Abstract: Pharmaceutical compositions and methods of their use are provided for reducing inflammation in a subject, blocking leukocyte recruitment, inhibiting tumor metastasis, treating sepsis and preventing/reducing acute kidney injury.

Abstract: The present invention relates to peptidomimetics having a stable, internally constrained protein secondary structure, where the peptidomimetics contain a hydrogen bond surrogate in the internal constraint, and at least one beta amino acid. Methods for promoting cell death using peptidomimetics that inhibit p53/hDM2 are also disclosed.

Abstract: An interconnection structure for coupling conductive layers of a circuit board includes a pin configured to be press-fitted in an aperture traversing the circuit board, to electrically couple the conductive traces. The pin may be placed in a predrilled aperture, or driven into the circuit board, forming the aperture thereby. The pin may also be configured as a punch, removing a plug of material as it is driven therethrough. The pin may comprise a capacitive or resistive region configured to capacitively or resistively couple the first and second traces. The pin may be configured such that capacitive or resistive values are selectable according to a depth to which the pin is positioned in the aperture. The pin may serve as an offset post for mounting the circuit board to a chassis. In such a case, the pin may be provided with a longitudinal aperture configured to receive a threaded screw.

Abstract: The electrical contacts, such as ball grid array (BGA) solder balls, of an integrated circuit (IC) are coupled to printed circuit board (PCB) bonding pads that include vias. According to an embodiment of an electronic assembly, the vias are formed off-center, so as to inhibit bridging between adjacent solder balls during a solder reflow operation by minimizing the effect of solder ball ballooning resulting from outgassing of a thermally expansive substance, such as a volatile organic compound (VOC) from the via channels. The bonding pads are separated into two groups, each having vias offset in a different direction, so that asymmetric surface tension forces in the molten solder during a solder reflow operation do not cause the IC to slide to one side. A substrate, an electronic assembly, an electronic system, and fabrication methods are also described.

Abstract: In an exemplary embodiment, a customer, an automobile dealership, a participating financial institution, and a credit bureau may be electronically connected in a system that preferably uses the internet in order to develop and process a legal document comprising a credit application. The system thereby eliminates a paper-based process of credit approval, providing an efficient interaction between businesses and their customer.

Abstract: A wake up server permits both parties (the receiver and the responder) to be connected to the Internet only when a request or response is to be delivered. The wake up server consists of two parts; a server, which contains the telephone numbers of all machines (application partners) that dial to connect to the Internet, and on each application partner, a process monitor that monitors the telephone line and detects when a ring occurs. When an application partner is unable to deliver a request or response to another application partner, a request is sent to the wake up server to activate the target application partner. The wake up server dials the telephone number of the requested application partner and waits for ringing to occur. The wake up server then disconnects (i.e., hangs up the telephone line). The wake up monitor detects the ring and immediately dials to connect to the Internet. When the original application partner tries to send the response or request again, the process will now be successful.

Abstract: Transactions are conducted on the Internet, by telephone or directly with anonymity and privacy. A customer's shipping address is encoded by a multi-digit identifier which is stored in the database of a trusted third party, preferably the shipping company. A user of the system need only identify themselves to a vendor by this multi-digit identifier which prints the identifier in machine readable form on a package delivered to the shipper.