Abstract: Compositions and methods are described for the delivery of therapeutic products (such as therapeutic proteins (for example, antibodies), therapeutic RNAs (for example, shRNAs, siRNAs, and miRNAs), and therapeutic aptamers) to the retina/vitreal humour in the eyes of human subjects to treat pathologies of the eye, involving, for example, recombinant viral vectors such as recombinant adeno-associated virus (rAAV) vectors.

Abstract: Reconfigurable antenna systems integrated with a metal case are provided herein. In certain embodiments, user equipment (UE) for a cellular network includes a metal case and an antenna system for transmitting and/or receiving wireless signals. The antenna system includes a tuning conductor formed in the metal case, a patch antenna element that is spaced apart from the tuning conductor, and a switch electrically connected in series between the tuning conductor and a ground voltage. The switch electrically connects the tuning conductor to the ground voltage in an on state and electrically disconnects the tuning conductor from the ground voltage in an off state.

Abstract: Beamforming communication systems with high linearity are provided. In certain embodiments, a method of beamforming includes generating a transmit signal using a baseband processor, providing digital pre-distortion to the transmit signal, generating a radio frequency input signal based on the transmit signal using a transceiver, processing the radio frequency input signal to generate a plurality of radio frequency output signals using a plurality of transmit signal paths of a front end system, providing analog pre-distortion to at least one of the plurality of transmit signal paths using the front end system, and radiating a transmit beam in response to receiving the plurality of radio frequency output signals using an antenna array.

Abstract: A catheter for use in a subject's vasculature includes a rotating and axially movable instrument. The instrument includes a rounded element at its distal end connected to a body having a spiral shape. The instrument is at least partially disposed in a lumen of the catheter and is configured for axial and rotational motion within the lumen between a proximal-most position and a distal-most position, where the body includes at least one edge configured to promote removal of a target substance from the body passageway upon contact with the target substance.

Abstract: Systems and methods are provided for displaying and interacting with multiple open views in a mobile environment. An example method can include displaying content for a first web page in a first pane in a maximized state on a mobile device, receiving a touch input on a navigation control associated with the first pane, and responsive to receiving the touch input, displaying a second web page in a second pane on the mobile device, the second pane being in a minimized state in a dock area. The dock area can overlay the first pane in the maximized state and the minimized state of the second pane can display a smaller version of the second web page than the second pane in a maximized state. In some examples the second web page updates content in parallel with the first web page.

Abstract: Embodiments of the present invention provide systems, methods, and computer storage media which retarget 2D screencast video tutorials into an active VR host application. VR-embedded widgets can render on top of a VR host application environment while the VR host application is active. Thus, VR-embedded widgets can provide various interactive tutorial interfaces directly inside the environment of the VR host application. For example, VR-embedded widgets can present external video content, related information, and corresponding interfaces directly in a VR painting environment, so a user can simultaneously access external video (e.g., screencast video tutorials) and a VR painting. Possible VR-embedded widgets include a VR-embedded video player overlay widget, a perspective thumbnail overlay widget (e.g., a user-view thumbnail overlay, an instructor-view thumbnail overlay, etc.), an awareness overlay widget, a tutorial steps overlay widget, and/or a controller overlay widget, among others.

Abstract: An insertion instrument is configured to eject at least one anchor body into respective target locations, and subsequently apply a predetermined tensile force at least one actuation member of the at least one anchor member so as to actuate the at least one anchor body from a first configuration to a second expanded configuration. The insertion instrument can include a tension assembly that applies the predetermined tensile force to the at least one actuation member. The predetermined tensile force can be defined by a distance of travel, a predetermined failure force of a fuse, or a combination of distance of travel and a predetermined failure force of a fuse.

Abstract: The invention relates to a pharmaceutical composition comprising a compound of formula I or a pharmaceutically acceptable salt thereof, and at least one pharmaceutical excipient selected from the group consisting of fillers, binders, disintegrants, glidants and lubricants, wherein the compound according to formula I is represented by:

Abstract: A method for increasing a speed and efficiency of a computer when performing machine learning using spiking neural networks. The method includes computer-implemented operations; that is, operations that are solely executed on a computer. The method includes receiving, in a spiking neural network, a plurality of input values upon which a machine learning algorithm is based. The method also includes correlating, for each input value, a corresponding response speed of a corresponding neuron to a corresponding equivalence relationship between the input value to a corresponding latency of the corresponding neuron. Neurons that trigger faster than other neurons represent close relationships between input values and neuron latencies. Latencies of the neurons represent data points used in performing the machine learning. A plurality of equivalence relationships are formed as a result of correlating. The method includes performing the machine learning using the plurality of equivalence relationships.

Abstract: Techniques for responsive video canvas generation are described to impart three-dimensional effects based on scene geometry to two-dimensional digital objects in a two-dimensional design environment. A responsive video canvas, for instance, is generated from input data including a digital video and scene data. The scene data describes a three-dimensional representation of an environment and includes a plurality of planes. A visual transform is generated and associated with each plane to enable digital objects to interact with the underlying scene geometry. In the responsive video canvas, an edit positioning a two-dimensional digital object with respect to a particular plane of the responsive video canvas is received. A visual transform associated with the particular plane is applied to the digital object and is operable to align the digital object to the depth and orientation of the particular plane. Accordingly, the digital object includes visual features based on the three-dimensional representation.

Abstract: A novel maize variety designated X00R819 and seed, plants and plant parts thereof are produced by crossing inbred maize varieties. Methods for producing a maize plant by crossing hybrid maize variety X00R819 with another maize plant are disclosed. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X00R819 through backcrossing or genetic transformation, and to the maize seed, plant and plant part produced thereby are described. Maize variety X00R819, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X00R819 are provided. Methods for producing maize varieties derived from maize variety X00R819 and methods of using maize variety X00R819 are disclosed.

Abstract: Reconfigurable antenna systems integrated with a metal case are provided herein. In certain embodiments, user equipment (UE) for a cellular network includes a metal case and an antenna system for transmitting and/or receiving wireless signals. The antenna system includes a tuning conductor formed in the metal case, a patch antenna element that is spaced apart from the tuning conductor, and a switch electrically connected in series between the tuning conductor and a ground voltage. The switch electrically connects the tuning conductor to the ground voltage in an on state and electrically disconnects the tuning conductor from the ground voltage in an off state.

Abstract: An aqueous cell culture medium composition includes an aqueous cell culture solution configured to support the culture of mammalian cells. The composition further includes a synthetic polymer conjugated to a polypeptide dissolved in the aqueous cell culture solution. The synthetic polymer conjugated to a polypeptide is configured to attach to the surface of a cell culture article under cell culture conditions. Incubation of the aqueous cell culture medium composition on a cell culture surface under cell culture conditions results is attachment to the surface of the synthetic polymer conjugated to the polypeptide.

Abstract: A novel maize variety designated PH42SG and seed, plants and plant parts thereof are provided. Methods for producing a maize plant comprise crossing maize variety PH42SG with another maize plant are provided. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH42SG through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby are provided. Hybrid maize seed, plants or plant parts are produced by crossing the variety PH42SG or a locus conversion of PH42SG with another maize variety.

Abstract: A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: W is O, N—H, N—(C1-C10 alkyl) or S; each X is independently CH or N; R1 is a 5 to 7-membered saturated or unsaturated, optionally substituted heterocycle containing at least 1 heteroatom selected from N or O; R2 is LY; each L is a direct bond, C1-C10 alkylene, C2-C10 alkenylene or C2-C10 alkynylene; Y is an optionally substituted fused, bridged or spirocyclic non-aromatic 5-12 membered heterocycle containing up to 4 heteroatoms selected from N or O; and each R3 is independently H, C1-C10 alkyl, halogen, fluoro C1-C10 alkyl, O—C1-C10 alkyl, NH—C1-C10 alkyl, S—C1-C10 alkyl, O-fluoro C1-C10 alkyl, NH-acyl, NH—C(O)—NH—C1-C10 alkyl, C(O)—NH—C1-C10 alkyl, aryl or heteroaryl, are useful as inhibitors of the class IA phosphoinositide 3-kinase enzyme, PI3K-p110?, and therefore have potential utility in the therapy of cancer, immune and inflammatory diseases.

Abstract: A novel maize variety designated X95R014 and seed, plants and plant parts thereof are produced by crossing inbred maize varieties. Methods for producing a maize plant by crossing hybrid maize variety X95R014 with another maize plant are disclosed. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X95R014 through backcrossing or genetic transformation, and to the maize seed, plant and plant part produced thereby are described. Maize variety X95R014, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X95R014 are provided. Methods for producing maize varieties derived from maize variety X95R014 and methods of using maize variety X95R014 are disclosed.

Abstract: A transportable enclosure can include a housing, a power source, a container, an evaporator, a condenser, a compressor, and a controller. The container can be configured to receive a temperature sensitive item therein. The evaporator can be disposed at least partially around the container. The condenser can be positioned near a wall of the housing and can be configured to reject heat from the evaporator to an ambient environment through the wall of the housing.

Abstract: Crossbar switches for coarse phase shifting are disclosed. In certain embodiments, a mobile device includes an antenna array including a plurality of antennas. The mobile device further includes a front end system coupled to the antenna array and including a plurality of signal conditioning circuits each including a phase shifter. The plurality of signal conditioning circuits each provide phase shifting to a respective one of a plurality of radio frequency signals based on a fine control signal. The front end system further includes a crossbar switch coupled to the plurality of signal conditioning circuits and configured to provide phase shifting to the plurality of radio frequency signals based on a coarse control signal.

Abstract: Various exemplary embodiments include a valuation system to measure sponsorship exposure in social media, including the ability to use multiple valuation methods, such as CPV, CPM, and CPE, integrated into the valuation system, in a real-time manner, while aggregating the most up-to-date data. It may categorize the social media by media type, image, video or text, and may run different valuation strategies based on the media type. It may adapt a valuation strategy based on the source platform of the publication, detect the sponsorship exposures and inputs into the valuation method, as one or more factors to the valuations system, in the real-time matter. Additionally, granular valuation may be supported, given the output from the AI-driven system, on brand, asset, scene, and media exposure types. It also supports valuation on a real-time ad rate, a device factor, customization based on user configurations, e.g., discounted factor, and/or supports live stream.

Abstract: Systems and methods are provided for displaying and interacting with multiple open views in a mobile environment. An example method can include displaying a current pane in a maximized state and at least a first pane in a minimized state in a dock area. The current pane is a top of a stack list and displays content associated with a first location and the first pane is in a dock list and displays content associated with a second location. The minimized state for a pane is a scaled down version of the maximized state for the pane, the scale applying to the content for the pane and a size of the pane. The method also includes receiving a drag input on the first pane in the dock area and scaling the size of the first pane according to proximity to the dock area.