Abstract: Systems and methods for automated path-based recommendation for risk mitigation are provided. An entity assessment server, responsive to a request for a recommendation for modifying a current risk assessment score of an entity to a target risk assessment score, accesses an input attribute vector for the entity and clusters of entities defined by historical attribute vectors. The entity assessment server assigns the input attribute vector to a particular cluster and determines a requirement on movement from a first point to a second point in a multi-dimensional space based on the statistics computed from the particular cluster. The first point corresponds to the current risk assessment score and the second point corresponds to the target risk assessment score. The entity assessment server computes an attribute-change vector so that a path defined by the attribute-change vector complies with the requirement and generates the recommendation from the attribute-change vector.

Abstract: A method is provided for deterministically translocating through a nanopore a target polymer molecule of a nucleic acid polymer molecule or a protein polymer molecule. In the method, an enzyme clamp is reversibly bound to a plurality of sequential polymer subunits of the target polymer molecule. The target polymer molecule and the enzyme clamp are disposed at the nanopore. In the method, there is applied a pulse of force operative to deterministically advance the enzyme clamp along the target polymer molecule by no more than one polymer subunit. The pulse of force is then repeatedly applied to cause deterministic translocation of a sequential plurality of polymer subunits of the target polymer molecule through the nanopore.

Abstract: In some aspects, a computing system can generate and optimize a machine learning model to estimate an unobservable capacity of a target system or entity. The computing system can access training vectors which include training predictor variables, training performance indicators, and task quantities. A training performance indicator indicating performance outcome corresponding to the predictor variables and a task quantity associated with a task assigned to the target entity that leads to the training performance indicator. The machine learning model can be trained by performing adjustments of parameters of the machine learning model to minimize a loss function defined based on the training vectors. The trained machine learning model can be used to estimate the capacity of the target system or entity for handling tasks and be used in assigning tasks to the target entity according to the determined capacity.

Abstract: A system may identify, using a machine learning model, a series of recurring events associated with an account and may generate, using the machine learning model, a prediction of a future date on which a predicted event, associated with the series of recurring events, is to occur. The system may determine that a condition associated with the account is satisfied and may determine that a current date is within a threshold number of days of the future date based on the prediction of the future date. The system may transmit, to a user device, a notification based on determining that the current date is within the threshold number of days of the future date and that the condition associated with the account is satisfied, wherein the notification includes information for presentation of an input element that enables an action to be performed in connection with the account.

Abstract: A nanopore system provided herein includes first and second fluidic reservoirs in fluidic communication with a nanopore forming a fluidic path between the reservoirs. An enzyme clamp, provided in the first fluidic reservoir, abuts the nanopore and is reversibly bound to a sequential plurality of polymer subunits of a target polymer molecule in ionic solution. The clamp has an outer clamp diameter that is greater than the nanopore diameter. An electrical circuit includes an electrode in each of the reservoirs for applying a voltage bias across the nanopore. A pulse generator is connected in the electrical circuit to apply control pulses across the nanopore to step the clamp along sequential polymer subunits of the target polymer molecule. The system includes no fuel or source of fuel for the clamp. A controller is connected in the electrical circuit for controlling the collection of electrical indications of polymer subunits.

Abstract: A system may identify, using a machine learning model, a series of recurring events associated with an account and may generate, using the machine learning model, a prediction of a future date on which a predicted event, associated with the series of recurring events, is to occur. The system may determine that a condition associated with the account is satisfied and may determine that a current date is within a threshold number of days of the future date based on the prediction of the future date. The system may transmit, to a user device, a notification based on determining that the current date is within the threshold number of days of the future date and that the condition associated with the account is satisfied, wherein the notification includes information for presentation of an input element that enables an action to be performed in connection with the account.

Abstract: Long tunnels of many kilometres are likely to pass through a range of geologies which may cause problems. The present invention seeks to overcome the disadvantages of the prior art by: drilling a first bore 10 along a first predetermined path, the first bore having a length of at least 25 m; drilling a plurality of second bores 20 along respective second predetermined paths, each substantially parallel to the first predetermined path in order to define a substantially prism-shape region therebetween; and excavating material within the substantially prism-shape region to form a tunnel. In this way, data from drilling the first bore 10 and the plurality of second bores 20 can be recorded and used to inform operators as to the types of material through which they will be excavating. Thus, a more complete view of the underlying geology can be achieved before beginning excavations.

Abstract: Long tunnels of many kilometres are likely to pass through a range of geologies which may cause problems. The present invention seeks to overcome the disadvantages of the prior art by: drilling a first bore 10 along a first predetermined path, the first bore having a length of at least 25 m; drilling a plurality of second bores 20 along respective second predetermined paths, each substantially parallel to the first predetermined path in order to define a substantially prism-shape region therebetween; and excavating material within the substantially prism-shape region to form a tunnel. In this way, data from drilling the first bore 10 and the plurality of second bores 20 can be recorded and used to inform operators as to the types of material through which they will be excavating. Thus, a more complete view of the underlying geology can be achieved before beginning excavations.

Abstract: A system may identify, using a machine learning model, a series of recurring events associated with an account and may generate, using the machine learning model, a prediction of a future date on which a predicted event, associated with the series of recurring events, is to occur. The system may determine that a condition associated with the account is satisfied and may determine that a current date is within a threshold number of days of the future date based on the prediction of the future date. The system may transmit, to a user device, a notification based on determining that the current date is within the threshold number of days of the future date and that the condition associated with the account is satisfied, wherein the notification includes information for presentation of an input element that enables an action to be performed in connection with the account.

Abstract: Long tunnels of many kilometres are likely to pass through a range of geologies which may cause problems. The present invention seeks to overcome the disadvantages of the prior art by: drilling a first bore 10 along a first predetermined path, the first bore having a length of at least 25 m; drilling a plurality of second bores 20 along respective second predetermined paths, each substantially parallel to the first predetermined path in order to define a substantially prism-shape region therebetween; and excavating material within the substantially prism-shape region to form a tunnel. In this way, data from drilling the first bore 10 and the plurality of second bores 20 can be recorded and used to inform operators as to the types of material through which they will be excavating. Thus, a more complete view of the underlying geology can be achieved before beginning excavations.

Abstract: A nanopore system provided herein includes first and second fluidic reservoirs in fluidic communication with a nanopore forming a fluidic path between the reservoirs. An enzyme clamp, provided in the first fluidic reservoir, abuts the nanopore and is reversibly bound to a sequential plurality of polymer subunits of a target polymer molecule in ionic solution. The clamp has an outer clamp diameter that is greater than the nanopore diameter. An electrical circuit includes an electrode in each of the reservoirs for applying a voltage bias across the nanopore. A pulse generator is connected in the electrical circuit to apply control pulses across the nanopore to step the clamp along sequential polymer subunits of the target polymer molecule. The system includes no fuel or source of fuel for the clamp. A controller is connected in the electrical circuit for controlling the collection of electrical indications of polymer subunits.

Abstract: In a method p for controlling translocation of a target polymer molecule through a nanopore, a clamp is reversibly bound to a sequential plurality of polymer subunits along the target polymer molecule length and the molecule and clamp are disposed in an ionic solution that is in fluidic communication with the nanopore. A constant translocation force is applied across the nanopore to induce travel of the target polymer molecule into the nanopore, until the clamp abuts the nanopore aperture and stops further travel of the target polymer molecule into the nanopore. Then a voltage control pulse is applied across the nanopore and/or a thermal control pulse is applied at the nanopore, with a pulse duration that steps the clamp along the target polymer molecule by no more than one polymer subunit in a direction opposite that of travel into the nanopore. No fuel is provided to the clamp.

Abstract: There is a desire to be able to generate electrical power from the tides without turbines posing an unacceptable hazard to sea traffic and/or life, and in particular without causing such sea traffic and/or life to alter their behaviour in response to the placement of turbines and/or other structures. According to the present invention, a tunnel (7) is provided at a height substantially between the low tide height and high tide height; a power take-off system (11) is configured to convert movement of water in the tunnel into usable energy. In this way, a tunnel inlet (5) may be placed at a location that does not interfere with shipping and/or the natural environment.

Abstract: There is a desire to be able to generate electrical power from the tides without turbines posing an unacceptable hazard to sea traffic and/or life, and in particular without causing such sea traffic and/or life to alter their behaviour in response to the placement of turbines and/or other structures. According to the present invention, a tunnel (7) is provided at a height substantially between the low tide height and high tide height; a power take-off system (11) is configured to convert movement of water in the tunnel into usable energy. In this way, a tunnel inlet (5) may be placed at a location that does not interfere with shipping and/or the natural environment.

Abstract: In a method p for controlling translocation of a target polymer molecule through a nanopore, a clamp is reversibly bound to a sequential plurality of polymer subunits along the target polymer molecule length and the molecule and clamp are disposed in an ionic solution that is in fluidic communication with the nanopore. A constant translocation force is applied across the nanopore to induce travel of the target polymer molecule into the nanopore, until the clamp abuts the nanopore aperture and stops further travel of the target polymer molecule into the nanopore. Then a voltage control pulse is applied across the nanopore and/or a thermal control pulse is applied at the nanopore, with a pulse duration that steps the clamp along the target polymer molecule by no more than one polymer subunit in a direction opposite that of travel into the nanopore. No fuel is provided to the clamp.

Abstract: The invention relates to a charging station (100) for charging mobile electronic devices (404), and an associated server (300), system (400), and method (500). The charging station (100) includes a plurality of lockable enclosures (120), each having an associated charging terminal (222), an input arrangement (124) operable to receive a mobile subscriber identifier, and a communication module (122) operable to communicate with a remote authorisation server (300).

Abstract: This invention relates to an apparatus and method for controlling electrical energy supply to one or more peripheral devices. The apparatus includes a first input operable to receive electrical energy from an electrical energy source and a battery operable to store the received electrical energy. The apparatus further includes at least one output operable to supply electrical energy to at least one peripheral device and an energy management controller operable to control the supply of electrical energy to the at least one peripheral device. The apparatus also includes a communications module operable to detect the purchase of prepaid airtime associated with the apparatus, with the energy management controller activating the peripheral device(s) for as long as there is sufficient airtime and deactivating the peripheral device(s) once the airtime has expired.

Abstract: A new and distinct cultivar of Cynara named ‘Z530’ that has improved productivity and year round harvest. ‘Z530’ produces one central and about fifteen lateral edible immature flower buds, and four side shoots during the first year.

Abstract: A new and distinct cultivar of Cynara named ‘X42’ that has improved productivity and year round harvest. ‘X42’ produces one central and about fifteen lateral edible immature flower buds, and four side shoots during the first year.

Abstract: A new and distinct cultivar of Cynara named ‘B13’ that has improved productivity and year round harvest. B13 produces one central and about fifteen lateral edible immature flower buds, and four side shoots during the first year.