subjected to an electric field in a micro-reactor. The molecule decarboxyles to form a radical (R•). Two radicals (R•) can dimerise to form the product (R—R). It is believed that the reaction occurs away from the electrodes used to apply the electric field (but may also occur at the electrode surfaces).

Abstract: A micro-reactor is provided with a mixture of channels having larger cross-sectional areas (17?,22?,25?,27?,31?,33?) and channels having smaller cross-sectional areas (40a?,40b?,40c?). The smaller channels (40a?,40b?,40c?) resist liquid movement driven by hydrostatic force but allow liquid movement driven by electro-osmotic force. Accordingly liquid flow is almost entirely driven by electro-osmotic force. The smaller channels (40a?,40b?,40c?) are formed by etched grooves which are closed by a planar surface 13. This allows the cross-sectional areas of the smaller channels to be closely and reproducibly controlled.

Abstract: A micro-reactor (10) is formed from a first glass block (11) having first and second grooves (14,17) formed in an upper surface (13) and a second glass block (12) having a lower surface (26) that closes the first groove (14) and parts of the second groove (17) to form corresponding channels. An aperture (31) extends through the second block (12) to a part of the upper surface (13) of the first block (11). This part (called the inner surface 32) has a number of parts (called the inner surface grooves) of the second groove (17) formed in it. The inner surface grooves can be closed by an end surface of a cylindrical insert (37) to form corresponding channel parts. A first chemical species can be bound to the end surface of the cylindrical insert (37) so that the first chemical species lies within the channel parts corresponding to the inner surface grooves. A second chemical species can now be passed through the channels of the micro-reactor for binding between the first and second chemical species.

Abstract: A carboxylic acid molecule (R COOH) is subjected to an electric field in a micro-reactor (11). The molecule decarboxyles to form a radical (R•). Two radicals (R•) can dimerise to form the product (R-R). It is believed that the reaction occurs away from the electrodes used to apply the electric field (but may also occur at the electrode surfaces).

Abstract: A micro-reactor is provided with a mixture of channels having larger cross-sectional areas (17′,22′,25′,27′,31′,33′) and channels having smaller cross-sectional areas (40a′,40b′,40c′). The smaller channels (40a′,40b′,40c′) resist liquid movement driven by hydrostatic force but allow liquid movement driven by electro-osmotic force. Accordingly liquid flow is almost entirely driven by electro-osmotic force. The smaller channels (40a′,40b′,40c′) are formed by etched grooves which are closed by a planar surface 13. This allows the cross-sectional areas of the smaller channels to be closely and reproducibly controlled.

Abstract: A method of controlling liquid movement in a chemical device comprising a porous structure involved applying an electrical potential to generate an electroosmotic force in the porous structure so as to propel a liquid through the porous structure. Also the porous structure is used to resist or prevent flow of a liquid through the porous structure in response to hydrostatic force.